Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Chaiyavat Chaiyasut


Aging is the inevitable biological event associated with several physiological, behavioral, and lifestyle events, but people do not wish to become old. The market for anti-aging products is growing gradually, and customers are aware of active principles in the cosmetics. The probiotics are known for several health benefits, especially probiotics regulate the gut health and immune system. Recent studies emphasized the role of probiotics, and probiotic-containing fermented products in cosmetics, and aging. The whole mechanism of aging has not been elucidated yet, but modern aging theories are in two different categories such as programmed theory and damage theory. The aging mechanisms can be discussed in organismal, and cellular level. To some extent, organismal and premature aging is controlled by genetic makeup. Though, genetic, and environmental factors impact healthy aging, diet and gut microbiota also play asignificant role in senescence. Aging is greatly associated witha diversity of gut microbiota that is often related to the changes in the gastrointestinal tract, and dietary patterns, together with an associated decline in cognitive and immune function, eventually contributing to infirmity. Lactic acid bacteria are reported for the ability to extend the lifespan and/ or healthspan. The current manuscript discussed the aging mechanisms, an association of microbiome and aging, and compiled the reported anti-aging properties of probiotics.


Aging, Anti-aging, Probiotics, Microbiome, Lifespan, Healthspan.


Bektas A, Schurman SH, Sen R, Ferrucci L. Aging, inflammation and the environment. Exp Gerontol2018;105:10-8.

Fabbri E, An Y, Zoli M, Simonsick EM, Guralnik JM, Bandinelli S, et al. Aging and the burden of multimorbidity: Associations with inflammatory and anabolic hormonal biomarkers. J Gerontol A Biol Sci Med Sci 2015;70:63-70.

Stepanova M, Rodriguez E, Birerdinc A, Baranova A. Age-independent rise of inflammatory scores may contribute to accelerated aging in multi-morbidity. Oncotarget 2015; 6:1414-21.

Sirilun S, Sivamaruthi BS, Kumar N, Kesika P, Peerajan S, Chaiyasut C. 2016. Lactobacillus-fermented plant juice as a potential ingredient in cosmetics: Formulation and assessment of natural mouthwash. Asian J Pharm Clin Res 2016;9(Suppl.3):52-6.

Sharma D, Kober MM, Bowe WP. Anti-aging effects of probiotics. J Drugs Dermatol 2016;15:9-12.

Sivamaruthi BS, Chaiyasut C, Kesika P. Cosmeceutical Importance of Fermented Plant Extracts: A Short Review. Int J App Pharm 2018;10:31-4.

Sirilun S, Chaiyasut C, Kesika P, Peerajan S, Sivamaruthi BS. Screening of lactic acid bacteria with immune modulating property, and the production of lactic acid bacteria mediated fermented soymilk. Natl J Physiol Pharm Pharmacol 2017;7:1397-405.

Chaiyasut C, Woraharn S, Sivamaruthi BS, Kesika P, Lailerd N, Peerajan S. Lactobacillus fermentum HP3 mediated fermented Hericium erinaceus juice as a health promoting food supplement to manage diabetes mellitus. J Evid Based Integr Med 2018;23:1-9.

Sivamaruthi BS. A comprehensive review on clinical outcome of probiotic and synbiotic therapy for inflammatory bowel diseases. Asian Pac J Trop Biomed 2018; 8:179-86.

Reuter G. The Lactobacillus and Bifidobacterium microflora of the human intestine: composition and succession. Curr Issues Intest Microbiol 2001;2:43-53.

Woraharn S, Lailerd N, Sivamaruthi BS, Wangcharoen W, Sirisattha S, Chaiyasut C. 2014. Screening and kinetics of glutaminase and glutamate decarboxylase producing lactic acid bacteria from fermented Thai foods. Food Sci Technol Campinas2014;34:793-9.

Park S, Lee J, Lim S. The probiotic characteristics and GABA production of Lactobacillus plantarum K154 isolated from kimchi. Food Sci Biotechnol 2014;23:1951-7.

Wang Y, Sun Y, Zhang X, Zhang Z, Song J, Gui M, et al. Bacteriocin-producing probiotics enhance the safety and functionality of sturgeon sausage. Food Control 2015;50:729-35.

Woraharn S, Lailerd N, Sivamaruthi BS, Wangcharoen W, Peerajan S, Sirisattha S, et al. Development of fermented Hericium erinaceus juice with high content of L-glutamine and L-glutamic acid. Int J Food Sci Technol 2015;50:2104-12.

Bharti V, Mehta A, Singh S, Jain N, Ahirwal L, Mehta S. Bacteriocin: A novel approach for preservation of food. Int J Pharm Pharm Sci 2015;7:20-9.

Mohanty D, Saini MR, Mohapatra S. In vitro study on release of bioactive antimicrobial compounds from dairy products by certain promising probiotic Lactobacillus strains. Int J Pharm Pharm Sci 2017;9:27-31.

Varankovich NV, Nickerson MT, Korber DR. Probiotic-based strategies for therapeutic and prophylactic use against multiple gastrointestinal diseases. Front Microbiol 2015;6:685. DOI:10.3389/fmicb.2015.00685.

Jin K. Modern biological theories of aging. Aging Dis 2010;1:72-4.

Davidovic M, Sevo G, Svorcan P, Milosevic DP, Despotovic N, Erceg P. Old age as a privilege of the "selfish ones". Aging Dis 2010;1:139-46.

van Heemst D. Insulin, IGF-1 and longevity. Aging Dis 2010;1:147-57.

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Nature 1997;390:45-51.

Takahashi Y, Kuro-o M, Ishikawa F. Aging mechanisms. Proc Natl Acad Sci USA 2000;97:12407-8.

Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013;153:1194-217.

Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med 2009;361:1475-85.

Lopez-Otin C, Galluzzi L, Freije JMP, Madeo F, Kroemer G. Metabolic control of longevity. Cell 2016;166:802-21.

Blackburn EH, Greider CW, Szostak JW. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med 2006;12:1133-8.

Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, et al. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun2014;2:4172.DOI: 10.1038/ncomms5172.

Garcia-Calzon S, Zalba G, Ruiz-Canela M, Shivappa N, Hebert JR, Martinez JA, et al. Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y. Am J Clin Nutr 2015;102:897-904.

Schrager MA, Metter EJ, Simonsick E, Ble A, Bandinelli S, Lauretani F, et al. Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol 2007;102:919-25.

Faria A, Persaud SJ. Cardiac oxidative stress in diabetes: mechanisms and therapeutic potential. Pharmacol Ther 2017;172:50-62.

Wang Y, Hekimi S. Mitochondrial dysfunction and longevity in animals: untangling the knot. Science 2015;350:1204-7.

DiMauro S, Schon EA, Carelli V, Hirano M. The clinical maze of mitochondrial neurology. Nat Rev Neurol 2013;9:429-44.

Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab 2015;21:443-54.

Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, et al. The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity. Aging Cell 2015;14:921-3.

Sala AJ, Bott LC, Morimoto RI. Shaping proteostasis at the cellular, tissue, and organismal level. J Cell Biol 2017;216:1231-41.

Koga H, Kaushik S, Cuervo AM. 2011. Protein homeostasis and aging: the importance of exquisite quality control. Ageing Res Rev 2011;10:205-15.

Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem 2009;78:959-91.

Rubinsztein DC, Marino G, Kroemer G. Autophagy and aging. Cell 2011;146:682-95.

Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, et al. Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities. Am J Pathol 2012;180:963-72.

Claesson MJ, Cusack S, O’Sullivan O, Greene-Diniz R, de Weerd H, Flannery E, et al. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci USA 2011;108 (Suppl.1):4586-91.

Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 2012;488:178-84.

Odamaki T, Kato K, Sugahara H, Hashikura N, Takahashi S, Xiao JZ, et al. Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study. BMC Microbiol 2016;16:90. DOI: 10.1186/s12866-016-0708-5.

Salazar N, Arboleya S, Valdes L, Stanton C, Ross P, Ruiz L, et al. The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations. Front Genet 2014;5:406. DOI:10.3389/fgene.2014.00406.

Salazar N, Valdes-Varela L, Gonzalez S, Gueimonde M, de Los Reyes-Gavilan CG. Nutrition and the gut microbiome in the elderly. Gut Microbes 2017;8:82-97.

Salazar N, Lopez P, Valdes L, Margolles A, Suarez A, Patterson AM, et al. Microbial targets for the development of functional foods accordingly with nutritional and immune parameters altered in the elderly. J Am Coll Nutr 2013;32:399-406.

Tiihonen K, Ouwehand AC, Rautonen N. Human intestinal microbiota and healthy ageing. Ageing Res Rev 2010;9:107-16.

Woodmansey EJ. Intestinal bacteria and ageing. J Appl Microbiol 2007;102:1178-86.

Makivuokko H, Tiihonen K, Tynkkynen S, Paulin L, Rautonen N. The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition. Br J Nutr 2010;103:227-34.

Rampelli S, Candela M, Turroni S, Biagi E, Collino S, Franceschi C, et al. Functional metagenomic profiling of intestinal microbiome in extreme ageing. Aging 2013;5:902-12.

Ursell LK, Haiser HJ, Van TreurenW, Garg N, Reddivari L, Vanamala J, et al. The intestinal metabolome: An intersection between microbiota and host. Gastroenterology 2014;146:1470-6.

Rios-Covian D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilan CG, Salazar N. Intestinal short chain fatty acids and their link with diet and human health. Front Microbiol 2016;7:185. DOI:10.3389/fmicb.2016.00185.

Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, et al. Host-gut microbiota metabolic interactions. Science 2012;336:1262-7.

Jackson MA, Jeffery IB, Beaumont M, Bell JT, Clark AG, Ley RE, et al. Signatures of early frailty in the gut microbiota. Genome Med 2016;8:8. DOI:10.1186/ s13073-016-0262-7.

O’Toole PW, Jeffery IB. Gut microbiota and aging. Science 2015;350:1214-5.

Mueller S, Saunier K, Hanisch C, Norin E, Alm L, Midtvedt T, et al. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol 2006;72:1027-33.

Nagpal R,Mainali R, Ahmadi S, Wang S, Singh R, Kavanagh K, et al. Gut microbiome and aging: Physiological and mechanistic insights. Nutr Health Aging 2018; 4:267-85.

Zhao Y, Zhao L, Zheng X, Fu T, Guo H, Ren F. Lactobacillus salivarius strain FDB89 induced longevity in Caenorhabditis elegans by dietary restriction. J Microbiol 2013;51:183-8.

Park MR, Oh S, Son SJ, Park DJ, Oh S, Kim SH, et al. Bacillus licheniformis isolated from traditional Korean food resources enhances the longevity of Caenorhabditis elegans through Serotonin Signaling. J Agric Food Chem 2015;63:10227-33.

Nakagawa H, Shiozaki T, Kobatake E, Hosoya T, Moriya T, Sakai F, et al. Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans. Aging Cell 2016;15:227-36.

Kimoto-Nira H, Suzuki C, Kobayashi M, Sasaki K, Kurisaki J, Mizumachi K. Anti-ageing effect of a Lactococcal strain: Analysis using senescence-accelerated mice. Br J Nutr 2007;98:1178-86.

Sugimura T, Jounai K, Ohshio K, Suzuki H, Kirisako T, Sugihara Y, et al. Long-term administration of pDC-stimulative Lactococcus lactis strain decelerates senescence and prolongs the lifespan of mice. Int Immunopharmacol 2018;58:166-72.

Tsuji R, Komano Y, Ohshio K, Ishii N, Kanauchi O. Long-term administration of pDCstimulative lactic acid bacteria, Lactococcus lactis strain Plasma, prevents immune-senescence and decelerates individual senescence. Exp Gerontol 2018;111:10-6.

Lee DE, Huh CS, Ra J, Choi ID, Jeong JW, Kim SH, et al. Clinical evidence of effects of Lactobacillus plantarum HY7714 on skin aging: A randomized, double blind, placebo-controlled study. J Microbiol Biotechnol 2015;25:2160-8.

Fatal error: Call to a member function getGalleyLabel() on null in /home/innowar1/public_html/journals/cache/t_compile/%%38^38D^38D7420B%%article.tpl.php on line 182