LORNOXICAM-LOADED NANOSPONGES FOR CONTROLLED ANTI-INFLAMMATORY EFFECT: IN VITRO/ IN VIVO ASSESSMENT
Nanosponges for controlled release
The study aim was to design a controlled topical delivery system of lornoxicam (LX) to enhance skin permeation and treatment efficacy. Nanosponges were chosen as novel carrier for this purpose. Nanosponges were formulated via emulsion solvent evaporation method using ethyl cellulose (polymer) and polyvinyl alcohol (surfactant). Nanosponge dispersions were characterized for colloidal properties, entrapment efficiency and in vitro release study. The nanosponge formulation (LS1) was then incorporated into carboxymethyl cellulose sodium hydrogels and evaluated for pH, viscosity and in vitro drug release. Skin irritation was evaluated, and anti-inflammatory activity was assessed via rat hind paw edema method. Nanosponges were in the nano-sized range and attained a uniform round shape with a spongy structure. LS1exhibited the highest LX release after 6 h, so it was incorporated as hydrogel. In vivo study revealed an enhanced anti-inflammatory activity for 6 h (p < 0.001). It can be deduced that the developed nanosponge hydrogel is an efficient nanocarrier for improved and controlled topical delivery of LX.
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