OVERVIEW ON FLOATING DRUG DELIVERY SYSTEM


Mirmeera Girish Niharika, Kannan Krishnamoorthy, Madhukar Akkala

Abstract


The principal objective behind the writing of this article on the floating drug delivery system (FDDS) was to systematize the recent literature with the core process of floatation in acquiring gastric retention. The different strategies used in the development of FDDS by constructing the effervescent and noneffervescent type of floating tablets basis of which is buoyancy mechanism. FDDS is a method to deliver the drugs that are active locally with a narrow absorption window in the upper gastrointestinal tract, unstable in the lower intestinal environment, and possess low solubility with higher pH values. The novel methodologies in FDDS include approaches to design a single unit and multiple-unit floating systems, the physiological and formulation variability affecting gastric retention along with the use of recently invented and developed polymers. This review also focuses on various in vitro techniques and in vivo studies in view of performance and application of floating systems. Floating dosage forms can be delivered in conventional forms like tablets, capsules with the addition of suitable ingredients along with the gas generating agent. This review also throws light on different techniques used in developing floating dosage forms along with current and novel advancements.


Keywords


Floating drug delivery systems, Gastric retention, Mechanism, Single unit, Multiple units

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About this article

Title

OVERVIEW ON FLOATING DRUG DELIVERY SYSTEM

Keywords

Floating drug delivery systems, Gastric retention, Mechanism, Single unit, Multiple units

DOI

10.22159/ijap.2018v10i6.28274

Date

04-10-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Articles In Press [Scheduled in Nov-Dec 2018] Page: 60-64

Online ISSN

0975-7058

Authors & Affiliations

Mirmeera Girish Niharika
Avanthi Institute of Pharmaceutical Sciences, JNTUH, Hyderabad, Telangana, India
India

Kannan Krishnamoorthy
Department of Pharmacy, Annamalai University, Annamalai nagar, Tamilnadu, India
India

Madhukar Akkala
Avanthi Institute of Pharmaceutical Sciences, JNTUH, Hyderabad, Telangana, India


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