ANTI-ATHEROSCLEROTIC EFFECTS OF SONNERATIA ALBA FRUIT EXTRACT IN ATHEROSCLEROTIC-INDUCED RATS

  • HURIATUL MASDAR Histology Department, Faculty of Medicine, University of Riau, Indonesia
  • MUHAMMAD YULIS HAMIDY Pharmacology Department, Faculty of Medicine, University of Riau, Indonesia
  • DARMAWI Histology Department, Faculty of Medicine, University of Riau, Indonesia
  • RIZFAN TRIHARDI Faculty of Medicine, University of Riau, Indonesia
  • ANDHIKA PERWIRA Faculty of Medicine, University of Riau, Indonesia
  • DELVI UTARI Faculty of Medicine, University of Riau, Indonesia

Abstract

Objective: The aim of this research was to investigate the potential of Sonneratia alba fruit extract to prevent atherosclerosis formation.


Methods: Eighteen male Wistar rats were divided into standard or negative control (S), positive control (P) and treatment (T) groups. Atherosclerosis was induced in groups P and T by orally administering a single dose of Vitamin D3 and a high-fat diet for three days. Sonneratia alba fruit extract was given to the T-group for three days. Lipids were enzymatically measured and foam cells were counted in 10 fields of a microscopic view of the abdominal aorta.


Results: This study showed higher cholesterol, LDL, HDL and triglyceride levels in the T-group, compared to the other groups. The average number of foam cells in the S-, P-and T-groups were 11.8±3.3 cells, 21.2±2.2 cells and 11.7±2.9 cells, respectively. Statistical analysis with One-Way Anova showed a significant difference in the average number of foam cells (p = 0.042). Further analysis showed a significant difference in the average number of foam cells in groups S with P (p = 0.041) and P with T (p = 0.024).


Conclusion: Sonneratia alba fruit extract showed a potential effect to inhibit atherosclerosis process but could not suppress lipid levels in the blood.

Keywords: Atherosclerosis, Foam Cells, Lipid, Mangrove, Sonneratia alba

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MASDAR, H., HAMIDY, M. Y., DARMAWI, TRIHARDI, R., PERWIRA, A., & UTARI, D. (2020). ANTI-ATHEROSCLEROTIC EFFECTS OF SONNERATIA ALBA FRUIT EXTRACT IN ATHEROSCLEROTIC-INDUCED RATS. International Journal of Applied Pharmaceutics, 12(3). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/39467
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