A A COMPARATIVE ASSESSMENT OF VESICULAR FORMULATIONS TRANSFERSOMES AND CONVENTIONAL LIPOSOMES LOADED IVABRADINE HYDROCHLORIDE

  • Gita Chaurasia research scholar

Abstract

Objective: Ivabradine hydrochloride (IH), a benzazepine derivative used to treat cardiovascular disease angina pectoris. In this study IH-loaded novel carrier systems transfersomes (TFs) and conventional liposomes (CLs) were developed and compared for their efficacy to enhance the stability of drug from degradation.  


 Methods: TFs formulations (TF-1, TF-2 & TF-3) were prepared by using different biocompatible surfactants; tween-80 (TW), span-80(S), and sodium deoxycholate (SC) in the concentration ratio of 15 parts with 85 parts of soy Phosphatidylcholine as phospholipid by thin-film hydration method. These vesicles were compared with CLs formulation (L-1) prepared in 7:3 molar ratio of soy Phosphatidylcholine: cholesterol by following the same method. These vesicles were compared for physical appearance, vesicle shape and size, percentage drug entrapment efficiency (%DEE), deformability index (DI), in vitro percentage cumulative drug release study, and physical stability studies. The chosen optimized novel carriers were observed under scanning electron microscopy.


Results: The compared data demonstrated that the physical appearance for all vesicles was turbid and had a spherical shape. The size distribution was in the range of 129.0 nm to 273.5 nm in vesicles. The %DEE (79.0±0.94) and DI (35.0±1.9) were found maximum in TF-1 formulation that was 2.3 times higher than L-1 formulation.  The in vitro percentage cumulative drug release study followed polynomial second-order kinetics that was 2.0 times higher than L-1and 2.9 times higher than the plain drug in 30 min (90.4±0.06%) from TF-1. The vesicles were found to be stable at refrigeration conditions.


Conclusion: Thus, amongst all vesicles, TW loaded TFs (TF-1) were chosen as an excellent novel vesicular carrier for hydrophilic drugs due to its higher deformability behavior than CLs that protects the certain drugs from biodegradation and provides stability.


 


 

Keywords: Ivabradine, Ivabradine hydrochloride, vesicles, Conventional liposomes, Transfersomal preparations

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Chaurasia, G. (2020). A A COMPARATIVE ASSESSMENT OF VESICULAR FORMULATIONS TRANSFERSOMES AND CONVENTIONAL LIPOSOMES LOADED IVABRADINE HYDROCHLORIDE. International Journal of Applied Pharmaceutics, 12(6). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/39391
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