THE ENHANCEMENT EFFECT OF CASTOR OIL ON THE PERMEABILITY OF FLURBIPROFEN AS TRANSDERMAL GEL


Maryam Alaayedi, Hasanain Mahmood, Ashti Saeed

Abstract


Objective: The object of this study was to improve flurbiprofen permeability transdermally using castor oil as penetration enhancer.

Methods: Castor oil with different concentrations (1%, 2%, 3%, 4%, and 5%) was used in this study as a natural enhancer to improve flurbiprofen permeation transdermally as a gel. The formulated gel of the drug was evaluated for several physicochemical characteristics. The in vitro release and permeability studies for the drug were performed using Franz cell diffusion apparatus across the synthetic membrane. Korsmeyer Pappas kinetic model was used to study the release mechanism of flurbiprofen from the gel.

Results: The results demonstrated that castor oil was safe with no skin irritation and the formulas were stable over time. Castor oil was significantly effective in increasing the percent of flurbiprofen permeability from 46%±2.9 for the gel without enhancer to 95%±2 for the gel with 5% castor oil and increasing its penetration is directly related to the oil concentration. Two mechanisms for the drug release from the gel were involved, which are non-Fickian (anomalous) and super case II transport.

Conclusion: Flurbiprofen gel was prepared and evaluated successfully for an in vitro parameters with a good permeation across a synthetic membrane. The results demonstrated that castor oil had an effective enhancement for permeation of flurbiprofen.


Keywords


Gel, Transdermal, Flurbiprofen, Permeability, Enhancer, Castor oil

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About this article

Title

THE ENHANCEMENT EFFECT OF CASTOR OIL ON THE PERMEABILITY OF FLURBIPROFEN AS TRANSDERMAL GEL

Keywords

Gel, Transdermal, Flurbiprofen, Permeability, Enhancer, Castor oil

DOI

10.22159/ijap.2018v10i1.23348

Date

06-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 10, Issue 1 (Jan-Feb), 2018 Page: 140-144

Online ISSN

0975-7058

Statistics

139 Views | 23 Downloads

Authors & Affiliations

Maryam Alaayedi
College of Pharmacy/ University of Kerbala, Kerbala, Iraq,
Iraq

Hasanain Mahmood
College of Pharmacy/ University of Kerbala, Kerbala, Iraq
Iraq

Ashti Saeed
College of Pharmacy/ University of Kerbala, Kerbala, Iraq
Iraq


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