• Ilma Nugrahani Institute Technology of Bandung, Jl. Ganesha No.10, Lb. Siliwangi, Coblong, Kota Bandung, Jawa Barat 40132, Indonesia
  • Farah Nur Khalida Institute Technology of Bandung, Jl. Ganesha No.10, Lb. Siliwangi, Coblong, Kota Bandung, Jawa Barat 40132, Indonesia



FTIR, Green method, Acetaminophen, Ibuprofen, Assay


Objective: The purpose of this study was to develop a green method for assay the tablet consists of a combination of acetaminophen (ACT)-ibuprofen (IBU). FTIR (Fourier Transform Infrared Spectroscopy), which is commonly used for qualitative analysis, was developed to measure the tablet contents, directly and quantitatively.

Methods: Standard for ACT and IBU was respectively mixed with KBr crystal in varied and measured using FTIR. The transmission spectrum yielded later was converted into its absorbance-derivatized forms which then a calibration curve was composed using the data. Once validated, the analytical method was conducted on samples of the branded ACT-IBU combination tablet.

Results: ACT had a specific wavenumber of a group N-H stretch, meanwhile IBU was represented by the C = O spectrum. These peaks then used for quantitative calculation basis levels respectively. The limits of detection and quantitation of ACT consecutively were % w/w and  w/w and IBU were % w/w and  w/w. Next; the method was carried out successfully to evaluate the content of sample tablet from the market.

Conclusion: The analytical method of ACT-IBU was proven applicable and suitable for the quantitative purpose. The method shows meet with the expectation such as simple and easy to perform and reduce the use of solvents.


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How to Cite

Nugrahani, I., & Khalida, F. N. (2018). GREEN METHOD FOR ACETAMINOPHEN AND IBUPROFEN SIMULTANEOUS ASSAY IN THE COMBINATION TABLET USING FTIR. International Journal of Applied Pharmaceutics, 10(3), 77-85.



Original Article(s)