EVALUATION OF FAMOTIDINE LOADED 3D-NANO-CELLULOSE NETWORK USED FOR ORAL ADMINISTRATION
Keywords:Famotidine, Prolonged-release, Oral delivery
Objective: Evaluation Of Famotidine Loaded 3D-Nano-Cellulose Network three dimensional nano-cellulose network (3DNC) Used For Oral Administration. 3DNC is produced from bacteria living in fermented green tea and is the material containing nano-sized fibers, which is capable of loading Famotidine to form a prolonged release therapy to improve drug bioavailability.
Methods: Used healthy white rabbits, weight approximately 2.5-2.7 kg, the same age, laboratory standard, is supplied from The National Institute of Drug Quality Control. The rabbits have adapted to laboratory conditions at least one week and have starveling in 12 h, supplied fully water during the preparation. Rabbits are divided into 4 groups (n=3 for each group). Every rabbit is given 1 capsule or 1 tablet with a single dose of 20 mg/rabbit: group 1 (commercial drugs), group 2 (3DNC-standard medium (SM) loaded drug), group 3 (3DNC-coconut medium (CM) loaded drug) Group 4 (3DNC-rice medium (RM) loaded drug).
Results: The results have shown that 3DNC has the involvement of the nano-sized cellulose fibers with three-dimensional networks that are capable of loading Famotidine and prolonged drug release. The 3DNC cultured in the drug-loaded SM with slow-release and slow-release catalysts, the 3DNC was cultured in CMs and tablets with medium release rates, in comparison with the 3DNC was cultured in RM loaded at a rapid release rate in the same pH = 2.
Conclusion: Experiment on rabbits showed that the drug-loaded 3DNCs could help to prolong the drug release, in which the extended-release time of the 3DNC cultured in SM and CM was higher than that of the 3DNC grown in RM. The 3DNC loaded drugs help improve Famotidine bioavailability compared to commercial tablets.
Amin MCIM, Ahmad N. Bacterial cellulose film coating as a drug delivery system: physicochemical, thermal, and drug release properties. Sain Malaysiana 2012;41:561–8.
Huang L., Chen X, Thanh Xuan Nguyen. Nano-cellulose 3D-networks as controlled-release drug carriers. J Mater Chem B 2013;1:2976–84.
Satishbabu BK, Shurtinag R, Sandeep VR. Formulation and evaluation of floating drug delivery system of famotidine. Indian J Pharm Sci 2010;6:738–44.
Anraku M, Hiraga A, Iohara D, Pipkin JD, Uekama K. Slow–release of famotidine from tables consisting of chitosan/sulfobutyl ether β–cyclodextrin composites. Int J Pharm 2015;487:142–7.
Zhu X, Zhang Z, Qi X, Xing J. Preparation of multiple-unit floating-bioadhesive cooperative minitablets for improving the oral bioavailability of famotidine in rats. Drug Delivery 2014;6:459–66.
Maday FM, Khaled KA, Yamasaki K, Iohara D, Taguchi K, Anraku M, et al. Evaluation of carboxymethyl-beta-cyclodextrin with acid function: improvement of chemical stability, oral bioavailability and bitter taste of famotidine. Int J Pharm 2010;397:1–8.
Fahmy RH, Kassem MA. Enhancement of famotidinedissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation. Eur J Pharm Biopharm 2008;3:993-1003.
Gao S, Liu GL, Wang SX, Gao XH. Pharmacokinetics and bioavailability of famotidine in 10 healthy Chinese volunteers. Zhongguo Yao Li Xue Bao 1991;3:195–8.
Thanh Xuan Nguyen. Chitosan–coated nanoliposomes for the oral delivery of berberin hydrochloride. J Mater Chem B 2014;2:7149–59.
Ministry of Health. Pharmacopoeia Vietnam IV. Hanoi Publisher; 2009.
Tran Thị Thu Hang. Clinical Pharmacokinetics, Phuong Dong Publisher; 2009.
Zhang Y, Huo M, Zhou J, Xie S. An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel. Comput Methods Programs Biomed 2010;3:306-4.
Le Thi Phuong Thao, Le Vinh Bao, Nguyen Thien Hai. Formulation of famotidine 40 mg tablet. J Med Sci 2014;2:72-7.
Phan Thi Huyen Vy, Bui Minh Thy, Phung Thi Kim Hue, Nguyen Xuan Thanh, Trieu Nguyen Trung. Method validation for famotidine quantitative analysis in rabbit plasma. J Prac Med 2018;1066:46-50.
Mishra V. Formulation and pharmacokinetic study of famotidine loaded floating microballoons. Int J Pharm Pharm Sci 2012;4:511-5.