GREEN METHOD FOR ACETAMINOPHEN AND IBUPROFEN SIMULTANEOUS ASSAY IN THE COMBINATION TABLET USING FTIR
Keywords:FTIR, Green method, Acetaminophen, Ibuprofen, Assay
Objective: The purpose of this study was to develop a green method for assay the tablet consists of a combination of acetaminophen (ACT)-ibuprofen (IBU). FTIR (Fourier Transform Infrared Spectroscopy), which is commonly used for qualitative analysis, was developed to measure the tablet contents, directly and quantitatively.
Methods: Standard for ACT and IBU was respectively mixed with KBr crystal in varied and measured using FTIR. The transmission spectrum yielded later was converted into its absorbance-derivatized forms which then a calibration curve was composed using the data. Once validated, the analytical method was conducted on samples of the branded ACT-IBU combination tablet.
Results: ACT had a specific wavenumber of a group N-H stretch, meanwhile IBU was represented by the C = O spectrum. These peaks then used for quantitative calculation basis levels respectively. The limits of detection and quantitation of ACT consecutively were % w/w and Â w/w and IBU were % w/w and Â w/w. Next; the method was carried out successfully to evaluate the content of sample tablet from the market.
Conclusion: The analytical method of ACT-IBU was proven applicable and suitable for the quantitative purpose. The method shows meet with the expectation such as simple and easy to perform and reduce the use of solvents.
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