PRELIMINARY IN VIVO EVALUATION OF ANTI-INFLAMMATORY ACTIVITIES OF VARIOUS SOLVENT EXTRACTS OF CADABA INDICA LAM ON CARRAGEENAN-INDUCED PAW EDEMA IN SWISS ALBINO RATS


Ramakrishnan . N, Vijayaraghavan S, Ramarajan K, Tamizhazhagan V

Abstract


ABSTRACT
Objective: Among the invention of novel anti-inflammatory agents from modern research and drug development, the natural sources exist as
evergreen to produce potential secondary metabolites that possess multiple efficacy against inflammatory mediators with no adverse reactions.
Methods: Accordingly, Cadaba indica lam (Capparidaceae) produced the positive results for phenol, flavonoids, steroid, and saponins in preliminary
phytochemical screening and exhibited the potent anti-inflammatory activity (100 mg/kg, 200 mg/kg) by methanolic leaf extract against carrageenaninduced
paw
edema
using rats
in
dose-dependent
manner stayed
closer to
reference
standard
indomethacin (25
mg/kg)
compared
to
petroleum
ether

and
aqueous extract.
Results: Thus, the plant C. indica lam might be considered to posses potential secondary metabolites against inflammatory agents and act as lead to
isolation of novel therapeutic compounds.
Conclusion: The phytochemical test indicates the presence of phenol, flavonoids, steroid, and saponins in leaf extract of C. indica may be known to
possess anti-inflammatory property. The result of anti-inflammatory activity produced by the methanolic extract was threshold of isolation of bio
molecules from the natural sources in diverse drug development in the near future being responsible for the pharmaceutical industries.
Keywords: Preliminary phytochemical, Cadaba indica, Anti-inflammatory.


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About this article

Title

PRELIMINARY IN VIVO EVALUATION OF ANTI-INFLAMMATORY ACTIVITIES OF VARIOUS SOLVENT EXTRACTS OF CADABA INDICA LAM ON CARRAGEENAN-INDUCED PAW EDEMA IN SWISS ALBINO RATS

Date

14-03-2017

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Journal

Innovare Journal of Agricultural Sciences
VOL 5 ISSUE 2 MARCH-APRIL 2017 Page:

Online ISSN

2321-6832

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Authors & Affiliations

Ramakrishnan . N
India

Vijayaraghavan S

Ramarajan K

Tamizhazhagan V

 

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