FORMULATION DEVELOPMENT AND EVALUATION OF ALLOPURINOL SOLID DISPERSIONS BY SOLVENT EVAPORATION TECHNIQUE


Ramshetti Rajendra Prasad, Jadi Rajendra Kumar, Bakshi Vasudha, Chettupalli Ananda Kumar

Abstract


Objective: The main objective of the research work is to develop and characterize allopurinol (ALPN) solid dispersions with different polymers to enhance solubility, enrich dissolution profile and improve patient compliance.

Methods: ALPN solid dispersions were prepared by solvent evaporation technique using various grades of polyethelene glycol (PEG) such as PEG 4000 and PEG 6000 with different ratios like 1:0.5, 1:1, 1:1.5 and 1:2 and after formation of solid dispersions all physicochemical properties were examined.

Results: All the formulations were found within the permissible pharmacopoeial limits for various physicochemical parameters. The pre-formulation studies, like Fourier, transform infrared spectroscopy (FTIR) showed the absence of drug-excipient interactions. The solubility and dissolution profiles of the sample were increased with increasing the concentration of ALPN solid dispersions. Solvent evaporation was proved to be a successful technique for the development of stable solid dispersion of ALPN. The dissolution amount percentage of ALPN formulations was found between 39.58±2.5 to 94.95±1.8 % within 60 min.

Conclusion: Hence, from the all evaluation studies, it was evident that F1 formulation was the better formulation. F1 formulation (ALPN: PEG 4000 in the ratio of 1:0.5), 94.95±1.8 % drug released within 50 min.

 


Keywords


Solid dispersions, Polyplasdone XL, Compressibility, Flowability

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About this article

Title

FORMULATION DEVELOPMENT AND EVALUATION OF ALLOPURINOL SOLID DISPERSIONS BY SOLVENT EVAPORATION TECHNIQUE

Keywords

Solid dispersions, Polyplasdone XL, Compressibility, Flowability

DOI

10.22159/ijap.2018v10i4.25311

Date

07-07-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 10, Issue 4 (July-Aug), 2018 Page: 168-171

Online ISSN

0975-7058

Authors & Affiliations

Ramshetti Rajendra Prasad
Chaitanya College of Pharmacy Education and Research, Kishanpura, Hanamkonda, Warangal 506001, TS, India,
India

Jadi Rajendra Kumar
Anurag Group of Institutions, School of Pharmacy, (Formerly Lalitha College of Pharmacy), Venkatapur, Ghatkesar, Medchal, Hyderabad 500088, TS, India,

Bakshi Vasudha
Anurag Group of Institutions, School of Pharmacy, (Formerly Lalitha College of Pharmacy), Venkatapur, Ghatkesar, Medchal, Hyderabad 500088, TS, India,

Chettupalli Ananda Kumar
University College of Technology, Osmania University, Hyderabad 500007, TS, India
India


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