SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT


RUBENDRA KURMI, DINESH KUMAR MISHRA, DINESH KUMAR JAIN

Abstract


Poor solubility of drugs is a major challenge in the formulation development. Solid dispersion is introduced as a novel means for enhancement of solubility. Solid dispersion may be defined as a set of solid products comprising of at least two diverse components, usually hydrophilic matrix and hydrophobic drug. This matrix may be crystalline or amorphous in nature. As per biopharmaceutical classification system class II drugs are with low solubility and high permeability and are the promising candidates for improvement of solubility as well as bioavailability by means of solid dispersion. Practical aspects pertaining to preparation of solid dispersions, like the selection of carrier, drugs molecular arrangement in these preparations are discussed in this article. Proposed article highlights the various preparation techniques of solid dispersion, characterization, available recent technologies, marketed preparation, future prospective etc.

Keywords: Matrix, Solubility, Carrier, Solid dispersion.


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About this article

Title

SOLID DISPERSION: A NOVEL MEANS OF SOLUBILITY ENHANCEMENT

Date

05-01-2016

Additional Links

Manuscript Submission

Journal

Journal of Critical Reviews
Vol 3, Issue 1, 2016 Page: 1-8

Online ISSN

2394-5125

Statistics

361 Views | 1138 Downloads

Authors & Affiliations

RUBENDRA KURMI
IPS Academy, College of Pharmacy Indore (M. P.) Pin 452012

DINESH KUMAR MISHRA
IPS Academy, College of Pharmacy Indore (M. P.) Pin 452012
India

DINESH KUMAR JAIN
IPS Academy, College of Pharmacy Indore (M. P.) Pin 452012


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