ANTI-ATHEROSCLEROTIC EFFECTS OF SONNERATIA ALBA FRUIT EXTRACT IN ATHEROSCLEROTIC-INDUCED RATS
Abstract
Objective: The aim of this research was to investigate the potential of Sonneratia alba fruit extract to prevent atherosclerosis formation.
Methods: Eighteen male Wistar rats were divided into standard or negative control (S), positive control (P) and treatment (T) groups. Atherosclerosis was induced in groups P and T by orally administering a single dose of Vitamin D3 and a high-fat diet for three days. Sonneratia alba fruit extract was given to the T-group for three days. Lipids were enzymatically measured and foam cells were counted in 10 fields of a microscopic view of the abdominal aorta.
Results: This study showed higher cholesterol, LDL, HDL and triglyceride levels in the T-group, compared to the other groups. The average number of foam cells in the S-, P-and T-groups were 11.8±3.3 cells, 21.2±2.2 cells and 11.7±2.9 cells, respectively. Statistical analysis with One-Way Anova showed a significant difference in the average number of foam cells (p = 0.042). Further analysis showed a significant difference in the average number of foam cells in groups S with P (p = 0.041) and P with T (p = 0.024).
Conclusion: Sonneratia alba fruit extract showed a potential effect to inhibit atherosclerosis process but could not suppress lipid levels in the blood.
References
2. Bakar A. Pengelolaan hutan mangrove dan pemanfaatannya dalam meningkatkan ekonomi masyarakat pesisir pantai provinsi riau. bakar a, purnama p, rahmayuni r. Kutubkhanah 2013;16:94–103.
3. Simlai A, Rai A, Mishra S, Mukherjee K, Roy A. Antimicrobial and antioxidative activities in the bark extracts of sonneratia caseolaris, a mangrove plant. EXCLI J 2014;13:997–1010.
4. Krishnamoorthy M, Sasikumar JM, Shamna R, Pandiarajan C, Sofia P, Nagarajan B. Antioxidant activities of bark extract from mangroves, Bruguiera cylindrica (L.) blume and ceriops decandra perr. Indian J Pharmacol 2011;43:557–62.
5. Ismawati, Oenzil F, Yanwirasti, Yerizel E. Changes in expression of proteasome in rats at different stages of atherosclerosis. Anat Cell Biol 2016;49:99–106.
6. Katouah H, Chen A, Othman I, Gieseg SP. Oxidised low-density lipoprotein causes human macrophage cell death through oxidant generation and inhibition of key catabolic enzymes. Int J Biochem Cell Biol 2015;61:34–42.
7. Paneni F, Beckman JA, Creager MA, Cosentino F. Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part i. Eur Heart J 2013;34:2436–43.
8. Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circulation Res 2010;107:1058–70.
9. Das SK, Samantaray D, Patra JK, Samanta L, Thatoi H. Antidiabetic potential of mangrove plants: a review. Front Life Sci 2016;9:75–88.

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