MICROWAVE ASSISTED GREEN SYNTHESIS OF SILVER NANOPARTICLES USING COLEUS AMBOINICUS LEAF EXTRACT

  • Divya Jyothi NGSM Institute of Pharmaceutical Sciences, Nitte University
  • SHERIN P CHERIYAN
  • SHAIKH RAFIYA RAFIK AHMED
  • SNEH PRIYA
  • JAINEY P JAMES
  • THERESA GEORGE P

Abstract

Objective: Current study is aimed at formulation of silver nanoparticles loaded with the extract of Coleus amboinicus leaf extract by microwave irradiation. A facile and green synthesis of silver nanoparticles by using biological agent such as plant extracts with the aid of microwave irradiation is proposed as an economical and environmentally friendly approach alternative to chemical and physical methods.


 


Methodology: In order to fabricate silver nanoparticles by microwave irradiation, aqueous extract of leaves Coleus amboinicus (CA) were treated with aqueous silver nitrate solution and mixture was placed in microwave oven for exposure to microwave. Optimizations of the process were carried out by varying the quantity of extract, silver nitrate concentration and duration of microwave irradiation. Formations of nanoparticles were confirmed by UV-visible spectroscopy observing for the presence of surface plasmon resonance (SPR) peak. Nanoparticles were characterised by scanning electron microscopy, transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy. 


 


Results: Silver nanoparticle showed the SPR optical absorption band peak at 434nm by UV-visible spectrophotometer. Reaction mixture containing 2mM silver nitrate and 9 ml of extract subjected to microwave irradiation of 60 sec at a temperature of 600C was found to be optimised condition which produced nanoparticles which were spherical in shape and had an average diameter of 15.685nm.


 


 Conclusion: This research study opens an innovative design to progress our understanding of how silver nanoparticles behave can be optimized to improve their surface morphology, which is beneficial to improve its therapeutic effect.


 


 

Keywords: Key words: Coleus amboinicus, silver nanoparticles, microwave irradiation

References

1. Yuet YL, Buong WC, Mitsuaki N, Son R. Synthesis of silver nanoparticles by using tea leaf extract from Camellia sinensis. Int J Nanomed. 2012;7:4263–7.
2. Iravani S, Korbekandi H, Mirmohammadi SV, Zolfaghari B. Synthesis of silver nanoparticles: chemical, physical and biological methods, Res Pharm Sci 2014;9:385–406.
3. Sreeram KJ, Nidhin M, Nair BU. Microwave assisted template synthesis of silver nanoparticles Bull Mater Sci. 2008; 31(7):937–42.
4. Lukhoba CW, Simmonds MSJ, Paton AJ. Plectranthus: A review of ethnobotanical uses. J Ethnopharmacol.2006;103:1–24.
5. Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus: Botanical, phytochemical, pharmacological and nutritional significance. Molecul. 2016;21:369-71.
6. Jyothi D, Priya S, James JP. Antimicrobial potential of hydrogel incorporated with PLGA nanoparticles of Crossandra infundibuliformis. Int J App Pharm.2019; 11(2):1-5.
7. Patel K, Kapoor S, Dave DP, Mukherjee T. Synthesis of nanosized silver colloids by microwave dielectric heating. J Chem Sci.2005;117(1):53–60.
8. Ahmadi O, Jafarizadeh-Malmiri H, Jodeiri N. Eco-friendly microwave-enhanced green synthesis of silver nanoparticles using Aloe vera leaf extract and their physico-chemical and antibacterial studies. Green Process Synth.2018;7:231–40.
9. Liem LN, Nguyen D. Microwave assisted green synthesis of silver nanoparticles using mulberry leaves extract and silver nitrate solution.Technol.2019;7(7):1-9.
10. Brause R, Moeltgen H, K Kleinermanns. Characterization of laser-ablated and chemically reduced silver colloids in aqueous solution by UV/VIS spectroscopy and STM/SEM microscopy.Appl Phys B.2002;75(6):711–6
11. Birla SS, Gaikwad SC, Gade AK, Rai MK. Rapid Synthesis of silver nanoparticles from Fusarium oxysporum by optimizing physicocultural conditions. Sci World J.2013:18;1-12.
12. Khalila MMH, Ismaila EH, El-Baghdadyc KZ, Mohamed D. Green synthesis of silver nanoparticles using olive leaf extract and its antibacterial activity. Arab J Chem.2014;7: 1131-9.
13. Sosa IO, Noguez C, Barrera RG. Optical properties of metal nanoparticles with arbitrary shapes. J Phys Chem B. 2003;107:6269-75.
14. Song JY, Kim BS. Rapid biological synthesis of silver nanoparticles using plant leaf extracts. Bioprocess Biosyst Eng. 2009; 32(1):79-84.
15. Gurunathan S, Kalishwaralal K, Vaidyanathan R, Deepak V, Pandian SRK, Muniyandi J, et al. Biosynthesis, purification and characterization of silver nanoparticles using Escherichia coli. Colloids Surf B. 2009;74(1):328-35
16. Liu FK, Huang PW, Chu TC, Ko FH. Gold seed-assisted synthesis of silver nanomaterials under microwave heating. Mater Lett. 2005;59:940-4.
17. Kumar P, Selvi SS, Govindaraju M. Seaweed-mediated biosynthesis of silver nanoparticles using Gracilaria corticata for its antifungal activity against Candida species. Appl Nanosci.2013;3:495–500.
18. Sreelakshmy V, Deepa MK, Mridula P. Green synthesis of silver nanoparticles from Glycyrrhiza glabra root extract for the treatment of gastric ulcer. J Develop Drugs.2016; 5(2):152-7
19. Satyavani K, Ramanathan T, Gurudeeban S. Plant mediated synthesis of biomedical silver nanoparticles by using leaf extract of Citrullus colocynthis. Res J Nanosci Nanotechnol 2011; 1:95–101.
Statistics
5 Views | Downloads
How to Cite
Jyothi, D., SHERIN P CHERIYAN, SHAIKH RAFIYA RAFIK AHMED, SNEH PRIYA, JAINEY P JAMES, & THERESA GEORGE P. (2020). MICROWAVE ASSISTED GREEN SYNTHESIS OF SILVER NANOPARTICLES USING COLEUS AMBOINICUS LEAF EXTRACT . International Journal of Applied Pharmaceutics, 12(3). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/37121
Section
Original Article(s)