THE POTENTIAL OF CACAO (THEOBROMA CACAO L.) POD HUSK EXTRACT ON THE NUMBER OF FIBROBLAST CELLS OF WISTAR RATS WOUND POST-TOOTH EXTRACTION

  • BUDI YUWONO Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jember University, Indonesia
  • SELVIA ELGA Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jember University, Indonesia
  • DWI MERRY C. Department of Oral Pathology, Faculty of Dentistry, Jember University, Indonesia

Abstract

Objective: The aim of this study was to determine the effect of cacao (Theobroma cacao L.) pod husk extract on the number of fibroblast cells in rats’ wound post-tooth extraction.


Methods: A total of 24 rats were divided into 2 groups. Control group and a treatment group. The tooth extraction was performed on a mandibular left first molar. Cacao (Theobroma cacao L.) pod husk extract was applied on the treatment group, and a saline solution was applied on the control group once a day by intragastric administration. On the 3rd, 7th and 10th day, 4 rats’ were sacrificed and the mandibulars were subsequently removed for histological process. The fibroblast cells calculation was performed on the histological preparation using a microscope. The data were analyzed using One Way ANOVA.


Results: More fibroblast cells were observed in the treatment group when compared to the control group. The cacao (Theobroma cacao L.) pod husk extract administration for 10 d induced more fibroblast cell quantity compared to that for 3 d.


Conclusion: The cacao (Theobroma cacao L.) pod husk extract administration may enhance the fibroblast cell quantity in the rats with post-tooth extraction wounds.

Keywords: Cacao pods husk, Fibroblast, Tooth extraction

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YUWONO, B., ELGA, S., & C., D. M. (2019). THE POTENTIAL OF CACAO (THEOBROMA CACAO L.) POD HUSK EXTRACT ON THE NUMBER OF FIBROBLAST CELLS OF WISTAR RATS WOUND POST-TOOTH EXTRACTION. International Journal of Applied Pharmaceutics, 11(4), 30-32. https://doi.org/10.22159/ijap.2019.v11s4.35285
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