SCREENING AND OPTIMIZATION OF VALACYCLOVIR NIOSOMES BY DESIGN OF EXPERIMENTS


Surya Teja Sp, Mothilal M., Damodharan N, Jaison D

Abstract


Objective: The objective of the study was to perform a screening, optimization of valacyclovir niosomal formulation to achieve a sustained release of drug using the design of experiments by 32 full factorial design.

Methods: Valacyclovir loaded niosomes were prepared using thin film hydration method by varying the ratio of Span 60 and Cholesterol. The prepared niosomes were evaluated for vesicle size, entrapment efficiency, cumulative drug release, fourier transformed infrared spectroscopy (FTIR), zeta potential and surface morphology by field emission scanning electron microscopy (FESEM).

Results: The valacyclovir was successfully encapsulated and its entrapment efficiency ranged from 36.70 % to 50.62 %. The average vesicle size of the niosomes was found to be 431 to 623 nm. At 8th hour the drug release varied from 77.50% to 96.31 %. The optimized niosomes were multilamellar with a surface charge potential of about-43.2 mV. The studies revealed that the interaction of cholesterol and surfactant had a substantial effect on vesicle size, entrapment efficiency and drug release from the niosomes. The release kinetics of the optimized niosomes followed zero order kinetics with fickian diffusion controlled mechanism. The stability studies were performed for the optimized formulation and found that the formulation is stable at 4°C ± 2°C.

Conclusion: Model equations were developed for the responses. No significant difference was observed between the predicted and observed value, showing that the developed model is reliable.


Keywords


Design of Experiments, Full factorial design, Niosomes, Optimization, Valacyclovir

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About this article

Title

SCREENING AND OPTIMIZATION OF VALACYCLOVIR NIOSOMES BY DESIGN OF EXPERIMENTS

Keywords

Design of Experiments, Full factorial design, Niosomes, Optimization, Valacyclovir

DOI

10.22159/ijap.2018v10i1.22566

Date

06-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 10, Issue 1 (Jan-Feb), 2018 Page: 79-85

Online ISSN

0975-7058

Authors & Affiliations

Surya Teja Sp
Department of Pharmaceutics, SRM College of Pharmacy, SRM University, Chennai, India
India

Mothilal M.
Department of Pharmaceutics, SRM College of Pharmacy, SRM University, Chennai, India
India

Damodharan N
Department of Pharmaceutics, SRM College of Pharmacy, SRM University, Chennai, India
India

Jaison D
Nanotechnology Research Center, SRM University, Chennai, India
India


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