• Dr.K.Venkataramana



Objectives: The objective of the current study is to enhance the solubility of Eprosartan mesylate a BCS Class II drug by employing nanoprecipitation technique.

Methods: Polymeric nanoparticles of Eprosartan mesylate were prepared by precipitation technique with various polymers like PVP K30, HPMC K15M, and Eudragit L100 in various ratios. The incompatibility issues which may arise between the drug and polymers are tested by differential scanning calorimetry (DSC). The formed nanosuspensions were evaluated for various parameters like particle size, zeta potential, drug content and dissolution testing.

Results: Among all the nanosuspension formulations, E12 formulation prepared with Eudragit L 100 showed better evaluation characteristics. SEM and DSC analysis showed no major interactions with the excipients. The maximum drug release was showed at 12h. The formulation E12 showed the particle size of 81.5 ± 5.5nm and zeta potential of -55.1mv.

Conclusion: Nano-precipitation method improved the dissolution as well as bioavailability of Eprosartan mesylate nanosuspension.

Key words: Bioavailability, Dissolution, Nanoprecipitation, Eprosartan mesylate, Eudragit.

Keywords: Bioavailability, Dissolution, Nanoprecipitation, Eprosartan mesylate, Eudragit.

Author Biography



A.S.N College of Pharmacy,

Burripalem Road, Tenali

Guntur, Andhrapradesh


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How to Cite
MODALA SANTHOSH RAJA, & K.Venkataramana. (2020). FORMULATION AND EVALUATION OF STABILIZED EPROSARTAN NANOSUSPENSION. International Journal of Applied Pharmaceutics, 12(6). Retrieved from
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