• S. J. SHANKAR Department of Pharmaceutics, Vivekananda College of Pharmacy, Dr. Rajkumar Road, Rajajinagar 2nd Stage, Bengaluru 560055
  • JASWANTH GOWDA B. H. Department of Pharmaceutics, Vivekananda College of Pharmacy, Dr. Rajkumar Road, Rajajinagar 2nd Stage, Bengaluru 560055
  • AKSHATHA R. S. Department of Pharmaceutics, PES College of Pharmacy, PES University, 50 Feet Road, Hanumanthnagar, Bengaluru 560050
  • BASAVARAJ METIKURKI Department of Pharmaceutical Chemistry, Nitte College of Pharmaceutical Sciences, NMIT Campus, Yelahanka, Bengaluru 560064
  • MOHAMED REHAMATHULLA Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Asir Provience, Saudi Arabia, Post Box No–960


Nearly 40% of drugs coming to the market nowadays are having poor solvency related issues and 70% molecules in discovery pipeline are in effect fundamentally insoluble in water. Nanocrystals is an unmistakable instrument to tackle the issue identified with poor fluid solvency and helps in improving the bioavailability of various drugs as presented in the literature. The particle size reduction came about into temperamental nanocrystalline system and the phenomenon of ostawald ripening happens. These techniques are preparing to the improvement of nanosized objects, which can play out multiple technological tasks. There are a few couples of noteworthy benefits of nanocrystal formulations, for example, upgrade oral bioavailability, improved dose proportionality, reduced food effects, appropriateness for administration by all routes and probability of sterile filtration because of diminished particle size range. One of the most adequate preferences of nanocrystals is their wide scope of utilization, for example, ophthalmic delivery, oral delivery, transdermal delivery, pulmonary delivery, intravenous delivery and targeted delivery, especially for tumour and brain. The increment in commercial value of nanocrystals just as the measure of nanocrystal products in the market is picking up more of attention to be utilized as a strategy so as to get commercial advantages. In this paper a brief and accurate precis of nanosuspension is stated with specific spotlight on nanosuspension preparation methodologies, benefits and few major applications of nanosuspensions.

Keywords: Nanocrystal, Nanosuspension, Bioavailability, Solubility, Media milling, Dissolution rate, Bottom up approach, High pressure homogenization


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How to Cite
SHANKAR, S. J., B. H., J. G., R. S., A., METIKURKI, B., & REHAMATHULLA, M. (2019). A A REVIEW ON THE ROLE OF NANOCRYSTALS AND NANOSUSPENSIONS IN DRUG DELIVERY SYSTEMS. International Journal of Applied Pharmaceutics, 12(1), 10-16. https://doi.org/10.22159/ijap.2020v12i1.35508
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