ADVANCES IN LIPOSOMAL DRUG DELIVERY SYSTEM: FASCINATING TYPES AND POTENTIAL APPLICATIONS


Smita Bonde, Sukanya Nair

Abstract


Liposomes are an efficient novel drug delivery system. They are used because of their structure which is stable and due to their ability to accommodate both lipophilic and hydrophilic drug. Various fascinating types of liposomes have been developed in recent past to further enhance their utility. Long-circulating liposomes or stealth liposomes are able to hide from the defence system of the body and circulate for a longer time in the blood. Targeted liposomes namely immuno- liposomes consists of antibodies conjugated on their surface to improve the specificity of the cell. Liposomes have been modified as per the conditions of pH and temperature, specifically designed to improve drug delivery to targeted tumor cells. Liposomes are being used in the treatment of various diseases and there are various liposomal drug formulations available today. Liposomes can be used as carriers for genetic materials such as antisense, DNA, RNA which are useful in the treatment of diseases. Liposomes are also efficient carriers of cytokines which further activate macrophages. This review provides the detailed insight of types and applications of liposomes and the potential challenges in the development of liposomal drug delivery systems.


Keywords


Targeted, Long-circulating, pH sensitive, Cancer, Antimicrobial agent

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About this article

Title

ADVANCES IN LIPOSOMAL DRUG DELIVERY SYSTEM: FASCINATING TYPES AND POTENTIAL APPLICATIONS

Keywords

Targeted, Long-circulating, pH sensitive, Cancer, Antimicrobial agent

DOI

10.22159/ijap.2017v9i3.17984

Date

01-05-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 9, Issue 3, 2017 Page: 1-7

Online ISSN

0975-7058

Statistics

300 Views | 71 Downloads

Authors & Affiliations

Smita Bonde
SVKM’s NMIMs, School of Pharmacy and Technology Management, Shirpur Campus, Maharashtra, India
India

Sukanya Nair
SVKM’s NMIMs, School of Pharmacy and Technology Management, Shirpur Campus, Maharashtra, India
India


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