• Devesh Kapoor Dr. Dayaram Patel Pharmacy College, India


Diverse classes of pharmaceutical compounds like analgesic, antidepressant, antihypertensive, contraceptive, antibiotic, steroids and hormones etc. have been detected in water samples from ng/l to μg/l range. Though the detected amounts are very tiny but highly toxic for human, animal and aquatic lives. Traditional wastewater treatment methods, such as activated sludge, are not sufficient for the complete removal of active pharmaceutical ingredients and other wastewater constituents from these waters. Environment and health are directly or indirectly affected by pharmaceutical effluents especially in the vicinity of pharma industrial zones. Pharmaceutical waste is a form of medical waste that includes unused medications, and occasionally frills such as used test strips, and other supplies. Pharmaceuticals are synthetic chemicals belonging to a wide group of different chemical families and may also react different in the environment. Pharmaceuticals are special kinds of chemicals. They are manufactured to be biologically active in living organisms, to be persistent to biodegradation and to have long half-lives. This makes them more risky in nature. Release is ongoing always and everywhere, diffuse and impossible to control. They cannot be forbidden. There is a need of regular monitoring of concentration of pharmaceutical compounds in pharmaceutical effluents entering into drinking water sources in order to save environment as well as living form of lives from health hazards. The present paper highlights such toxicity, health risk and assessment of environmental hazards due to pharmaceutical pollutants.

Keywords: Pharmaceutical waste, Industrial wastewater, Health Hazards, Drinking water sources, Biomedical waste.


1. WHO. Available from: URL: sanitation_health/emerging/info_sheet_ pharmaceuticals/en/index.html. [Last accessed on 05 Jun 2013].
2. Larsson DGJ, De PC, Paxéus N. Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 2007;148:751–5.
3. Shafir W. Pharmaceutical waste: why is it an issue now? Environmental Protection Agency. Available from: URL: [Last accessed on 05 Jun 2013].
4. Bruce GM, Pleus RC, Snyder SA. Toxicological relevance of pharmaceuticals in drinking water. Environ Sci Technol 2010;44:5619–26.
5. Kolpin DW, Furling ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in U. S. streams, 1999–2000: a national reconnaissance. Environ Sci Technol 2002;36:1202–11.
6. Ministry of environment and forests, notification, New Delhi; 1998.
7. Lee KE, Barber LB, Furlong ET. Presence and distribution of organic wastewater compounds in waste water, surface, ground, and drinking waters, Minnesota 2000–2002, Reston, VA: U. S. Geo-logical Survey; 2004.
8. Daughton CG, Ternes TA. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 1999;107:907–37.
9. Kolpin DW, Furlong ET, Meyer MY. Pharmaceuticals, hormones, and other organic waste water contaminants in U.S. streams, 1999–2000: a national reconnaissance. Environ Sci Technol 2002;36:1202–11.
10. Kuspis DA, Krenzelok EP. What happens to expired medications? A survey of community medication disposal. Vet Hum Toxicol 1996;38:48–9.
11. Heberer T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 2002;131:5–17.
12. Smith CA. Managing pharmaceutical waste. J Pharm Soc Wisc 2002;6:17–22.
13. FEPA (Federal Environmental Protection Agency). FG Press: Lagos Nigeria; 1992. p. 238.
14. Ezenobi NO, Okpokwasili GC. Bacterial flora and physico-chemical characteristics of hospital sewage in port harcourt city. Nigerian J Microbiol 2004;18:277.
15. Pratyusha K, Nikita M, Gaikwad AA, Phatak PD, Chaudhari PE. Society’s modern college of pharmacy, Nigdi, Pune 411044 (Maharashtra), India. Review on: waste material management in pharmaceutical industry; 2012. p. 121-9.
16. Crane M, Watts C, Boucard T. Chronic aquatic environmental risks from exposure to human pharmaceuticals. Sci Total Environ 2006;367:23-41.
17. Quinn B, Gagne F, Blaise C. An investigation into the acute and chronic toxicity of eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, Hydra attenuata. Sci Total Environ 2008;389:306-14.
18. Gaworecki KM, Klaine SJ. Behavioral and biochemical responses of hybrid striped bass during and after fluoxetine exposure. Aquat Toxicol 2008;88:207-13.
19. Stanley JK, Ramirez AJ, Chambliss CK, Brooks BW. Enantiospecific sublethal effects of the antidepressant fluoxetine to a model aquatic vertebrate and invertebrate. Chemosphere 2007;69:9-16.
20. Brooks BW, Turner PK, Stanley JK, Weston JJ, Glidewell EA, Foran CM, et al. Waterborne and sediment toxicity of fluoxetine to select organisms. Chemosphere 2003;52:135-42.
21. Sharma N. Pharmaceutical Waste Management: A Challenge to Make Environment Eco-Friendly; 2010. p. 332-8.
22. Managing pharmaceutical waste: a 10-step blueprint for health care facilities in the United States. Hospitals for a Healthy Environment. Available from: URL: [Last accessed on 05 Jun 2013]
23. Ashraf MA, Maah MJ, Yusoff I, Mehmood K. Effects of polluted water irrigation on environment and health of people in Jamber, District Kasur, Pakistan. Int J Basic Appl Sci 2010;10:37-57.
24. Avdeev O, Korchagin P. Organization and implementation of contaminated waste neutralization in the Ukraine-National Report II, Central. Eur J Public Health 1994;2:51-2.
25. Blaxill MF. What's going on? The question of time trends in autism. Public Health Reports 2004;119:536-51.
26. Brauer M, Hoek G, Smith HA, de Jongste JC, Gerritsen J. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Soc Clin Res Physiol 2007;29:879-88.
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How to Cite
Kapoor, D. (2015). IMPACT OF PHARMACEUTICAL INDUSTRIES ON ENVIRONMENT, HEALTH AND SAFETY. Journal of Critical Reviews, 2(4), 25-30. Retrieved from
Pharmaceutical Sciences