ROLE OF CERTAIN DRUGS IN CARDIOTOXICITY INDUCTION FOR THE EXPERIMENTAL PURPOSE
Cardiovascular diseases are caused by disorders of the heart and blood vessels and it remains the principal cause of death in both developed and developing countries, accounting for roughly 20%. Cardiotoxicity renders the heart unable to efficiently pump blood throughout the body. Oxidative stress resulting from the higher production of free radicals that plays a major role in cardiovascular disease. Cardiotoxicity is described as the harmful effect on the heart caused by various drugs. Anticancer drugs, antipsychotic drugs, methamphetamine, isoproterenol, minoxidil, cyclosporine A, azithromycin, tilmicosin etc., can able to produce cardiotoxicity by various mechanisms. In this context, we have made an attempt to explore the therapeutic drugs induced cardiotoxicity in experimental animal models with their dose and mechanism.
2. Upaganlawar A, Patel V, Balaraman R. Tomato lycopene attenuates myocardial infarction induced by Isoproterenol electrocardiographic, biochemical and anti-apoptotic study. Asian Pac J Trop Biomed 2012;2:345-51.
3. Ghosh A, Bhagat M, Das M, Kumar S, Goswami BR, Pal S. Prevalence of cardiovascular disease risk factors in people of Asian Indian origin: age and sex variation. J Cardiovasc Dis 2010;1:81-5.
4. Roy JA, Prince MSP. Preventive effects of p-coumaric acid on cardiac hypertrophy and alterations in electrocardiogram, lipids, and lipoproteins in experimentally induced myocardial infracted rats. Food Chem Toxicol 2013;60:348-54.
5. De Bono DP, Boon NA. Diseases of the cardiovascular system. In: Edwards CRW, Boucheir IAS. editors. Davidson's principles of practice and medicine. Hong Kong: Churchill Livingstone; 1992. p. 249-340.
6. Rajadurai M, Stanely Mainzen Prince P. Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in wistar rats. J Biochem Mol Toxicol 2006;20:191-7.
7. Radhika S, Smila KH, Muthezhilan R. Cardioprotective activity of Hybanthus enneaspermus (Linn.) on isoproterenol-induced rats. Indian J Fundam Appl Life Sci 2011;1:90-7.
8. Albini A, PenÃ©is G, Donatelli F, Cammarota R, Flora SD, Noonan DM. Cardiotoxicity of anticancer drugs: The need for cardio-oncology and cardiooncological prevention. J Nat Cancer Inst 2010;102:14-25.
9. Shalini K, Pisupati SRS, A Priya Darshini G, Vijay RC, Uma Maheswara RV. Cardiotoxicity and use of herbal drugs-a review. Asian J Pharm Res Dev 2014;2:1-9.
10. Miranda CJ, Makui H, Soares RJ. Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. Blood 2003;102:2574-80.
11. Simunek T, Sterba M, Popelova O, Adamcova M, Hrdina R, Gersi V. Anthracycline-induced cardiotoxicity: an overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacological Reports 2009;61:154-71.
12. Yeh ET. Cardiotoxicity induced by chemotherapy and antibody therapy. Annu Rev Med 2006;112:1853-87.
13. Grenier MA, Lipshultz SE. Epidemiology of anthracycline cardiotoxicity in children and adults. Semin Oncol 1998; 25:72-85.
14. Booser DJ, Hortobagyi GN. Anthracycline antibiotics in cancer therapy. Focus on drug resistance. Drugs 1994;47:223-58.
15. Mobaraki M, Faraji A, Zare M, Dolati P, Ataei M, Dehghan Manshadi HR. Molecular mechanisms of cardiotoxicity: a review on the major side-effects of doxorubicin. Indian J Pharm Sci 2017;79:335-44.
16. Aysel G, Ozlem Y, Meryem C, Feriha E, Neslihan B, Cem C. Melatonin protects against epirubicin-induced cardiotoxicity. Acta Histochemica 2007;109:52-60.
17. Panis C, Herrera ACSA, Victorino VJ. Oxidative stress and haematological profiles of advanced breast cancer patients subjected to paclitaxel or doxorubicin chemotherapy. Breast Cancer Res Treatment 2012;133:89-97.
18. Doroshow JH, Locker GY, Myers CE. Enzymatic defences of the mouse heart against reactive oxygen metabolites. J Clin Invest 1980;65:128-35.
19. Minotti G, Mancusco C, Frustaci A, Mordente A, Santini SA, Calafiore AM, et al. Paradoxical inhibition of cardiac lipid peroxidation in cancer patients treated with doxorubicin. J Clin Invest 1996;98:650-61.
20. Kirsten S, Dick R, Renee van den B, Henk Jan G. Cardiotoxicity of Cytotoxic drugs. Cancer Treat Rev 2004;30:181-91.
21. Huber SA. Doxorubicin-induced alterations in cultured myocardial cells stimulate cytolytic T lymphocyte responses. Am J Pathol 1990;137:449-56.
22. Frits A, de Wolf. Binding of doxorubicin to cardiolipin as compared to other anionic phospholipids-an evaluation of electrostatic effects. Biosci Rep 1991;11:275-84.
23. Shanmugarajan TS, Arunsundar M, Somasundaram I, Krishnakumar E, Sivaraman D, Ravichandiran V. Cardio-protective effect of Ficus hispida Linn. on cyclophosphamide provoked oxidative myocardial injury in a rat model. Int J Pharmacol 2008;4:78-87.
24. Hochster H, Wasserheit C, Speyer J. Cardiotoxicity and cardioprotection during chemotherapy. Curr Opin Oncol 1995;7:304-9.
25. Kandylis K, Vassilomanolakis M, Tsoussis S, Efremidis AP. Ifosfamide cardiotoxicity in humans. Cancer Chemother Pharmacol 1989;24:395-6.
26. Abdurrauf Y, Ahmet A, Ali OC, Mesut A. Ellagic acid prevents cisplatin-induced oxidative stress in liver and heart tissue of rats. Basic Clin Pharmacol Toxicol 2007;101:345-9.
27. Icli F, Karaoguz H, Dincol D, Dermirkazik A, Gunel N, Karaoguz R, et al. Severe vascular toxicity associated with cisplatin-based chemotherapy. Cancer 1993;15:587-93.
28. Doll DC, List AF, Greco FA, Hainsworth JD, Hande KR, Johnson DH. Acute vascular ischemic events after cisplatin-based combination chemotherapy for germ-cell tumours of the testis. Ann Intern Med 1986;105:48-51.
29. Gerl A, Clemm C, Wilmanns W. Acute cerebrovascular event after cisplatin-based chemotherapy for testicular cancer. Lancet 1991;338:385-6.
30. Togna GI, Togna AR, Franconi M, Caprino L. Cisplatin triggers platelet activation. Throm Res 2000;99:503-9.
31. Zhang F, Suarez G, Sha J, Sierra JC, Peterson JW, Chopra AK. Phospholipase A2-activating protein (PLAA) enhances cisplatin-induced apoptosis in HeLa cells. Cellular Signalling 2009;21:1085-99.
32. Shoemaker LK, Arora U, Rocha Lima CM. 5-fluorouracil-induced coronary vasospasm. Cancer Controlled 2004;11:46-9.
33. Grem JL. 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development. Invest New Drugs 2000;18:299-313.
34. Arellano M, Malet-Martino M, Martino R, Gires P. The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate. Br J Cancer 1998;77:79-86.
35. Becker K, Erckenbrecht JF, Haussinger D, Frieling T. Cardiotoxicity of the antiproliferative compound fluorouracil. Drugs 1999;57:475-84.
36. Alter P, Herzum M, Soufi M, Schaefer JR, Maisch B. Cardiotoxicity of 5-fluorouracil. Cardiovasc Haematol Agents Med Chem 2006;4:1-5.
37. Ensley JF, Patel B, Kloner R, Kish JA, Wynne J, Al-Sarraf M. The clinical syndrome of 5-fluorouracil cardiotoxicity. Invest. New Drugs 1989;7:101-9.
38. Fadi T Khasawneh, Gollapudi S Shankar. Minimizing cardiovascular adverse effects of atypical antipsychotic drugs in patients with schizophrenia. Cardiology Research and Practice; 2014.
39. Abdel Wahab BA, Metwally E. Clozapine-induced cardiotoxicity in rats: Involvement of tumour necrosis factor alpha, NF-and caspase-3. Toxicol Reports 2014;1:1213-23.
40. Belhania D, Frassatib D, Megard R, Tsibiribia P, Bui-Xuana B, Tabib A, et al. Cardiac lesions induced by neuroleptic drugs in the rabbit. Exp Toxicol Pathol 2006;57:207-12.
41. Masafumi T, Toshiko O, Hironobu K, Yoko W, Kotaro S, Masayuki N, et al. Cardiotoxicity of methamphetamine under stress conditions: comparison of single dose and long-term use. Mol Med 2013;7:1786-90.
42. Volkow ND, Joanna SF, Gene-Jack W, Elena S, Frank T, Peter KT, et al. Distribution and pharmacokinetics of methamphetamine in the human body: clinical implications. PLoS One 2010;5:e15269.
43. Kaye S, McKetin R. Cardiotoxicity associated with methamphetamine use and signs of cardiovascular pathology among methamphetamine users. NDARC; 2005.
44. Amal D, Fedia BM, Kais M, Mouna T, Salwa J, Rawdha BA, et al. Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol-induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme. Exp Toxicol Pathol 2017;69:656-65.
45. Menaka CT, Ravirajsinh NJ, Ansarullah, Sanjay SK, Jigar DS, Dipak KP, et al. Cardioprotective effect of sida rhomboidea. Roxb extract against isoproterenol induced myocardial necrosis in rats. Exp Toxicol Pathol 2011;63:351-6.
46. Goyal SN, Arora S, Sharma AK, Joshi S, Ray R, Bhatia J, et al. Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastructural alterations in isoproterenol-induced cardiotoxicity in rats. Phytomedicine 2010;17:227â€“32.
47. Priya S, Dharamveer P. Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol-induced myocardial infarction in Wistar Albino rats. J Acute Disease 2014;3:228-34.
48. Eugene HH, Victor JF, Robert SKY, Tibor B. A comparative study of minoxidil-induced myocardial lesions in beagle dogs and miniature swine. Toxicol Pathol 1989;17:182-92.
49. Uz E, Uz B, Selcoki Y, Bayrak R, Kaya A, Turgut HF, et al. Cardioprotective effects of Nigella sativa oil on cyclosporine a-induced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol 2008;103:574-80.
50. El-Shitany NA, El-Desoky K. Protective effects of carvedilol and vitamin C against azithromycin-induced cardiotoxicity in rats via decreasing ROS, IL1-ð›½, and TNF-ð›¼ production and inhibiting NF-ðœ…B and caspase-3 expression. Oxidative Medicine and Cellular Longevity; 2016.
51. Ozlem A, Sinem I, Hakan A, Dilek B. Evaluation of azithromycin-induced cardiotoxicity in rats. Int J Clin Exp Med 2015;8:3681-90.
52. Abdelaziz EI, Mohamed MAD. Modulating effects of spirulina platensis against tilmicosin-induced cardiotoxicity in mice. Cell J 2015;17:137-44.
53. Samah SO, Amira ED. Impact of diclofenac sodium on tilmicosin-induced acute cardiotoxicity in rats (Tilmicosin and Diclofenac Cardiotoxicity). Cardiovasc Toxicol 2017;18:63-75.
54. Kursad Y, Asim K, Mahmut K. Effects of different doses of tilmicosin on some biochemical parameters and antioxidant status in serum and cardiac tissues in mice. Bull Vet Inst Pulawy 2006;50:605-8.
55. Elberry AA, Abdel-Naim AB, Abdel-Sattar EA, Nagy AA, Hisham AM, Mohamadin FAM, et al. Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. Food Chem Toxicol 2010;48:1178-84.
56. Kaithwas G, Dubey K, Pillai KK. Effect of Aloe vera gel on doxorubicin-induced myocardial oxidative stress and calcium overload in albino rats. Indian J Exp Bio 2011;48:260-8.
57. Vijay T, Dhana RMS, Sarumathy K, Palani S, Sakthivel K. Cardioprotective, antioxidant activities and phytochemical analysis by GC-MS of Gmelina arborea (GA) in doxorubicin-induced myocardial necrosis in Albino rats. J Appl Pharm Sci 2011;1:198-204.
58. Paramasivam R, Dominic S, Chinthamony A, Kanniappan GV. Cardioprotective effect of aqueous, ethanol and aqueous ethanol extract of Aerva lanata (Linn.) against doxorubicin-induced cardiomyopathy in rats. Asian Pacific J Trop Biomed 2012;2:S212-S218.
59. Bertinchant JP, Polge A, Jaun, Oliva L, Giuliani I, Marty-Double C, et al. Evaluation of cardiac troponin I and T levels as markers of myocardial damage in doxorubicin-induced cardiomyopathy rats, and their relationship with echocardiographic and histological findings. Clin Chim Acta 2003;329:39-51.
60. Osman AMM, Marwa MN, Abou-Bakr AA, Omimah AN, Mohamed TK. Effect of methimazole treatment on doxorubicin-induced cardiotoxicity in mice. Food Chem Toxicol 2009;47:2425-30.
61. Khan M, Shobha JC, Mohan IK, Naidu MU, Sundaram C, Singh S, et al. Protective effect of Spirulina against doxorubicin-induced cardiotoxicity. Phytother Res 2005;19:1030-7.
62. Xin YF, Wan L, Peng JL, Guo C. Alleviation of the acute doxorubicin-induced cardiotoxicity by Lycium barbarum polysaccharides through the suppression of oxidative stress. Food Chem Toxicol 2011;49:259-64.
63. Sakthivel K, Palani S, Santhosh KR, Devi K, Senthil KB. Phytoconstituents analysis by gc-ms, the cardioprotective and antioxidant activity of Buchanania axillaris against doxorubicin-induced cardiotoxicity in albino rats. Int J Pharma Studies Res 2010;1:34-48.
64. Xin YF, Zhou GL, Deng ZY, Chen YX, Wu YG, Xu PS, et al. Protective effect of Lycium barbarum on doxorubicin-induced cardiotoxicity. Phytother Res 2007;21:1020-4.
65. Eman TM, Ghada MS. Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil. Beniâ€“Suef University J Basic Appl Sci 2016;5:208-21.
66. Alaa RK, Intesar TN. Possible cardio-protective effects of telmisartan against 5-fluorouracil-induced cardiotoxicity in wister rats. Int J Pharm Pharm Sci 2014;6:397-400.
67. Abdel-Wahab BA, Metwally EA, El-khawanki MM. Does clozapine induce myocarditis, myocardial oxidative stress and DNA damage in rats? Egyptian J Forensic Sci 2014;4:75-82.
68. Yi SH, Ren L, Yang TT, Liu L, Wang H, Liu Q. Myocardial lesions after long-term administration of methamphetamine in rats. Chin Med Sci J 2008;23:239-43.
69. Motahareh K, Fatemeh S, Daniel J. Protective effects of edaravone against methamphetamine-induced cardiotoxicity. Braz Arch Biol Technol 2016;59:e16160093.
70. Rafeek HB, David HP. An in vivo and in vitro study on the protective effects of N-acetylcysteine on mitochondrial dysfunction in isoproterenol-treated myocardial infarcted rats. Exp Toxicol Pathol 2013;65:7-14.
71. Ramalingam S, Pon Velayutham, Anandh Babu, Chennam SS. Aspartate and glutamate prevents isoproterenol-induced cardiac toxicity by alleviating oxidative stress in rats. Exp Toxicol Pathol 2011;63:137-42.
72. Kapil S, Salma M, Nanda G, Rajiv KM, Sameer NG, Jagriti B, et al. Kampeferol protects against oxidative stress and apoptotic damage in an experimental model of isoproterenol-induced cardiac toxicity in rats. Phytomedicine 2016;23:1401-8.
73. Sunmonu TO, Afolayan AJ. Protective effect of Artemisia afra Jacq. on isoproterenol-induced myocardial injury in Wistar rats. Food Chem Toxicol 2010;48:1969-72.
74. Tarak NK, Raju P, Santosh K, Madhusudana K, Sachin BA, Srigiridhar K, et al. Garlic provides protection to mice heart against isoproterenol-induced oxidative damage: the role of nitric oxide. Nitric Oxide 2012;27:9-17.
75. Wang S, Tian S, Yang F, Yang HG, Yang XY, Du GH. Cardioprotective effect of salvianolic acid an on isoproterenol-induced myocardial infarction in rats. Eur J Pharmacol 2009;615:125-32.
76. Tarak NK, Amit KD, Uday KP, Sanjay KB. Diallyl disulfide ameliorates isoproterenol-induced cardiac hypertrophy activating mitochondrial biogenesis via an eNOS-Nrf2-Tfam pathway in rats. Biochem Biophys Reports 2016;5:77-88.
77. Eugene HH, Jun Zhang, Douglas P, Chadwicka, Victor JF. Age dependence of the cardiac lesions induced by minoxidil in the rat. Toxicology 1996;110:71-83.
78. Atli O, Ilgin S, Altuntas H, Burukoglu D. Evaluation of azithromycin-induced cardiotoxicity in rats. Int J Clin Exp Med 2015;8:3681-90.
79. Kart A, Yapar K, Karapehlivan M, Citil M. The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice. J Vet Med Physiol Pathol Clin Med 2007;54:144-6.
80. Kristiana N, Fadlina CS. The effect of secang extract (Caesalpinia sappan linn) on the weight and histology appearance of white male ratsâ€™ hearts induced by isoproterenol. Int J Appl Pharm 2017;9 Suppl 1:59-61.