• O. SREEKANTH REDDY Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu 515003, India
  • M. C. S. SUBHA Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu 515003, India
  • T. JITHENDRA Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu 515003, India
  • C. MADHAVI Department of Polymer Science and Technology, Sri Krishnadevaraya University, Ananthapuramu 515003, India
  • K. CHOWDOJI RAO Department of Polymer Science and Technology, Sri Krishnadevaraya University, Ananthapuramu 515003, India
  • B. MALLIKARJUNA Department of Chemistry, Government College (A), AKN University, Rajahmundry, India


Objective: The aim of the present study was to fabricate and evaluate the drug release studies using Sodium Alginate (SA) and Gelatin (GE) microbeads intercalated with Kaolin (KA) nanoclay for sustained release of D-Penicillamine (D-PA).

Methods: Sodium alginate/gelatin/Kaolin blend microbeads were prepared by an extrusion method by using glutaraldehyde (GA) as a crosslinker. The obtained microbeads were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and X–ray diffraction (XRD). Drug release kinetics of the microbeads was investigated in simulated intestinal fluid (pH 7.4) at 37 °C.

Results: Microbeads formation was confirmed by FTIR spectroscopy. X-RD reveals that the KA should be intercalated with the drug and also it confirms the molecular level dispersion of D-Penicillamine into microbeads. Scanning Electron Microscopy (SEM) studies reveal that the beads were in spherical shape with some wrinkled depressions on the surface. The in vitro release study indicates the D-Penicillamine released in a controlled manner. The in vitro release kinetics was assessed by Korsmeyer-Peppas equation and the ‘n’ value lies in between 0.557-0.693 indicates Non-Fickian diffusion process.

Conclusion: The results suggest that the developed KA intercalated microbeads are good potential drug carrier for the controlled release of D-PA.

Keywords: Sodium alginate (SA), Gelatin (GE),, Kaolin (KA), Drug delivery, D-Penicillamine (D-PA)


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