Formulation and evaluation of amoxicillin trihydrate, metronidazole and famotidine loaded mucoadhesive gastroretentive films
Objective: Mucoadhesive gastroretentive films of amoxicillin trihydrate, metronidazole andfamotidine were formulated by using polymers and plasticizer to combat the H. pyloribacteria.
Methods: The mucoadhesive gastroretentive films bearing amoxicillin trihydrate, metronidazoleand famotidine were prepared using solvent casting method. Various formulation variables which affects the gastroretentive films preparation and its characterization were optimized. The optimized gastroretentive films were characterized for various attributions viz. drug content uniformity, in vitrodrug release, FTIR spectroscopy, DSC, SEM and ex-vivodrug permeation studies across the mucous membrane. The in-vitrogrowth inhibition study and in-vivobacterial clearance study of mucoadhesive gastro retentive films were studied to evaluate their effectiveness in eradicating H. pylori.
Results: Bioadhesive property of films increased with increasing the chitosan concentration andconcentration of PAA (Polyacrylic Acid). CH-PAA IPC (Chitosan-Polyacrylic Acid Interpolymer Complex) films exhibited greater bioadhesion. FTIR spectra indicated that there was no interaction between the polymers and drugs used. Drugs content was found to be in the range and there was no significant change in the surface morphology of the films while upon storage. Drugs loaded CH-PAA IPC film formulation provided 2 times and 3 times greater anti – H. pylori activity than CH film formulation and plain drugs solution, respectively due to theirbioadhesive nature and increased residence time in the stomach.
Conclusion: The developed system was well taken up and processed by the cells of gastricmucosa of stomach. This shows that the system could attach the mucosal gel layer where H.pylorireside.
This work is licensed under a Creative Commons Attribution 4.0 International License.