CHROMATOGRAPHIC METHOD FOR IRBESARTAN AND ITS COMBINATION WITH OTHER DRUG


Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

Abstract


Chromatographic method is most useful analytical method that gives estimation, impurity profiling, assay and compedial method for single and combination of drug. Irbesartan is classified as an angiotensin II receptor type 1 antagonist. Angiotensin II receptor type 1 antagonists are widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamics and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers the most recent many chromatographic methodsincludingResidue by HPLC, HPTLC, RP HPLC and liquid chromatography tendam mass spectroscopy were reported.

Keyword: Irbesartan, Analytical Method, HPLC, Anti hypertensive drug, Angiotensin II receptor antagonist.


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About this article

Title

CHROMATOGRAPHIC METHOD FOR IRBESARTAN AND ITS COMBINATION WITH OTHER DRUG

Date

31-03-2015

Additional Links

Manuscript Submission

Journal

Journal of Critical Reviews
Vol 2, Issue 2, 2015 Page: 7-11

Online ISSN

2394-5125

Statistics

672 Views | 308 Downloads

Authors & Affiliations

Paras Virani
Research Scholar 2014, Gujarat Technological University, Gujarat
India

Rajanit Sojitra

Hasumati Raj

Vineet Jain


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