DISTRIBUTION PATTERNS AND RISK FACTORS OF DYSLIPIDEMIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: A CROSS-SECTIONAL STUDY IN BOGOR, INDONESIA

  • SARASWATI PRADIPTA Magister Program of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta 10440, Indonesia.
  • HERI WIBOWO Magister Program of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta 10440, Indonesia. Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta 10440, Indonesia. 3Department of Internal Medicine
  • DANTE SAKSONO HARBUWONO Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta 10440, Indonesia.
  • EKOWATI RAHAJENG Centre for Research and Development of Public Health, National Institute of Health Research and Development, Ministry of Health, Jakarta 12950, Indonesia.
  • RAHMA AYU LARASATI Magister Program of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta 10440, Indonesia.
  • RONA KARTIKA Magister Program of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta 10440, Indonesia.

Abstract

Objective: Type 2 diabetes mellitus (T2DM) patients tend to have abnormal lipid profiles, explaining the association between elevated cholesterol and
triglyceride levels in diabetic patients and coronary heart disease. This study aims to evaluate how the common risk factors for dyslipidemia affect
the lipid profile of diabetic patients and to determine which factors can be used as predictors for the occurrence of dyslipidemia in T2DM patients.
Methods: A total of 238 diabetic patients (63 male and 175 female; age: 31–70 years) were enrolled in this cross-sectional study. All of them had
undergone regular examinations in cohort studies on risk factors for non-communicable diseases conducted by the Ministry of Health in Bogor
between December 2017 and January 2018.
Results: The result found that age differences did not affect lipid profile levels, and the females had higher mean values of body mass index (p<0.001),
total cholesterol (TC) (p<0.05), and high-density lipoprotein (HDL) (p<0.001) than the males. The most common occurrences of dyslipidemia were
high TC level (57.1%), followed by high low-density lipoprotein (LDL) level (47.1%), high triglyceride level (37.4%), and low HDL level (16.4%). Being
overweight was found to be the best predictor of dyslipidemia.
Conclusion: The results of this study suggest that in T2DM patients, sex affects TC and HDL levels, whereas age does not exert a significant effect on
the lipid profiles. In addition, poor glycemic control, hypertension, and obesity may serve as predictors of dyslipidemia in T2DM patients.

Keywords: Type 2 diabetes, Dyslipidemia, Cardiovascular disease

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PRADIPTA, S., WIBOWO, H., HARBUWONO, D. S., RAHAJENG, E., LARASATI, R. A., & KARTIKA, R. (2020). DISTRIBUTION PATTERNS AND RISK FACTORS OF DYSLIPIDEMIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: A CROSS-SECTIONAL STUDY IN BOGOR, INDONESIA. International Journal of Applied Pharmaceutics, 12(1), 5-8. https://doi.org/10.22159/ijap.2020.v12s1.24045
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