• Sreenivas Patro Sisinthy School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Malaysia
  • Shubbaneswarei Selladurai School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Malaysia


Objective: The objective of this research was to formulate cinnarizine tablets using the liquid-solid compact technique to enhance its solubility and dissolution rate.

Methods: Cinnarizine liquid-solid compacts were formulated using propylene glycol as the non-volatile solvent, Neusilin US2 as the carrier material, Aerosil 200 as the coating material and croscarmellose sodium as the disintegrant. The interaction between drug and excipients were characterized by Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies. Different batches of liquid, solid compacts were prepared by using varying carrier-coating excipient ratio and different concentration of liquid medication. Flow parameters such as bulk density, tapped density, Carr’s Index, Hausner’s Ratio as well as an angle of repose were used to test the flowability of the powder blend. The liquid-solid compacts were produced by direct compression method and were evaluated for tests such as weight variation, drug content, hardness, thickness, friability, wetting time, disintegration time as well as the in vitro dissolution studies.

Results: The results of the preformulation studies of liquisolid compacts showed acceptable flow properties. The results of FTIR and DSC studies showed that there is no drug-excipient interactions. The different R values and concentrations were found to have a marked effect on the dissolution profile. Formulations with higher carrier: coating ratio (R-value) and lower drug concentrations displayed a better dissolution profile. The percentage of drug release of F3 with an R-value of 20 and a drug concentration of 10% was found to be 88.11% when compared to the conventional marketed tablet which released only 44.07% at the end of 2 h.

Conclusion: From this research, it is inferred that liquid-solid technique is a promising and effective approach that can be used to enhance the dissolution rate of cinnarizine.

Keywords: Cinnarizine, Liquid-solid compact, Solubility


1. Raghuvanshi S, Pathak K. Recent advances in delivery systems and therapeutics of cinnarizine: a poorly water-soluble drug with absorption window in the stomach. J Drug Delivery 2014;1-15.
2. Savjani KT, Gajjar AK, Savjani JK. Drug solubility: importance and enhancement techniques. ISRN Pharm 2012;1-10.
3. Spireas S, Bolton M. Liquisolid systems and methods of preparing same, U. S. Patent 5, 968, 550; 1999.
4. Sanjayamitra PVSS, Ganesh GNK. Dissolution and solubility enhancement strategies: current and novel prospectives. J Crit Rev 2018;5:1-10.
5. Jain H, Pasha TY, Bais CS, Bhandari A. Formulation and characterization of liquisolid tablets of valsartan for improvement of dissolution rate. Asian J Pharm Clin Res 2014;7:21-6.
6. Sisinthy SP, Sarah CYL, Nalamolu KR. Optimization of coconut oil based self-micro emulsifying drug delivery systems of olmesartan medoxomil by simplex centroid design. Int J Appl Pharm 2016;8:47-52.
7. Prajapati ST, Bulchandani HH, Patel DM, Dumaniya SK, Patel CN. Formulation and evaluation of liquisolid compacts for olmesartan medoxomil. J Drug Delivery 2013;1-9.
8. Karmarkar AB, Gonjari ID, Hosmani AH, Dhabale PN, Bhise SB. Liquisolid tablets: a novel approach for drug delivery. Int J Health Res 2009;2:45-50.
9. Khan A, Agrawal S. Formulation and evaluation of lumefantrine capsule prepared by using liquisolid technique. Int J Curr Pharm Res 2018;10:43-50.
10. Dalvi PB, Ingale PR. Liquisolid technique: an approach for enhancement of solubility. World J Pharm Pharm Sci 2014;3:434-46.
11. Anil A, Thomas L, Sudheer P. Liquisolid compacts: an innovative approach for dissolution enhancement. Int J Pharm Pharm Sci 2018;10:1-7.
12. Hussain MA, Gorre M, Rao TR, Anjum M. Preparation and evaluation of nilvadipne liquisolid compacts. Int J Pharm Pharm Sci 2014;6:1-8.
13. Jassim ZE. Formulation and evaluation of furosemide liquisolid compact. Int J Appl Pharm 2017;9:39-48.
14. Naveen C, Narra N, Rao TR. Preparation and characterization of liquidsolid compacts for improved dissolution of telmisartan. J Drug Delivery 2014;1-10.
15. Uddin MS, Mamun AA, Tasnu T, Asaduzzaman M. In-process and finished products quality control tests for pharmaceutical tablets according to pharmacopoeias. J Chem Pharm Res 2015;7:180-5.
16. Rajab NA. Preparation and in vitro evaluation of lacidipine oral liquid solid tablet as an approach of solubility and dissolution rate enhancement. Int J Appl Pharm 2018;10:145-53.
17. Haritha B. A review on an evaluation of tablets. J Formulation Sci Bioavailability 2017;1:1-5.
18. Kapoor D, Lad C, Vyas R, Patel M. Formulation development, optimization and in vitro characterization of liquisolid compacts of an oxicam derivative. J Drug Delivery Ther 2016;6:64-70.
19. Paus R, Hart E, Ji Y, Sadowski G. Solubility and caloric properties of cinnarizine. J Chem Eng Data 2015;60:2256-61.
20. Patil DM, Wagh KR, Chaudhari SS, Bairagi VA, Patil VR. Formulation development and evaluation of orodispersible tablet of cinnarizine solid dispersion. Indo Am J Pharm Sci 2017;4:910-25.
21. Dias RJ, Mali KK, Ghorpade VS, Havaldar VD, Mohite VR. Formulation and evaluation of carbamazepine liquisolid compacts using novel carriers. Indian J Pharm Edu Res 2017;51(2S):69-77.
22. Patel BB, Shah CN. Recent research on liquisolid technology for solubility enhancement-a review. Int J Adv Pharm 2016;5:1-7.
23. Gubbi SR, Jarag R. Formulation and characterization of atorvastatin calcium liquisolid compacts. Asian J Pharm Health Sci 2010;5:50-60.
24. Akbari J, Saeedi M, Semnani KM, Ghadi ZS, Hosseini SS. Improving the dissolution properties of spironolactone using a liquisolid technique. Pharm Biomed Res 2015;1:59-70.
25. Javadzadeh Y, Siahi MR, Asnaashari S, Nokhodchi A. An investigation of physicochemical properties of piroxicam liquisolid compacts. Pharm Dev Technol 2007;12:337-43.
26. Kamble PR, Shaikh KS, Chaudhari PD. Application of liquisolid technology for enhancing solubility and dissolution of rosuvastatin. Adv Pharm Bull 2014;4:197-204.
27. Balaji A, Umashankar MS, Kavitha B. Liquisolid technology-a latest review. Int J Appl Pharm 2014;6:11-9.
28. Gavali SM, Pachrane SS, Sankpal SV, Jadhav KR, Kadam VJ. Liquisolid compact: a new technique for enhancement of drug dissolution. Int J Res Pharm Chem 2011;1:705-13.
29. Nokhodchi A, Javadsadeh Y, SIahi Shadbad MR, Barzegar Jalali M. The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts. J Pharm Pharm Sci 2005;8:18-25.
30. Burra S, Yamsani M, Vobalaboina V. The liquisolid technique: an overview. Braz J Pharm Sci 2011;47:475-82.
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How to Cite
Sisinthy, S., & Selladurai, S. (2019). CINNARIZINE LIQUID SOLID COMPACTS: PREPARATION EVALUATION. International Journal of Applied Pharmaceutics, 11(1), 150-157.
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