Rasha Khalid Al-dhahir, Myasar Al-kotaji


Objective: The aim of this work was to formulate and evaluate orally disintegrating tablets of cinnarizine that were prepared by direct compression method using different types of diluents and super disintegrants. The rationale behind this work was to accelerate the disintegration of the tablet to provide rapid dissolution, quick action and enhanced bioavailability of the drug.

Methods: The tablets were prepared by direct compression method using different types of diluents as mannitol, microcrystalline cellulose (MCC), and lactose. Different super disintegrants were used such as crospovidone (CP), sodium starch glycolate (SSG) and Kyron T-314; Kyron T-314 was used in different concentrations of 5%, 6%, 7% and 8%. The prepared formulae (F1-F9c) were subjected to flowability studies and post-compression evaluation studies. The optimized formula was selected depending on the time of disintegration and dissolution, then it was subjected to drug-excipient compatibility study and stability study.

Results: Flowability results were ranging from excellent, excellent to good, and good to fair according to the type of the diluent used. All of the prepared tablets showed acceptable hardness, friability, drug content, and disintegration. A rapid disintegration of 11.66±2.25 s with the highest percentage 2 min-drug release of 74.55±3.01% was obtained by using the diluent lactose and the super disintegrant Kyron T-314 (8%) in the formula F9c. The infrared spectroscopic studies of the formula F9c showed no drug-excipient interaction. In addition, the stability study indicated that the optimized formula is a stable formula.

Conclusion: Formula F9c of a rapidly disintegrating tablet was easy to be manufactured and the results showed that this formula had a rapid disintegration, high dissolution profile, no noticeable chemical incompatibility and it was stable upon storage.


Orally disintegrating tablets, Super disintegrants, Cinnarizine, Direct compression


Gryczke A, Schminke S, Maniruzzaman M, Beck J, Douroumis D.Development and evaluation of orally disintegrating tablets ( ODTs ) containing Ibuprofen granules prepared by hot melt extrusion. Colloids Surfaces B Biointerfaces [Internet]. 2011;86:275–84. Available from:

Abdelbary G, Prinderre P, Eouani C, Joachim J, Reynier JP, Piccerelle P. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. Int J Pharm. 2004;278:423–33.

Ph. Eur. European Pharmacopoeia. 9th ed. Council of Europe, Strasbourg; 2017.

Prajapati BG, Patel SN. Formulation, evaluation and optimization of orally disintegrating tablet of cinnarizine. e -Journal Sci Technol. 2010;1:9–21.

Bhowmik D, Chiranjib B, Chandira RM. Fast Dissolving Tablet : An Overview. J Chem Pharm Res [Internet]. 2009;1:163–77. Available from:

Singh S, Shah D. Development and Characterization of Mouth Dissolving Tablet of Zolmitriptan. Asian Pacific J Trop Dis [Internet]. 2012;2(SUPPL.1):S457–64. Available from:

Abdelbary A, Elshafeey AH, Zidan G. Comparative effects of different cellulosic-based directly compressed orodispersable tablets on oral bioavailability of famotidine. Carbohydr Polym [Internet]. 2009;77:799–806. Available from:

Tripathi K. Essentials of Medical Pharmacology [Internet]. 2013. Available from:

Martindale W. Martindale the Extra PharmacopoeiaHardcover. 31st editi. Rittenhouse Book Distributors; 1996.

Bergström C a S, Fagerberg J, Tsinman O, Tsinman K, Avdeef A. Dissolution Rate and Apparent Solubility of Poorly Soluble Compounds in Biorelevant Fluids. Mol Pharm. 2010;5:1801.

USP 33-NF 28. United States Pharmacopeial Convention. Rockville MD, USA; 2010.

Traina K, Cloots R, Bontempi S, Lumay G, Vandewalle N, Boschini F. Flow abilities of powders and granular materials evidenced from dynamical tap density measurement. Powder Technol [Internet]. 2013;235:842–52. Available from:

Shivakumar HN, Kumar MR. Formulation of fast dissolving tablets of doxazocin mesylate drug by direct compression method. Int J Appl Pharm. 2017;9:22–28.

Nagar P, Singh K, Chauhan I, Verma M, Yasir M, Khan A, et al. Orally disintegrating tablets: formulation, preparation techniques and evaluation. J Appl Pharm Sci. 2011;01:35–45.

Patel BP, Patel JK, Rajput GC, Thakor RS. Formulation and Evaluation of Mouth Dissolving Tablets of Cinnarizine. Indian J Pharm Sci. 2010;72:522–5.

Santosh Kumar R, Naga Satya Yagnesh T, Goutham Kumar Gitam V. Optimisation of ibuprofen fast dissolving tablets employing starch xanthate using 23 factorial design. Int J Appl Pharm. 2017;9:51–9.

Tambawala TS, Shah PJ, Shah SA. Orally Disintegrating Tablets of Cinnarizine and Domperidone : A New Arsenal for the Management of Motion Sickness. J Pharm Sci Tech Mgmt. 2015;1:81–97.

Shaikh RH, Jamadar MJ, Patil AD, Tamboli SM. Formulation and In-Vitro Evaluation of Antiemetic Orodispersible Combination Tablets of Domperidone and Cinnerizine by using various Superdisintegrants. Pharmatutor. 2015;3:49–59.

Bajaj S, Singla D, Sakhuja N. Stability Testing of Pharmaceutical Products. J Appl Pharm Sci. 2012;02:129–38.

Rowe RC, editor. Handbook of pharmaceutical excipients. 6. ed. London: APhA, (PhP) Pharmaceutical Press; 2009.

Thoorens G, Krier F, Leclercq B, Carlin B, Evrard B. Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review. Int J Pharm. 2014;473:64–72.

Jivraj M, Martini LG, Thomson CM, Thomson CM. An Overview of The Different Excipients Useful for The Direct Compression of Tablets. Pstt. 2000;3:58–63.

Yassin S, Goodwin DJ, Anderson A, Sibik J, Wilson DI, Gladden LF, et al. The Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1: Influence of Temperature, Porosity and Superdisintegrants. J Pharm Sci. 2015;104:3440–50.

Ferrari F, Bertoni M, Bonferoni MC, Rossi S, Caramella C, Nyström C. Investigation on bonding and disintegration properties of pharmaceutical materials. Int J Pharm. 1996;136:71–9.

Battu SK, Repka MA, Majumdar S, Madhusudan RY. Formulation and evaluation of rapidly disintegrating fenoverine tablets: Effect of superdisintegrants. Drug Dev Ind Pharm. 2007;33:1225–32.

Bele MH, Derle DV. Mechanism of Disintegrant Action of Polacrilin Potassium: Swelling or Wicking? Acta Pharm Sin B [Internet]. 2012;2:70–6. Available from:

Setty CM, Prasad DVK, Gupta VRM, Sa B. Development of fast dispersible aceclofenac tablets: effect of functionality of superdisintegrants. Indian J Pharm Sci [Internet]. 2008;70:180–5. Available from:

Swatantra S, Shweta S, Anil S. Comparative Study on the Effect of Various Superdisintegrants in the Formulation of Ibuprofen Fast Dissolving Tablets. Int J Pharma Res Rev. 2014;3:26–33.

Lakshmi PK, Narendra Y, Rewanthwar SL, Neeharika V. Comperative evaluation of natural and synthetic superdisintegrants in the formulation of fast dissolving tablets. Turk J Pharm Sci. 2013;10:351–66.

Gohel MC. A Review of Co-processed Directly Compressible Excipient. J Pharm Pharm Sci. 2005;8:76–93.

BP. British Pharmacopoeia. London, Stationary office; 2017.

Abd-El Bary A, Louis D, Sayed S. Olmesartan medoxomil surface solid dispersion-based orodispersible tablets: Formulation and in vitro characterization. J Drug Deliv Sci Technol. 2014;24:665–72.

Gattu J, Lakshmi P. Comparative evaluation of natural and synthetic superdisintegrants with newer superdisintegrant Kyron T-314. Acta Pharm Sci. 2011;53:35–44.

Listiohadi Y, Hourigan JA, Sleigh RW, Steele RJ. Moisture sorption, compressibility and caking of lactose polymorphs. Int J Pharm. 2008;359:123–34.

Fatal error: Call to a member function getGalleyLabel() on null in /home/innowar1/public_html/journals/cache/t_compile/%%38^38D^38D7420B%%article.tpl.php on line 182