PENTOXIFYLLINE IN ACUTE ISCHEMIC STROKE PATIENTS WITH BLOOD HYPERVISCOSITY

  • Al Rasyid Department of Neurology, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia,
  • Salim Harris Department of Neurology, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia,
  • Eny Nurhayat Department of Neurology, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia,
  • Joedo Prihartono Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat 10430, Indonesia.

Abstract

Objective: This study evaluated the efficacy of pentoxifylline, a hemorrheologic agent, for treating acute ischemic stroke in patients with blood
hyperviscosity.
Methods: Patients were randomly allocated within 3 days of stroke onset to study or control treatment. All the patients received the standard acute
ischemic stroke treatment. The study treatment was intravenous pentoxifylline 1200 mg/day for 5 consecutive days and oral pentoxifylline 800 mg
in two divided doses for 23 days. Blood viscosity was evaluated on days 7 and 30. The outcomes were assessed by the National Institutes of Health
Stroke Scale (NIHSS), modified Rankin Scale, and Barthel index (BI) criteria.
Results: The median baseline viscosity was 6.89 poise in the study and 6.46 poise in the control groups and had decreased in all the patients on
days 7 and 30. The decrease in the study group on day 7 (1.13 poise) was greater than that in the control group (0.57 poise); the difference was not
significant. The NIHSS score improved by 32% in the study group (relative risk [RR]=1.00, 95% confidence interval [CI]: 0.421–3.556; p=1.00). At
1-month, 67% of the study group had a good functional outcome (RR=1.026, 95% CI: 0.656–1.605; p=0.909).
Conclusion: Pentoxifylline decreased blood viscosity and improved clinical outcome in this patient series.

Keywords: Blood hyperviscosity, Digital microcapillary, Ischemic stroke, Pentoxifylline.

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How to Cite
Rasyid, A., Harris, S., Nurhayat, E., & Prihartono, J. (2018). PENTOXIFYLLINE IN ACUTE ISCHEMIC STROKE PATIENTS WITH BLOOD HYPERVISCOSITY. International Journal of Applied Pharmaceutics, 10(1), 307-310. https://doi.org/10.22159/ijap.2018.v10s1.68
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