RECENT ADVANCES IN MICROSPONGES DRUG DELIVERY SYSTEM
Microsponge technology has been introduced in topical drug products to facilitate the controlled release of active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active drugs. Microsponges consist of microporous beads, typically 10-25 microns in diameter, loaded with active agent. When applied to the skin, the microsponge releases its active ingredient on a time mode and also in response to other stimuli (rubbing, temperature, pH, etc) that are used mostly for topical and recently for oral administration. Microsponge technology has many favorable characteristics which make it a versatile drug delivery vehicle. Microsponge systems can suspend or entrap a wide variety of substances, and then be incorporated into a formulated product such as a gel, cream, liquid or powder. The outer surface is typically porous, allowing the sustained flow of substances out of the sphere. Microsponge drug delivery system (MDDS) can provide increased efficacy for topically active agents with enhanced safety, extended product stability, enhanced formulation flexibility, reduced side effects and improved aesthetic properties in an efficient and novel manner. In addition these are non-irritating, non-mutagenic, non-allergenic, and nontoxic. The present review introduces Microsponge technology along with its synthesis, characterization, programmable parameters and release mechanism of MDDS.
Keywords: Controlled Drug Delivery System, Microsponge Technology, Programmable Release, Microsponge.
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