TRANSDERMAL OF ATENOLOL VIA MICROEMULSIONS

AHMAD AJWAD TALHOUNI; JAMAL ALYOUSSEF ALKRAD; MANAF MOHAMMED AL-DABBAGH; HUSAM ABAZID; SAMER HASAN HUSSEIN-AL-ALI

doi:10.22159/ijap.2019v11i2.30089

Authors

AHMAD AJWAD TALHOUNI Faculty of Pharmacy, Isra University, PO Box 22 and 23, Amman, Jordan,
JAMAL ALYOUSSEF ALKRAD Faculty of Pharmacy, Isra University, PO Box 22 and 23, Amman, Jordan,
MANAF MOHAMMED AL-DABBAGH Faculty of Pharmacy, Isra University, PO Box 22 and 23, Amman, Jordan
HUSAM ABAZID Faculty of Pharmacy, Applied Science Private University, Amman, Jordan
SAMER HASAN HUSSEIN-AL-ALI

DOI:

https://doi.org/10.22159/ijap.2019v11i2.30089

Keywords:

Atenolol, Transdermal, Microemulsions

Abstract

Objective: Developing novel non-ionic microemulsions (MEs) for transdermal of atenolol as satisfactory alternative drug delivery systems for the oral route.

Methods: Seven MEs were developed then checked for encapsulation of atenolol using Fourier Transform Infrared Spectroscopy (FTIR-spectroscopy) (), isotropy, droplet sizes, rheological properties and transdermal flux using Franz diffusion cell. Furthermore, two MEs with best flux values were selected for bioavailability evaluation after transdermal application over rat’s skin.

Results: The results showed that the MEs complies with colloidal systems properties. Also, the developed MEs were stable throughout the study, ideal viscous systems with droplet sizes below 500 nm and isotropic. Besides, FTIR-spectra could reveal the structure of the MEs and encapsulation of atenolol inside the dispersed phase. Moreover, the flux values of atenolol in MEs through rat’s skin varied with different factors such as atenolol concentration, MEs’s composition, and zetapotential. The highest flux value of the developed systems was 243.5±16.3 µg. cm^-2. h^-1. Furthermore, the in vivo results showed that using the two tested microemulsions maximum plasma levels of atenolol 5.22±0.43 and 4.06±0.15 mg. ml^-1at 8.18 and 3.64 h respectively could be achieved.

Conclusion: The developed microemulsions can be promise formulations for transdermal administration of atenolol as alternative for oral tablets.

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Author Biography

JAMAL ALYOUSSEF ALKRAD, Faculty of Pharmacy, Isra University, PO Box 22 and 23, Amman, Jordan,

pharmacy

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