FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF PSEUDOEPHEDRINE HCL
Objective: This study was conducted to design a transdermal dosage form of pseudoephedrine HCL and to evaluate its release under controlled rates for sustained transdermal delivery of Pseudoephedrine.
Methods: Transdermal patches were prepared by the casting evaporation method. Utilizing eudragit RL100. Patches were characterized by physical appearance, moisture content, thickness, weight variation, folding endurance, tensile strength and stability studies. Fourier transform infrared spectroscopic studies (FTIR), differential scanning calorimetry analysis (SCA) and XRD studies. Four different permeation enhancer (Tween 20, thymus oil, castor oil and eucalyptus oil) was employed. In vitro release of drugs was done in the dissolution paddle apparatus. Release studies were performed in distilled water at 37 °C. Scanning electron microscope studies were performed before and after the drug.
Results: Transdermal patches with enhancers were formulated successfully with a concentration of 1% (W/V). The patches indicated stable physicochemical characteristics. FTIR, SCA and XRD Studies showed that there were no physical and chemical interactions between excipients and drugs. Results of in vitro permeation studies showed that enhancers used in this study increased drug released. The enhancers showed faster released than no enhancer. This arrangement can be shown as Tween>Eucalyptus oil>Thymus oil and castor oil. Formulation F2 is optimized among all formulations showed an 83.3% release.
Conclusion: Transdermal patches of pseudoephedrine were successfully developed by using pseudo epinephrine HCL. These patches proved to be very useful for therapeutic purposes in the pharmaceutical industry without making the patients unconscious, unlike the trivial methods of treatment.
2. Yadav V. Transdermal drug delivery system. Int J Pharm Sci Res 2012;3:376-82.
3. Benson HA. Transdermal drug delivery: penetration enhancement techniques. Curr Drug Delivery 2005;2:23-33.
4. Rahman G, Syed UJ, Syed F, Samiullah S. Preliminary phytochemical screening, quantitative analysis of alkaloids, and antioxidant activity of crude plant extracts from ephedra intermedia indigenous to balochistan. Hindawi 2017;1:1-7.
5. Gul R, Jan US, Ahmad M, Akhtar M, Faridullah S. Formulation, characterization, in vitro and ex vivo release of Ephedra extract from topical preparations using dialysis membrane and rabbit skin. Dissolution Technol 2017;24:24–30.
6. Biswajit M, Sushmita M, Ritu G, Balaram P. A comparison between povidoning-ethylcellulose and povidone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation. Eur J Pharm Biopharm 2005;59:475–8.
7. Chandy T, Sharma CP. Prostaglandin E1-immobilized poly (vinyl alcohol)-blended chitosan membranes: Blood compatibility and permeability properties. J Appl Polym Sci 1992;44:2145–56.
8. Wiwat P, Jirapornchai S, Prapaporn B, Thanaporn A, Wirach T, Garnpimol CR, et al. Nicotine transdermal patches using polymeric natural rubber as the matrix controlling system: effect of polymer and plasticizer blends. J Member Sci 2012;411:81–90.
9. Arijit D, Sibaji G, Biplab KD, Sudip D. A novel technique for treating the type-ll diabetes by transdermal patches prepared by using multiple polymer complexes. Int J Pharma Res Dev 2010;9:195–204.
10. Viswanatha RM, Jayashankar RV, Ramesh Y, Venkateswarlu I. Formulation and evaluation of fluconazole transdermal patches. Int J Inst Pharma Life Sci 2011;1:18–29.
11. Sanap GS, Dama GY, Karpe AS, Nalawade SV, Kakadi RS, Jadhav UY, et al. Preparation of transdermal monolithic systems of indapamide by solvent casting method and the use of vegetable oils as permeation enhancer. Int J Green Pharm 2008;2:129–33.
12. Kusum DV, Saisivam S, Maria GR, Depti PU. Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride. Drug Dev Ind Pharm 2003;29:495–503.
13. Anod HV, Gupta NV, Gowda DV, Manohar M. Preparation and evaluation of simvastatin transdermal film. Int J Appl Pharm 2018;10:235-8.
14. Muhammad RA, Mahmood A, Asad A, Rai MS, Asif M. Formulation design and development of matrix diffusion controlled transdermal drug delivery of glimepiride. Drug Design Dev Ther 2018;12:349-64.
15. Yaqoob A, Ahmad M, Mahmood A, Sarfraz RM. Comparative study of polymeric films for sustained transdermal delivery of metoprolol: preparation, in vitro and ex vivo characterization. Lat Am J Pharm 2016;35:2171–9.
16. Mokale VJ, Naik JB, Verma U, Yadava SK. Preparation and characterization of biodegradable limepiride loaded PLA nanoparticles by o/w solvent evaporation method using high-pressure homogenizer a factorial design approach. SAJ Pharm Pharmacol 2014;1:1–10.
17. Gupta R, Mukherjee B. Development and in vitro evaluation of diltiazem hydrochloride transdermal patches based on povidone–ethylcellulose matrices. Drug Dev Ind Pharm 2003;29:1-7.
18. Tanwar YS. Formulation and evaluation of transdermal films of salbutamol sulphate. Dhaka Univ J Pharm Sci 2005;4:93–7.
19. Suryani, Wa OSM, Ruslin, Michrun N, Rima A, Marganita H, et al. Formulation and physical characterization of curcumin nanoparticle transdermal patch. Int J Appl Pharm 2019;11:217-21.
20. Entwistle CA, Rowe RE. Plasticization of cellulose ethers used in the film coating of tablets. J Pharm Pharmacol 1979;31:269 72.
21. Meenakshi B, Rajesh KN, Mahip B. Development and characterization of transdermal patches of Metoprolol tartrate. Asian J Pharm Clin Res 2010;3:130 4.
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