Dr Abhishek Kanugo LIQUISOLID-PELLETS TECHNIQUE: A RECENT TECHNIQUE FOR ENHANCING SOLUBILITY AND BIOAVAILABILITY OF DRUGS.
The current article aims with introduction of newer solubility enhancing technique as Liquisolid-pellet. Majority of newly invented molecules comes under biopharmaceutical classification system (BCS) Class II and IV indicating poor solubility and thereby poor bioavailability. Liquisolid Compaq is one of the solubility enhancement technique used for improving solubility and dissolution of molecule by incorporating non-volatile solvent followed by carrier and coating agents. But this technique is only applicable for potent molecules as higher dose resulted inconvenience to patient and difficult to swallow. Another drawback of this method is not suitable for pilot plant scale-up. Liquisolid pellet technique overcoming all limitations of Liquisolid Compaq and offers good compaction, flowability, dose accuracy, less gastric irritations and better bioavailability. In Liquisolid-Pellet technique, powdered material received from Liquisolid Compaq is further moistened with granulating fluid so as to provide enough plasticity. The material is subjected for extrusion using extruder to generate extrudates. The extrudates are placed under spheronizer to form spherical particle as Pellets. The pellets are mainly prepared by extrusion-spheronization and hence, articles elaborate details of extruders and spheronizers, their specifications as well as factors which strongly impart processing. These pellets are filled in capsules according to their dose and utilized as immediate release or sustained release.
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