• Divya Jyothi NGSM Institute of Pharmaceutical Sciences, Nitte University


Objective: Current study is aimed at formulation of silver nanoparticles loaded with the extract of Coleus amboinicus leaf extract by microwave irradiation. A facile and green synthesis of silver nanoparticles by using biological agent such as plant extracts with the aid of microwave irradiation is proposed as an economical and environmentally friendly approach alternative to chemical and physical methods.


Methodology: In order to fabricate silver nanoparticles by microwave irradiation, aqueous extract of leaves Coleus amboinicus (CA) were treated with aqueous silver nitrate solution and mixture was placed in microwave oven for exposure to microwave. Optimizations of the process were carried out by varying the quantity of extract, silver nitrate concentration and duration of microwave irradiation. Formations of nanoparticles were confirmed by UV-visible spectroscopy observing for the presence of surface plasmon resonance (SPR) peak. Nanoparticles were characterised by scanning electron microscopy, transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy. 


Results: Silver nanoparticle showed the SPR optical absorption band peak at 434nm by UV-visible spectrophotometer. Reaction mixture containing 2mM silver nitrate and 9 ml of extract subjected to microwave irradiation of 60 sec at a temperature of 600C was found to be optimised condition which produced nanoparticles which were spherical in shape and had an average diameter of 15.685nm.


 Conclusion: This research study opens an innovative design to progress our understanding of how silver nanoparticles behave can be optimized to improve their surface morphology, which is beneficial to improve its therapeutic effect.



Keywords: Key words: Coleus amboinicus, silver nanoparticles, microwave irradiation


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Jyothi, D., SHERIN P CHERIYAN, SHAIKH RAFIYA RAFIK AHMED, SNEH PRIYA, JAINEY P JAMES, & THERESA GEORGE P. (2020). MICROWAVE ASSISTED GREEN SYNTHESIS OF SILVER NANOPARTICLES USING COLEUS AMBOINICUS LEAF EXTRACT . International Journal of Applied Pharmaceutics, 12(3). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/37121
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