CHARACTERIZATION AND HYPOGLYCEMIC STUDY OF ISOLATED NATURAL POLYMER FROM THE STEM OF MANILKARA HEXANDRA (ROXB.) DUBARD

  • IRUDAYA MONISHA S. PG and Research Department of Chemistry, Holy Cross College (Autonomous), Trichy, Tamil Nadu, India
  • ROSALINE VIMALA J. PG and Research Department of Chemistry, Holy Cross College (Autonomous), Trichy, Tamil Nadu, India

Abstract

Objective: In the present study, the isolated natural polymer from the stem of Manilkara hexandra and their physiochemical parameters were investigated. It is further involved in hypoglycemic studies.


Methods: The gum exudates were screened for phytochemicals, physicochemically analyzed for solubility, pH, total ash, moisture content, acid insoluble ash, water soluble ash, sulfated ash, flow property, and it is characterized by Fourier Transform Infrared analysis (FT-IR), Scanning Electron Microscope (SEM), X-ray diffraction analysis (XRD), Nuclear Magnetic Resonance (NMR) studies (13Carbon and 1Proton) and it was examined in vitro studies by hypoglycaemic activity.


Results: The isolated gum extracted from the stem of Manilkara hexandra (Roxb.) Dubard ash values were found to be low. The gum is found to be hygroscopic in nature due to its high moisture content (0.9131±0.03). Fourier Transform Infrared (FT-IR) spectra show relevant functional groups for gum, which is further confirmed by resonance spectral studies. The X-ray diffraction (XRD) pattern shows that the gum is amorphous as well as crystalline in nature. Scanning Electron Microscope (SEM) image confirms that the gum particles have irregular size and shape. Sugar composition analysis by Thin Layer Chromatography indicated the presence of rhamnose, arabinose. The in vitro study of hypoglycemic activity shows the best report compared with the standard. The experimental evidence offers scope to use this natural polymer in the food and pharmaceutical industry.


Conclusion: The isolated natural polymer shows good result in hypoglycemic studies compared with standard.

Keywords: Manilkara hexandra, Isolated polymer, Characterization, Hypoglycemic activity

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MONISHA S., I., & VIMALA J., R. (2019). CHARACTERIZATION AND HYPOGLYCEMIC STUDY OF ISOLATED NATURAL POLYMER FROM THE STEM OF MANILKARA HEXANDRA (ROXB.) DUBARD. International Journal of Applied Pharmaceutics, 11(4), 206-213. https://doi.org/10.22159/ijap.2019v11i4.32988
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