Ravindra C Sutar, V K Kalaichelvan


Holoptelea integrifolia (Roxb.) Planch has been used from long time in traditional medicine. The main objective of the work was to evaluate the antioxidant activity of leaves of Holoptelea integrifolia (Roxb.) Planch. The antioxidant activity of petroleum ether and methanolic extract of Holoptelea integrifolia (HI) leaves was evaluated using Hydroxyl Radical Scavenging Activity and Total Reduction Capability models. Preliminary Phytochemical investigation of the petroleum ether extract (PEHI) of Holoptelea integrifolia leaves reveals the presence of steroids, terpenoids, alkaloids, glycosides, flavonoids, proteins, tannins, and carbohydrate while methanolic extract (MHI) of Holoptelea integrifolia showed the presence of steroids, alkaloids, flavonoids, proteins and carbohydrates. In case of Hydroxyl Radical Scavenging Activity both the HI extracts showed dose dependant increase in percent inhibition i. e. hydroxyl radical scavenging activity and thereby showed antioxidant activity however PEHI is more potent than MHI in this regard, while in case of Total Reduction Capability both the HI extracts have shown dose dependent increase in absorbance thereby dose dependant total reduction capacity indicating antioxidant activity. Further trend suggest that PEHI has more potent antioxidant potential than that of MHI. The results indicate that petroleum ether and methanol extracts contained such phytochemial compounds which are active in case of antioxidant activity using Hydroxyl Radical Scavenging Activity and Total Reduction Capability. Which support the ethnomedicinal application of the plant as an antioxidant agent.

Keywords: Holoptelea integrifoila leaves, Antioxidant, Hydroxyl Radical Scavenging Activity, Total Reduction Capability. 

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International Journal of Applied Pharmaceutics
Vol 6, Issue 3 (Oct-Dec 2014) Page: 6-8

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Ravindra C Sutar

V K Kalaichelvan


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