• Niranjana E. S. Department of Pharmacy Practice, J. K. K. Nattraja College of Pharmacy, Kumarapalayam 638183
  • Sambath Kumar R. Department of Pharmaceutics, J. K. K. Nattraja College of Pharmacy, Kumarapalayam 638183
  • Sudha M. Department of Pharmacology, J. K. K. Nattraja College of Pharmacy, Kumarapalayam 638183
  • Venkateswaramurthy N. Department of Pharmacy Practice, J. K. K. Nattraja College of Pharmacy, Kumarapalayam 638183



Antibiotics, Clinical development, Narrow spectrum


The world is running out of antibiotics. Between 1940 and 1962, more than 20 new classes of antibiotics were marketed. Since then, only two new classes of antibiotics were marketed. Now, not enough analogues are reaching the market to stem the tide of antibiotic resistance, particularly among gram-negative bacteria which indicates the need of novel antibiotics for their effective action. This review describes those antibiotics in late-stage clinical development. Most of them belong to existing antibiotic classes and a few with a narrow spectrum of activity are novel compounds directed against novel targets. The reasons for some of the past failures to find new molecules and a path forward to help attract investments to fund the discovery of new antibiotics are described.


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How to Cite

S., N. E., R., S. K., M., S., & N., V. (2018). REVIEW ON CLINICALLY DEVELOPING ANTIBIOTICS. International Journal of Applied Pharmaceutics, 10(3), 13–18.



Review Article(s)