Veena Sharma, Urmila Chaudhary


Achyranthes aspera Linn. (Amaranthaceae family) a medicinal plant is found throughout India as an annual herb. In this plant many antioxidants like alkaloids, terpenoids, saponins etc. of various pharmacological properties are present. Many chemical constituents have also been isolated from this plant by various techniques. All chemical constituents and pharmacological properties are responsible for the treatment of various human disorders. In the present review, complete updated information about Achyranthes aspera pharmacological, phytochemical and ethnobotanical uses is provided. The above information about A. aspera may be helpful to researchers in further research.

Keywords: Achyranthes aspera, Anticancer, Antioxidants, Medicinal plants.

| PDF | HTML |


Holm G, Herbst V, Teil B. Brogenkunde. IN: Plant Med 1998; 67:263-9.

Sivasankari K, Janaky S, Sekar T. Evaluation of photochemical in select medicinal plants of the caesalpinia species. Indian J Sci Technol 2010; 3:0974-6846.

Edeoga HO, Okwu DE, Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol 2005; 4(7):685-8.

Korwar PG, Beknal AK, Patil BS, Halkai MA, Kulkarni U, Hariprasanna RC, et al. A study on phytochemical investigation of Drynariaquercia Linn rhizome. Int J Pharm Sci Res 2010; 1(12):148-58.

Sutar N, Garai R, Sharma UM, Goyal P, Yadav G. Pharmacognostic studies of the Achyranthes aspera leaves. Int J Compr Pharm 2011; 5(10):0976-8157.

Dey A. Achyranthes aspera L: phytochemical and pharmacological aspects. Int J Pharm Sci Rev Res 2011; 9(2):013.

Dwivedi S, Dubey R, Mehta K. Achyranthes aspera Linn. (Chirchira): a magic herb in folk medicine. Ethno Botanical Leaves lets 2008; 12:670-6.

Neeta SR, Jyoti B, Singh A, Kaur P. Antibacterial potential of Achyranthes aspera Linn. procured from Himachal Pradesh, Punjab and Haryana, India. Res J Chem Sci 2011; 1(8):80-2.


Srivastav S, Singh P, Mishra G, Jha KK, Khosa RL. Achyranthes aspera-an important medicinal plant: a review. J Nat Prod Plant Resour 2011; 1(1):1-14.

Fern K. Achyranthes aspera. Plants for a Future; 1996.

Krishnaveni A1, Thaakur SR. Pharmacognostical and preliminaryphytochemical studies of Achyranthes aspera Linn. Anc Sci Life 2006; 26(1-2):1-5.

Jadav HR, Galib R, Prajapati PK, Harisha CR. Pharmacognostical study on flowers and fruits of Apamarga (Achyranthes aspera Linn.). Int J Green Pharm 2013; 7:136-9.

Bir SS, Sidhu. Cytological observations in weed flora of orchards of Patiala district, Punjab. Recent Res Pl Sci 1979; 7:261-71.

Morton JK. Chromosome numbers and poly-ploidy in the flora of the cameroon mountain. Opera Bot 1993; 121:159-72.

De Lange PJ, Scofield RP, Greene T. Achyranthes aspera (Amaranthaceae), a new indigenous addition to the flora of the Kermadec Islands group. New Zealand J Bot 2004; 42:167-73.

Bir SS, Sidhu M. Cyto-palynological studies on weed flora of cultivable lands of Patiala district (Punjab). J Palynol 1980; 16:85-105.

Kumar A. Polyploidy in Achyranthes aspera and Chrysanthemum leucanthemum. Acta Bot Indica 1982; 10:141-2.

Sharma V, Chaudhary U, Singh R, Agarwal A. Achyranthes aspera: phytochemical estimation. Am J Pharmtech Res 2013a; 3(2):242-51.

Sharma V, Agarwal A, Chaudhary U, Singh M. Phytochemical Investigation of various extracts of leaves and stems of achyranthes aspera linn. Int J Pharm Pharm Sci 2013b; 5(1):317-20.

Banerji A, Chintalwar GJ, Joshi NK. Isolation of ecdysterone from Indian plants. Phytochem 1971; 10:2225-6.

Laddha KS, Ghosh D. Isolation of 20-Hydroxyecdysone from Indian medicinal plant achyranthes aspera and development of simple HPLC analysis. Nat Prod 2005; 1(1-2):10-3.

Kapoor VK, Singh H. Isolation of betaine from Achyranthes aspera Linn. Indian J Chem 1966; 4(10):461-3.

Kunert O, Haslinger E, Martin, Schmid, Reiner J, Bucar F, et al. Three saponins steroids and a flavanol glycoside from Achyranthes aspera. Monatsh Chem 2000; 131(2):195-204.

Michl G, Abebe D, Bucar F, Debella A, Kunert O, Schmid MG, et al. New triterpenoid saponins from Achyranthes aspera Linn. Helv Chim Acta 2000; 83(2):359-63.

Batta AK, Rangaswami S. Crystalline chemical components of some vegetable drugs. Phytochem 1973; 12:214-6.

Misra TG, Singh RS, Pandey HS, Prasad C. An aliphatic dihydroxyketone from Achyranthes aspera. Phytochem 1991; 30(6):2076-8.

Rastogi RP, Mehrotra BN. Compendium of indian medicinal plants. Central Drug Research Institute, Lucknow and National institute of science communication and information resources, New Delhi; 2004; 5(11):7-8.

Misra TG, Singh RS, Pandey HS, Prasad C, Singh BP. Two long chain compounds from Achyranthes aspera. Phytochem 1993; 33(1):221-3.

Gariballa Y, Iskander GM, Daw El Beit A. Investigation of the alkaloid components in the Sudan Flora III. Fitoterapia 1983; 54:269-72.

Misra TN, Singh RS, Pandey HS, Prasad C, Singh S. Isolation and characterization of two new compounds from Achyranthes aspera Linn. Indian J Chem 1996; 35B(6):637-9.

Ali M. Chemical investigation of Achyranthes aspera Linn. Oriental J Chem 1993; 9(1):84-5.

Rameshwar RD. Essential oil constituents of Achyranthes aspera leaves. Indian Perfum 2007; 51(1):33-4.

Khastgir HN, Gupta PS. The sapogenin from seeds of Achyranthes aspera Linn. J Indian Chem Soc 1985; 35:693-4.

Hariharan V, Rangaswami S. Structure of saponines A and B from the seeds of Achyranthes aspera. Phytochem 1970; 9:409-14.

Chauhan AS, Rawat GS, Singh CP. Phytochemical study of Achyranthes aspera Linn. Asian J Chem 2002; 14(2):1059-61.

Daulatabad CD, Ankalgi RF. Minor seed oils II: fatty acid composition of some seed oils. Fette Seifen Anstrichm 1985; 87(5):196-7.

Rameshwar RD, Akito N. Three oleanolic acid glycosides from the seeds of a Achyranthes aspera. Nat Prod Commun 2007; 2(7):727-30.

Banerji A, Chadha MS. Insect moulting hormone from Achyranthes aspera. Phytochem 1970; 9:1671.

Ikan R, Ravid U, Trosset D, Shulman E. Ecdysterone: an insect moulting hormone from Achyranthes aspera (Amaranthaceae). Cell Mol Life Sci 1971; 27(5):504-5.

Sharma SK, Vasudeva N, Ali M. A new aliphatic acid from Achyranthes aspera Linn. Roots Indian J Chem 2009; 48B:1164-9.

Seshadri V, Batta AK, Rangaswami S. Structure of two new saponins from Achyranthes aspera. Indian J Chem Sect B Org Chem Incl Med Chem 1981; 20B(9):773-5.

Shekhawat NS, Ramawat KG, Arya HC. Carbohydrate, Proteins, Phenols and enzymes (PPO,PRO & IAA oxidase) in gall and normal tissues of Achyranthes aspera L. Curr Sci 1978; 47(20):780-1.

Dwivedi S, Dubey R, Mehta K. Achyranthes aspera Linn. (Chirchira): a magic herb in folk medicine. Ethnobot Leaflets 2008; 12:670-6.

Barua CC, Begum SA, Talukdar A, Pathak DC, Sarma DK, Bora R. Wound healing activity of methanolic extract of leaves of Achyranthes aspera Linn. using in vivo and in vitro model-a preliminary study. Indian J Anim Sci 2010; 80(10):969-72.

Sharma V, Singh R, Chaudhary U. Curative efficacy of Achyranthes aspera against various pathogenic microbial strains. Int J Drug Dev Res 2013c; 5(1):392-401.

Sharma V, Singh R, Paliwal R, Chaudhary U, Agarwal A. MIC values of inflorescence and leaves extracts of Achyranthes aspera against usual pathogenic bacterial strains. Asian J Pharm Clin Res 2013d; 6(1):185-7.

Goyal BR, Mahajan SG, Mali RG, Goyal RK, Mehta AA. Beneficial effect of achyranthes apsera linn. in toluene-di-isocyanate induced occupational asthma in rats. Global J Pharmacol 2007; 1(1):06-12.

Sutar NG, Sutar UN, Sharma YP, Shaikh IK, Kshirsagar SS. Phytochemical investigation and pharmacological screening of leaves of Achyranthes aspera L. as analgesic and antipyretic. Biosci Biotechnol Res Asia 2008; 5(2):841-4.

Mehta FA, Patel BG, Pandya SS, Ahir KB, Patel SB. Antinociceptive and anti-inflammatory activity of Achyranthes aspera L. extracts. Pharmacologyonline 2009; 3:978-85.

Kumar H, Singh D, Kushwaha SKS, Gupta AK. Comparison of leaf and root extracts Achyranthes aspera for its analgesic activity. Der Pharm Lett 2009; 1(2):193-8.

Bhosale U, Yegnanarayan R, Prachi P, Zambare M, Somani RS. Antinociceptive evaluation of an ethanol extract of Achyranthes aspera (agadha) in animal models of Nociception. Int J Phytomed 2010; 2:440-5.

Alam MA, Slahin N, Uddin R, Hasan SMR, Akter R, Kamaluddin, et al. Analgesic and neuropharmacological investigations of the aerial part of achyranthes aspera linn. S J Pharm Sci 2008; 1(1-2):44-50.

Bharathi NM, Sravanthi V, Sujeeth S, Kalpana K, Santhoshi P, Pavani M, et al. In-vitro anthelmintic activity of methanolic and aqueous extracts of achyranthes aspera Linn. (Amaranthaceae) Stems. Int J Pharm Sci 2013; 3(2):181-4.

Umamaheswari M, Sundaram D, Thirumalaiswamy S, Varadharajan S, Jagannath P, Arumugam M. Anticataract and antioxidant activities of Achyranthes aspera Linn. against glucose-induced cataractogenesis using goat lenses. J Nat Prod Plant Resour 2012; 2(1):153-61.

Nwosu FO, Nnanna LA, Okeoma KB. Corrosion inhibition for mild steel in 0.5 M H2SO4 solution using Achyranthes aspera L. leaf extract. Afr J Pure Appl Chem 2013; 7(2):56-60.

Neogi NC, Garg RD, Rathor RS. Preliminary pharmacological studies on achyranthine. Indian J Pharm 1970; 32:43-6.

Goli VT, Macharla SP, Gowrishankar NL, CH Dhanalakshmi, Bhaskar J, Bhaskar KV. Anti-pyretic activity of Achyranthes aspera Linn. pharmanest. Int J Adv Pharm Sci 2011; 2(2-3):204-6.

Mangal A, Sharma MC. Evaluation of certain medicinal plants for antiobesity properties. Indian J Traditional Knowledge 2009; 8(4):602-5.

Rani N, Sharma SK, Vasudeva N. Assessment of antiobesity potential of achyranthes aspera linn Seed. Evidence-Based Complementary Altern Med 2012; 1-7.

Datir SB, Ganjare AB, Nirmal SA, Bhawar SB, Bharati DK, Patil MJ. Evaluation of antiallergic activity of the various extracts of the aerial part of Achyranthes aspera Var. Porphyristachya (Wall. Ex MOQ.) Hook. F. Pharmacologyonline 2009; 3:921-5.

Gokhale AB, Damre AS, Kulkami KR, Saraf MN. Preliminary evaluation of anti-inflammatory and anti-arthritic activity of S. lappa, A. speciosa and A. aspera. Phytomed 2002; 9(5):433-7.

Chakraborty A, Branter A, Mukainaka T, Nobukuni Y, Kuchide M, Konoshima T, et al. Cancer chemopreventive activity of Achyranthes aspera leaves on epstein-barr virus activation and two-stage mouse skin carcinogenesis. Cancer Lett 2002; 177(1):1-5.

Geetha P, Narayanan KR, Murugesan AG. Screening the anti-cancerous efficacy of achyranthes aspera linn. using animal model swiss albino mice. J Biomed Sci Res 2010; 2(4):231-5.

Arora S, Tandon C, Tandon S. Evaluation of the cytotoxic effects of CAM therapies: an in vitro study in normal kidney cell lines. Sci World J 2014; 1-11.

Kartik R, Rao CV, Trivedi SP, Pushpangadan P, Reddy GD. Amelioration effect against N-nitrosodiethylamine and CCl4-induced hepatocarcinogenesis in Swiss albino rats by whole plant extract of Achyranthes aspera. Indian J Pharmacol 2010; 42(6):370-5.

Kumar PS, Sucheta S, Umamaheswari A, Deepa VS. In vitro and in vivo evaluation of anti-dandruff activity of formulated polyherbal hair oil. J Pharm Res 2010; 3(12):2956-8.

Barua CC, Talukdar A, Begum SA, Buragohain B, Roy JD, Borah RS, et al. Antidepressant-like effects of the methanolic extract of Achyranthes aspera Linn. in animal models of depression. Pharmacologyonline 2009; 2:587-94.

Zambare M, Uma A Bhosale, Somani RS, Yegnanarayan R, Talpate KA. Effect of Treatment with Achyranthes aspera (Agadha) ethanol extract on various hematological and biochemical parameters in alloxan induced diabetic rats. Int J Pharm Front Res 2011; 1(1):42-52.

Kumar AS, Gnananath K, Gande S, Goud ER, Rajesh P, Nagarjuna S. Anti diabetic activity of ethanolic extract of achyranthes aspera leaves in streptozotocin induced diabetic rats. J Pharm Res 2011; 4(7):3124-5.

Vidhya R, Gandhi GR, Jothi G, Radhika J, Brindha P. Evaluation of antidiabetic potential of Achyranthes aspera Linn. on alloxan induced diabetic animals. Int J Pharm Pharm Sci 2012; 4(5):577-80.

Jeyasankar A, Premalatha S, Elumalai K. Antifeedant and insecticidal activities of selected plant extracts against Epilachna beetle, Henosepilachna vigintioctopunctata (Coleoptera: Coccinellidae). Adv Entomol 2014; 2(1):14-9.

Sandhyakumary K, Body RG, Indira M. Impact of feeding ethanolic extract of Achyranthes aspera Linn. on reproductive function in male rats. Indian J Exp Biol 2002; 40:1307-9.

Shibeshi W, Makonnen E, Zerihun L, Debella A. Effect of Achyranthes aspera L. on fetal abortion, uterine and pituitary weights, serum lipids and hormones. Afr Health Sci 2006; 6(2):108-12.

Vasudeva N, Sharma SK. Post-coital antifertility activity of Achyranthes aspera Linn Root. J Ethnopharmacol 2006; 107(2):179-81.

Pakrashi A, Mookerji N, Basak B. Effect of chromatographic fractions of the plant Achyranthes aspera Linn. on fertility in female albino mice. J Reprod Fertil 1975; 43(1):127-8.

Prasad BRG, Pathak P. Analysis of Achyranthes aspera (ash) on reproductive fitness of drosophila melanogaster. Int J Pharm Appl 2011; 2(4):225-30.

Vasudeva N, Sharma SK. Estrogenic and pregnancy interceptory effects of Achyranthes aspera Linn. root. Afr J Trad CAM 2007; 4(1):7-11.

Bodare RD, Birje KN, Bansode DL, Deshmukh AJ, Inamdar II, Mane AB, et al. Antiovulatory and antiimplantation effect of ethanolic extract of root of Achyranthes aspera Linn. in the female rat. J Cell Tissue Res 2013; 13(2):3775-8.

Neogi NC, Rathor RS, Shrestha AD, Banerjee DK. Studies on the anti-inflammatory and anti-arthritic activity of achyranthine. Ind J Pharm 1969; 1(3):37-47.

Kumar SV, Sankar P, Varatharajan R. Anti-inflammatory activity of roots of Achyranthes aspera. Pharml Biol 2009; 47(10):973-5.

Jay AN, Patel J, Semuel MR, Shabaraya AR. Antiinflammatory activity of fractionated extracts of achyranthes aspera linn leaves. J Appl Pharm Sci 2011; 01(08):188-90.

Ramachandran S, Tamarbha GS. Evaluation of intestinal anti-inflammatory effect of methanolic extract of achyranthes aspera leaves on inflammatory bowel disease in wister albino rats. World J Pharm Pharm Sci 2013; 2(5):3436-48.

Bhosale UA, Yegnanarayan R, Pophale P, Somani R. Effect of aqueous extracts of achyranthes aspera Linn. On experimental animal model for inflammation. Ancient Sci Life 2012; 31:202-6.

Vetrichelvan T, Jegadeesan M. Effect of alcohol extract of Achyranthes aspera L. on acute and subacute inflammation. Phytother Res 2003; 17(1):77-9.

Khuda F, Iqbal Z, Khan A, Zakiullah, Nasir F, Shah Y. Anti-inflammatory activity of the topical preparation of Valeriana wallichii and Achyranthes aspera leaves. Pak J Pharm Sci 2013; 26(3):451-4.

Khuda F, Iqbal Z, Khan A, Zakiullah, Shah Y, Ahmad L, et al. Evaluation of anti-inflammatory activity of selected medicinal plants of khyber pakhtunkhwa, Pakistan. Pak J Pharm Sci 2014; 27(2):365-8.

Diana KJ, George KV. In vitro studies on antilithiatic property of achyranthes aspera l. var. aspera Hook f. J Pharm Res 2012; 5(8):4366-70.

Girigaon YH, Yogini RK. A comparative antimicrobial activity of Apamarga (Achyranthes aspera Linn.) patra and beeja. Int J Res Ayurveda Pharm 2012; 3(6):876-8.

Priya CL, Kumar G, Karthik L, Rao KVB. Phytochemical composition and In vitro antioxidant activity of Achyranthes aspera Linn. (Amaranthaceae) leaf extracts. J Agri Technol 2012; 8(1):143-56.

Peter TA, Usha M, Naveen S. Sunlight induced rapid synthesis and kinetics of silver nanoparticles using leaf extract of Achyranthes aspera L. and their antimicrobial applications. Adv Mat Lett 2013; 4(10):779-85.

Thilagavathi G, Kannaian T. Application of prickly chaff (achyranthes aspera linn.) leaves as herbal antimicrobial finish for cotton fabric used in healthcare textiles. J Nat Prod Resour 2008; 7(4):330-34.

Elumalai EK, Chandrasekaran N, Thirumalai T, Sivakumar C, Therasa SV, David E. Achyranthes aspera leaf extracts inhibited fungal growth. Int J Pharm Tech Res 2009; 1(4):1576-9.

Shendkar CD, Chandrachood PS, Lavate SM, Kunchiraman BN, Deshpande NR. Comparative evaluation of achyranthes aspera linn. parts by antibacterial activity. J Pharm Res 2012; 5(1):102-3.

Patil U, Sarma MC. Study of antibacterial effect of apamarga (Achyranthes aspera) on multi drug resistant clinical isolates. Int J Res Ayurveda Pharm 2013; 4(2):262-5.

Beaulah AG, Sadiq MA, Santhi RJ. Antioxidant and antibacterial activity of Achyranthes aspera: an in vitro study. Ann Biol Res 2011; 2(5):662-70.

Pandey R, Sambasivarao Y, Gurumurthy. Antibacterial activity of medicinal plants against pathogens from extracts of achyranthes aspera. Med Aromat Plants 2013; 2(5):1-3.

Pandey G, Rao CV, Gupta SS, Verma KK, Singh M. Antioxidant and antibacterial activities of leaf extract of achyranthes aspera linn. (Prickly Chaff Flower). Eur J Med Plants 2014; 4(6):695-708.

Dash BK, Sen MK, Alam MK. In vitro inhibitory activity of Achyranthes aspera L. seed against some test bacteria. Am J Life Sci 2013; 1(3):113-6.

Prasad SHKR, Swapna NL, Anthonamma K, Madanprasad RD. Antimicrobial activity of Achyranthes aspera and Aerva lanata leaf and callus extracts. Biosci Biotechnol Res Asia 2009; 6(2):887-91.

Khera N, Thakur Y, Bhati A. Diversity in antimicrobial activity of some medicinal plants of High Altitude area: achyranthes aspera, Thalictrum foliolosum, Valeriana wallichii, Hedychium spicatum, Woodfordia fruticosa, Acorus calamu, Eupatorium cannabium. Asian J Plant Sci Res 2012; 2(5):638-42.

Parmar KA, Prajapati SN, Chauhan VV, Patel CR. Preliminary phytochemical, pharmacognostical and microbial screening of achyranthes aspera (amaranthaceae). J Nat Prod Plant Resour 2013; 3(1):15-7.

Sharma S, Shrivastava PN, Saxena RC. Antimicrobial activity of saponins isolated from Achyranthes aspera against Stephylococcus aureus. Asian J Chem 2006; 18(4):2766-70.

Gupta RN, Viswas K, Pathak M, Parihar SS, Gupta A. Antibacterial activities of ethanolic extracts of plants used in folk medicine. Int J Res Ayurveda Pharm 2010; 1(2):529-35.

Kumar SS, Perumal P, Boopathy D, Mukherjee PK, Suresh B. Comparative microbiological activities of ethanolic extracts of roots and aerial parts of Achyranthes aspera linn. Anc Sci Life 2003; 22(4):140-5.

Ashokkumar P, Rajkumar, Kanimozhi M. Phytochemical screening and antimicrobial activity from five Indian medicinal plants against human pathogens. Middle East J Sci Res 2010; 5(6):477-82.

Rama Mohan Reddy T, karunakar B, Vidyasagar PG. Seed volatile oil analysis and In vitro antimicrobial activity of potential medicinal herb: Achyranthes aspera (Willd). Int J Pharm Tech 2011; 3(1):1860-6.

Narendhiran S, Saravanan L, Arun J, priyadharshini N, Sundari G, Swetha S, et al. Preliminary screening of aqueous and solvent extracts from Achyranthes aspera its antibacterial and antifungal activity. Int J Res Biol Sci 2014; 4(1):16-9.

Kalayou S, Haileselassie M, Gebre-egziabher G, Tiku’e T, Sahle S, Taddele H, et al. In-vitro antimicrobial activity screening of some ethnoveterinary medicinal plants traditionally used against mastitis, wound and gastrointestinal tract complication in Tigray Region, Ethiopia. Asian Pac J Trop Biomed 2012; 2(7):512-22.

Kaur M, Thakur Y, Rana RC. Antimicrobial properties of achyranthes aspera. Anc Sci Life 2005; 24(4):168-73.

Arunkumar S, Muthuselvam M, Rajasekaran R. Analysis of phytochemical constituents and antimicrobial activity of some Southern India medicinal plants. J Pharm Res 2010; 3(8):1841-3.

Khan MTJ, Ahmad K, Alvi MN, Amin NU, Mansoor B, Saeed MA, et al. Antibacterial and irritant activities of organic solvent extracts of agave americana linn., albizzia lebbek benth. achyranthes aspera linn. and abutilon indicum linn-a preliminary investigation. Pak J Zool 2010; 42(1):93-7.

Barua CC, Talukdar A, Begum SA, Handique AK, Handique GK, Roy JD, et al. Impact of Achyranthes aspera L. on protein profile in impaired wound models. Indo Global J Pharm Sci 2011; 1(1):13-24.

Bhosale UA, Yegnanarayan R, Pophale PD, Zambare MR, Somani RS. Study of central nervous system depressant and behavioral activity of an ethanol extract of Achyranthes aspera (Agadha) in different animal models. Int J App Basic Med Res 2011; 1:104-8.

Sharma V, Chaudhary U, Singh R, Janmeda P. Evalution of quantitative and antioxidant activity of Achyranthes aspera roots and inflorescences. Asian J Pharm 2014; 8(1):1-7.

Edwin S, Jarald E, Edwin DL, Jain A, Kinger H, Dutt KR, et al. Wound healing and antioxidant activity of achyranthes aspera. Pharm Biol 2008; 46(12):824-8.

Deshmukh JYVN, Shewale VV, Narkhede MR, Aurangabadkar VM. In vitro antioxidant activity of Achyranthes aspera L. J Pharm Res 2009; 2(9):1402-3.

Kumar A, Kumari NS, Bhargavan D. Evaluation of In vitro antioxidant potential of ethanolic extract from the leaves of Achyranthes aspera. Asian J Pharm Clin Res 2012; 5(3):146-8.

Anand M, Selvaraj V, Alagar M. Phytochemical screening and evaluation of (In vitro) antioxidant activity of Achyranthes aspera linn. root extract. Int J Pharm Pharm Sci 2014; 6(2):197-9.

Inbaneson SJ, Ravikumar S, Suganthi P. In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along palk strait against plasmodium falciparum. Asian Pac J Trop Biomed 2012; 2(5):364-7.

Rao YV, Chakrabarti R. Enhanced anti-proteases in Labeo rohita fed with diet containing herbal ingredients. Indian J Clin Biochem 2004; 19(2):132-4.

Deshmukh VN, Nehete JY, Shewale VV, Raghav NA, Gawande VT. Gastric antiulcer activity of Achyranthes aspera L. roots in pylorus ligated rats. Global J Pharmacol 2011; 5(3):143-6.

Gopinath P, Kumar MC, Kumar SM. Antiulcer and antioxidant potential of aqueous extracts of Annona squamosa and Achyranthes aspera in aspirin plus pyloric ligation model in rat. J Biotechnol Biomater 2012; 2(6):320.

Mukherjee H, Ojha D, Bag P, Chandel HS, Bhattacharyya S, Chatterjee TK, et al. Anti-herpes virus activities of Achyranthes aspera: an indian ethnomedicine, and its triterpene acid. Microbiol Res 2013; 68(4):238-44.

Gupta SS, Bhagwat AW, Ram AK. Cardiac stimulant activity of the saponin of Achyranthes aspera (Linn.). Indian J Med Res 1972; 60(3):462-71.

Ram AK, Bhagwat AW, Gupta SS. Effect of the saponin of Achyranthes aspera on the phosphorylase activity of rat heart. Indian J Physiol Pharmacol 1971; 15(3):107-10.

Neogi NC, Garg RD, Rathor RS. Preliminary pharmacological studies on achyranthine. Indian J Pharm 1970; 32(2):43.

Jahan N, Ahmad R, Hussain F. Evaluation of diuretic activity of Achyranthes aspera (Chirchita) in Goats. Pakistan Vet J 2002; 22(3):124-7.

Srivastav S, Singh P, Jha KK, Mishra G, Srivastava S, Karchuli MS, et al. Diuretic activity of whole plant extract of Achyranthes aspera Linn. Eur J Exp Biol 2011; 1(2):97-102.

Sutar N, Kumar AD, Mishra SK, Goyal P, Mishra SS. Diuretic activity of Achyranthes aspera leaves extract. Int Res J Pharm 2012; 3(4):216-8.

Chandaka M, Brainard PJ, Raj GP, Raj KR, Nishanth J, Reddy TA. Anti urolithic activity of aqueous extract on roots and seeds of Achyranthes aspera on ethylene glycol induced kidney stones in male albino rats. Int J Adv Pharm Sci 2012; 3(3-4):186-95.

Gupta SS, Verma SCL, Ram AK, Tripathi RM. Diuretic effect of the Achyranthes aspera (apamarga). Ind J Pharmac 1972; 4(4):208-14.

Das AK, Bigoniya P, Verma NK, Rana AC. Gastroprotective effect of Achyranthes aspera linn. Leaf on rats. Asian Pac J Trop Med 2012; 5(3):197-201.

Bafna AR, Mishra SH. Effect of methanol extract of Achyranthes aspera linn. On rifampicin induced hepatotoxicity in rats. Ars Pharm 2004; 45(4):343-51.

Manjunatha BK, Abhilash N, Hegde V, Suchitra MN, Vidya SM. Hepatoprotective potency of achyranthes aspera: an in-vivo study. Int J Pharm Phytopharmacol Res 2012; 1(6):387-90.

Chaitanya AKD, Challa SR, Reddy AM. Hepatoprotective effect of biherbal ethanolic extract against paracetamol-induced hepatic damage in albino rats. J Ayurveda Integr Med 2012; 3(4):198-203.

Kumar SVS, Chandrika G, Mahesh K, Meghanath PVS. Hepatoprotective activity of Achyranthes aspera linn against paracetamol induced toxicity. Int J Pharm Pharm Sci 2012; 4(5):299-302.

Sudha A, Srinivasan P, Manikandaselvi S, Thinagarbabu R. Protective effect and antioxidant role of Achyranthus aspera L. against ethanol-induced oxidative stress in rats. Int J Pharm Pharm Sci 2012; 4(3):280-4.

Akhtar MS, Iqbal J. Evaluation of the hypoglycaemic effect of Achyranthes aspera in normal and alloxan-diabetic rabbits. J Ethnopharmacol 1991; 31(1):49-57.

Talukder FZ, Khan KA, Uddin R, Jahan N, Alam MA. In vitro free radical scavenging and anti-hyperglycemic activities of Achyranthes aspera extract in alloxan-induced diabetic mice. Drug Discov Ther 2012; 6(6):298-305.

Kabir MS, Hamid K, Bulbul L, Khatun Z, Alam MZ, Chakma P. Effect of ardhabilva kvatha curna-An ayurvedic formulation on lipid profile after chronic administration. Agric Biol J N Am 2010; (5):812-6.

Latha BP, Vijaya T, Reddy IRM, Ismail M, Rao SD. Therapeutic efficacy of Achyranthes aspera saponin extract in high fat diet induced hyperlipidaemia in male wistar rats. Afr J Biotechnol 2011; 10(74):17038-42.

Venkatalakshmi P, Valli NV, Sangeetha S. Hypolipidemic effect of Achyranthes aspera on High fat diet induced atherogenic rats. Res J Pharm Biol Chem Sci 2012; 3(3):75-84.

Krishnakumari S, Priya K. Hypolipidemic efficacy of achyranthes aspera on lipid profile in sesame oil fed rats. Anc Sci Life 2006; 25(3-4):49-56.

Khanna AK, Chander R, Singh C, Srivastava AK, Kapoor NK. Hypolipidemic activity of Achyranthes aspera linn. In normal and triton induced hyperlipemic rats. Indian J Exp Biol 1992; 30(2):128-30.

Rao VY, Chakrabarti R. Stimulation of immunity in Indian major carp Catla catla with herbal feed ingredients. Fish Shellfish Immunol 2005; 18:327-34.

Bagavan A, Rahuman AA, Kamaraj C, Geetha K. Larvicidal activity of saponin from Achyranthes aspera against aedes aegypti and culex quinquefasciatus (Diptera: Culicidae). Parasitol Res 2008; 103:223-9.

Khandagle AJ, Tare VS, Raut KD, Morey RA. Bioactivity of essential oils of Zingiber officinalis and Achyranthes aspera against mosquitoes. Parasitol Res 2011; 109:339-43.

Chalannavar RK, Hurinanthan V, Singh A, Venugopala KN, Gleiser RM, Baijnath H, et al. The antimosquito properties of extracts from flowering plants in South Africa. Trop Biomed 2013; 30(4):559-69.

Kumar S, Wahab N, Mishra M, Warikoo R. Evaluation of 15 local plant species as larvicidal agents against an Indian strain of dengue fever mosquito, Aedes aegypti L. (Diptera: Culicidae). Front Physiol 2012; 3(104):1-6.

Jayakumar T, Sridhar MP, Bharath Prasad TR, Ilayaraja M, Govindasamy S, Balasubramanian MP. Experimental studies of Achyranthes aspera (L) preventing nephrotoxicity induced by lead in albino rats. J Health Sci 2009; 55(5):701-8.

Aggarwal A, Single SK, Gandhi M, Tandon C. Preventive and curative effects of Achyranthes aspera Linn exract in experimentally induced nephrolithiasis. Indian J Exp Biol 2012; 50:201-8.

Tahiliani P, Kar A. Achyranthes aspera elevates thyroid hormone levels and decreases hepatic lipid peroxidation in male rats. J Ethnopharmacol 2000; 1(3):527-32.

Anuja MM, Nithya RS, Swathy SS, Rajamanickam C, Indira M. Spermicidal action of a protein isolated from ethanolic root extracts of Achyranthes aspera: an In vitro study. Phytomed 2011; 18(8-9):776-82.

Anuja MNMK, Nithya RNSA, Rajamanickam C, Madambath I. Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative study with gossypol. Contracept 2010; 82(4):385-90.

Pakrashi A, Bhattacharya N. Abortifacient principles of Achyranthes aspera L. Indian J Exp Biol 1977; 15(10):856-85.

Paul D, Bera S, Jana D. In vitro determination of the contraceptive spermicidal activity of a composite extract of Achyranthes aspera and Stephania hernandifolia on human semen. Contracept 2006; 73(3):284-8.

Paul D, Debasis D, Ali KM, Chatterjee K, Nandi DK, Ghosh D. Comparative study on the spermicidal activity of organic solvent fractions from hydroethanolic extracts of Achyranthes aspera and Stephania hernandifoliain human and rat sperm. Contracept 2010; 81(4):355-61.

Paul D, Mallick C, Ali KM, Nandi DK, Ghosh D. Duration dependent effect of hydro-ethanolic extract of leaf of S. hernandifolia and root of A. aspera on testicular androgenic and gametogenic activity: An approach for male herbal contraceptive development. Int J Appl Res Nat Prod 2010; 2(4):1-10.

Hossain MJ, Khaleda L, Chowdhury AMMA, Arifuzzaman M, Al-Forkan M. Phytochemical screening and evaluation of cytotoxicity and thrombolytic properties of achyranthes aspera leaf extract. IOSR J Pharm Biol Sci 2013; 6(3):30-8.

Ghosh PK, Gupta VB, Rathore MS, Hussain I. Wound-healing potential of aqueous and ethanolic extracts of apamarga leaves. Int J Green Pharm 2011; 5(1):12-5.

Gupta N, Jain UK. Wound healing potential of methanolic extract of leaves of Achyranthes aspera linn. Der Pharm Sin 2011; 2(2):256-62.

Fikru A, Makonnen E, Eguale T, Debella A, Mekonnen GA. Evaluation of In vivo wound healing activity of methanol extract of Achyranthes aspera L. J Ethnopharmacol 2012; 143(2):469-74.

Taye B, Giday M, Animut A, Seid J. Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in ethiopia. Asian Pac J Trop Biomed 2011; 1(5):370-5.

Mathur A, Sing R, Yousuf S, Bhardwaj A, Verma SK, Babu P, et al. Antifungal activity of some plant extracts against clinical pathogens. Adv Appl Sci Res 2011; 2(2):260-4.

Deshmukh GR, Kumar KH, Reddy PVS, Rao BS, Kumar CVS. Evaluation of eye irritation potential of aqueous leaf extract of achyranthes aspera by in vitro and in vivo method. ISRN Toxicol 2012; 1

Sadashiv PS, Krishna AR. Acute toxicity study for Achyranthes aspera leaves. J Pharm Res 2011; 4(7):2221-2.

Dwivedi SN. Herbal remedies among tribals of sidhi district of Madhya Pradesh. J Econ Tax 2004; 28(3):675-86.

Nadkarni KM. Indian Materia medica, Vol-I, 3rd ed. Bombay popular prakashan; 2005. p. 21-2.

Rangari VD. Pharmacognocy and phytochemistry Part II, Ist edition, Carrer publication; 2006. p. 179-80.

Jain SK, Tarafdar CR. Medicinal plant lore of the sandals. A review of P. O. Bodding‘s work. Econ Bot 1970; 24(3):241-75.

Chopra RN. Indigenous drug of India, Calcutta; 1933.

Gopalanchari R, Dhar ML. Studies in the constitution of the saponin from the seeds of Achyranthes aspera: Part 1-identification of the sapogenins. J Sci Indust Res 1985; 17(B):276-8.

Quisumbing E. Medicinal Plants of the Philippines Tech Bull, Phillips Dep. Agri Natur Res, 16, Manila, Philippine Islands: Manila Bureau of Printing; 1951.

Rao RR. Ethnobotany of Meghalaya: medicinal plants used by khasi and garo tribes. Econ Bot 1981; 35(1):4-9.

Malhi BS, Trivedi VP. Vegetable antifertility drug of India. Quert crude Drug Res 1972; 12(3):1922-8.

Dwivedi SN. Ethnobotanical studies and conservational strategies of wild and natural resources of rewa district of madhya pradesh. J Econ Tax Bot 2003; 27(1):233-4.

Dwivedi SN, Shrivastava S, Dwivedi S, Dwivedi A, Dwivedi S, Kaul S. Relivance of medicinal herbs used in traditional system of medicine, Farmavita Net; 2007.

About this article





Additional Links

Manuscript Submission


Journal of Critical Reviews
Vol 2, Issue 1, 2015 Page: 7-19

Online ISSN


Authors & Affiliations

Veena Sharma
Banasthali University

Urmila Chaudhary
Banasthali University


  • There are currently no refbacks.