GREEN METHOD FOR ACETAMINOPHEN AND IBUPROFEN SIMULTANEOUS ASSAY IN THE COMBINATION TABLET USING FTIR


Ilma Nugrahani, Farah Nur Khalida

Abstract


Objective: The purpose of this study was to develop a green method for assay the tablet consists of a combination of acetaminophen (ACT)-ibuprofen (IBU). FTIR (Fourier Transform Infrared Spectroscopy), which is commonly used for qualitative analysis, was developed to measure the tablet contents, directly and quantitatively.

Methods: Standard for ACT and IBU was respectively mixed with KBr crystal in varied and measured using FTIR. The transmission spectrum yielded later was converted into its absorbance-derivatized forms which then a calibration curve was composed using the data. Once validated, the analytical method was conducted on samples of the branded ACT-IBU combination tablet.

Results: ACT had a specific wavenumber of a group N-H stretch, meanwhile IBU was represented by the C = O spectrum. These peaks then used for quantitative calculation basis levels respectively. The limits of detection and quantitation of ACT consecutively were % w/w and  w/w and IBU were % w/w and  w/w. Next; the method was carried out successfully to evaluate the content of sample tablet from the market.

Conclusion: The analytical method of ACT-IBU was proven applicable and suitable for the quantitative purpose. The method shows meet with the expectation such as simple and easy to perform and reduce the use of solvents.


Keywords


FTIR, Green method, Acetaminophen, Ibuprofen, Assay

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About this article

Title

GREEN METHOD FOR ACETAMINOPHEN AND IBUPROFEN SIMULTANEOUS ASSAY IN THE COMBINATION TABLET USING FTIR

Keywords

FTIR, Green method, Acetaminophen, Ibuprofen, Assay

DOI

10.22159/ijap.2018v10i3.23034

Date

08-05-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 10, Issue 3 (May-Jun), 2018 Page: 77-85

Online ISSN

0975-7058

Authors & Affiliations

Ilma Nugrahani
Institute Technology of Bandung, Jl. Ganesha No.10, Lb. Siliwangi, Coblong, Kota Bandung, Jawa Barat 40132, Indonesia
Indonesia

Farah Nur Khalida
Institute Technology of Bandung, Jl. Ganesha No.10, Lb. Siliwangi, Coblong, Kota Bandung, Jawa Barat 40132, Indonesia


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