DESIGN AND CHARACTERIZATION OF CANDESARTAN CILEXETIL ORAL NANOEMULSION CONTAINING GARLIC OIL

CANDESARTAN CILEXETIL ORAL NANOEMULSION

  • ABULFADHEL JABER NEAMAH AL-SHAIBANIA Department of Pharmaceutics, Faculty of Pharmacy, University of Kufa, Najaf, Iraq
  • KARRAR MOHAMMED HASAN AL-GBURIB Department of Clinical Pharmacy, Faculty of Pharmacy, University of Kufa, Najaf, Iraq https://orcid.org/0000-0003-1162-5789
  • KARRAR TALIB KHUDHAIR ALBO HAMRAHA Department of Pharmaceutics, Faculty of Pharmacy, University of Kufa.
  • ALI MOHAMMED ABD ALRIDHAB Department of Clinical Pharmacy, Faculty of Pharmacy, University of Kufa, Najaf, Iraq

Abstract

Objective: This study was designed to prepare and characterize oil in water (o/w) nanoemulsion of candesartan cilexetil for oral administration. Preparation of candesartan cilexetil as nanoemulsion could increase its water solubility and thus could enhance its bioavailability.


Methods: Aqueous titration method was used to construct the pseudo-ternary phase diagrams of nanoemulsion (NE) consisting of oil, various weight ratios of surfactant and co-surfactant (S mix), and deionized water. Different characterization techniques were conducted on the prepared nanoemulsions to obtain the optimized formula.


Results: Characterizations of formula NE-4 (consists of 0.16% of candesartan cilexetil, 10% of garlic oil, 35 % of S mix (3:1) and 54.84% of deionized water) revealed the following characteristics: droplet size range (95-139 nm), polydispersity index (0.14), zeta potential value (-41.06 mV) and pH value (6.71), which are suitable for oral administration. Candesartan cilexetil in vitro release from this formula was significantly high (P<0.05) and scanning probe microscopy (SPM) study confirmed that the optimized formula (NE-4) was in nano-scale.


Conclusion: Nanoemulsion formula 4 (NE-4) of candesartan cilexetil is the optimized formula and it could be a promising formula for improving the water solubility of candesartan cilaxetil.

Keywords: Oral Nanoemulsion, Pseudo-ternary phase diagram, Biopharmaceutics classification system (BCS), Candesartan cilexetil, Solubility

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AL-SHAIBANIA, A. J. N., AL-GBURIB, K. M. H., ALBO HAMRAHA, K. T. K., & ABD ALRIDHAB, A. M. (2019). DESIGN AND CHARACTERIZATION OF CANDESARTAN CILEXETIL ORAL NANOEMULSION CONTAINING GARLIC OIL. International Journal of Applied Pharmaceutics, 11(6), 116-124. https://doi.org/10.22159/ijap.2019v11i6.35066
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