ADVERSE REACTIONS TO FIRST-LINE ANTI-TUBERCULOSIS DRUGS AS A RISK FACTOR OF PULMONARY TUBERCULOSIS TREATMENT DEFAULT IN JAKARTA, INDONESIA

  • STEFANUS IMANUEL SETIAWAN Faculty of Medicine Universitas Indonesia, Jakarta
  • PURWANTYASTUTI ASCOBAT Department of Pharmacology and Therapeutic, Faculty of Medicine Universitas Indonesia, Jakarta

Abstract

Objective: Tuberculosis (TB) is one of the leading fatal infectious diseases and remains a major health problem worldwide. Moreover, adverse effects of TB treatment can escalate treatment default. This study aimed to evaluate the correlation between adverse reactions to anti-TB drugs and treatment default.


Methods: We performed a cross-sectional study using medical record data of a total 172 adult patients with pulmonary TB who were treated with first-line anti-TB drugs at Dr. Cipto Mangunkusumo National General Hospital in Jakarta, Indonesia during 2014 and who experienced adverse reactions.


Results: Of the total, 127 patients (73.8%) had minor adverse reactions and 45 patients (26.2%) experienced major adverse reactions. Predominant adverse reactions included gastrointestinal disorders (34%) and drug-induced hepatitis (60%). There was a significant correlation between adverse reactions to anti-TB drugs and treatment default cases (odds ratio (OR), 9.33; 95% confidence interval (CI), 4.20–20.72; p<0.001). The results of multivariate analysis showed that TB treatment outcome is affected by adverse drug reactions (OR, 10.91; 95% CI, 4.62–25.75; p<0.001), drug use in treating concomitant diseases (OR, 3.03; 95% CI, 1.30–7.05; p=0.010), and type of anti-TB drug used (OR, 2.41; 95% CI, 0.99–5.83; p=0.045).


Conclusion: Based on these results, we showed that adverse reactions to anti-TB drugs can affect TB treatment outcome and can serve as a risk factor to treatment default.

Keywords: Adverse reaction, Anti-tuberculosis drug, Treatment default, Pulmonary tuberculosis

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SETIAWAN, S. I., & ASCOBAT, P. (2019). ADVERSE REACTIONS TO FIRST-LINE ANTI-TUBERCULOSIS DRUGS AS A RISK FACTOR OF PULMONARY TUBERCULOSIS TREATMENT DEFAULT IN JAKARTA, INDONESIA. International Journal of Applied Pharmaceutics, 11(6), 80-83. https://doi.org/10.22159/ijap.2019.v11s6.33551
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