THE COSMETIC EFFECTS OF VARIOUS NATURAL BIOFUNCTIONAL INGREDIENTS AGAINST SKIN AGING: A REVIEW

Authors

  • WISAM NASER Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, 11733 Amman, Jordan

DOI:

https://doi.org/10.22159/ijap.2021v13i1.39806

Keywords:

Nutricosmetics, Cosmeceuticals, Biofunctional ingredients, Anti-aging

Abstract

Nutricosmetics have emerged to indicate the health benefits of the products that create beauty from inside to outside. Nutricosmetic is the latest trend in the beauty industry. Cosmeceuticals are commonly used in skincare regimens to maintainhealthy skin and improve visible signs of aging. Natural products that target skin have gained great attention due to the general belief that they are harmless. A review of the biomedical literature was conducted using peer-reviewed journal articles toidentify laboratory, animal, and clinical studies that have evaluated recent breakthroughs in the biological properties and potential dermatologic uses of the different natural bioactive ingredients used in nutricosmetics and Cosmeceuticals. Bioactive ingredients used in Nutri-cosmeceutical products are derived from collagen, peptides, proteins, vitamins, carotenes, minerals, omega‐3 fatty acids and plant extracts. These ingredients have been shown to provide dermatologic benefits with potential applications for skin regeneration, photoprotection, wound healing, and more.The information provided by this article is valuable to get the picture of the latest trends. In addition, it might be helpful for clinicians and related manufacturing companies. Despite several developments in this field, extensive research is required for performing successful and precise clinical trials in the future. Further improvements would enable the researchers to develop new products in this field.

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References

Kumar P, Singh A. Nanostructured lipid carriers (Nlcs): a prominent topical delivery system for coenzyme Q10 and Myrica esculenta leaves extract for anti-aging potential.Int J Pharm Pharm Sci 2018;10:106-12.

Duarah S, Pujari K, Devi Durai R, Narayanan VHB. Nanotechnology-based cosmeceuticals: a review. Int J Appl Pharm 2016;8:8-12.

Sivamaruthi BS, Chaiyasut C, Kesika P. Cosmeceutical importance of fermented plant extracts: a short review. Int J Appl Pharm 2018;10:31-4.

Mahawar V, Patidar K, Josh N. Development and evaluation of herbal antiaging cream formulation containing Annona Squamosa leaf extract. Asian J Pharm Clin Res 2019;12:210-4.

Mukherjee PK, Maity N, Nema NK, Sarkar BK. Bioactive compounds from natural resources against skin aging. Phytomedicine 2011;19:64-73.

Natarajan VT, Ganju P, Ramkumar A, Grover R, Gokhale RS. Multifaceted pathways protect human skin from UV radiation. Nat Chem Biol 2014;10:542–51.

Jenkins G. Molecular mechanisms of skin ageing. Mech Ageing Dev 2002;123:801-10.

Lorencini M, Brohem CA, Dieamant GC, Zanchin NIT, Maibach HI. Active ingredients against human epidermal aging. Ageing Res Rev 2014;15:100-15.

Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK. Extracellular matrix structure. Adv Drug Delivery Rev 2016;97:4–27.

Tobin DJ. Introduction to skin aging. J Tissue Viability 2017;26:1:37-46.

Sachs DL, Rittie L, Chubb HA, Orringer J, Fisher G, Voorhees JJ. Hypo-collagenesis in photoaged skin predicts response to anti-aging cosmeceuticals. J Cosmet Dermatol 2013;12:108–15.

Sherber NS. Topicals in skin rejuvenation: prescription topicals. Facial Plast Surg 2014;30:12–5.

Fuller B. Role of PGE-2 and other inflammatory mediators in skin aging and their inhibition by topical natural anti-inflammatories. Cosmetics 2019;6:6.

Levakov A, Vuckovic N, Dolai M, Kacanski MM, Bozanic S. Age-related skin changes.Med Pregl 2012;65:191–5.

Kammeyer A, Luiten RM. Oxidation events and skin aging. Ageing Res Rev2015;21:16–29.

Imokawa G. Melanocyte activation mechanisms and rational therapeutic treatments of solar lentigos. Int J Mol Sci 2019;20:3666.

Krutmann J. How the sun ages our skin. The dermis as the driving force. Hautarzt Z Dermatol Venerol Verwandte Geb 2011;62:588–90.

Wenk J, Brenneisen P, Meewes C, Wlaschek M, Peters T, Blaudschun R, et al. UV-induced oxidative stress and photoaging. Curr Probl Dermatol 2001;29:83–94.

Wlaschek M, Tantcheva Poor I, Naderi L, Ma W, Schneider LA, Razi Wolf Z,et al. SolarUV irradiation and dermal photoaging. J Photochem Photobiol B Biol 2001;63:41–51.

Govindan S, Johnson EER, Christopher J, Shanmugam J, Thirumalairaj V, GopalanJ. Antioxidant and anti-aging activities of polysaccharides from Calocybe indica var APK2. Exp Toxicol Pathol 2016;68:329–34.

Carocho M, Ferreira ICFR. A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food Chem Toxicol 2013;51:15–25.

Matsui MS, Hsia A, Miller JD, Hanneman K, Scull H, Cooper KD, et al.Non-sunscreen photoprotection: antioxidants add value to a sunscreen. J Investig Dermatol Symp Proc 2009;14:56–9.

Taofiq O, GonzalezParamas AM, Martins A, Barreiro MF, Ferreira ICFR. Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics-a review. Ind Crops Prod 2016;90:38–48.

Dua D, Srivastava NS. A study on antioxidant and anti-aging properties of few medicinal plants. Int J Pharm Pharm Sci 2016;8:344-7.

Holmes R, Kirk S, Tronci G, Yang X,Wood D. Influence of telopeptides on the structural and physical properties of polymeric and monomeric acid-soluble type I collagen. Mater Sci Eng C Mater Biol Appl 2017;77:823–7.

Daliri EBM, Oh DH, Lee BH. Bioactive peptides. Foods 2017;6:32.

Langmaier F, Mladek M, Kolomazník K, Sukop S. Isolation of elastin and collagen polypeptides from long cattle tendons as raw material for the cosmetic industry. Int J Cosmet Sci 2002;24:273–9.

Liu D, Nikoo M, Boran G, Zhou P, Regenstein JM. Collagen and gelatin. Annu Rev Food Sci Technol 2015;6:527–57.

Leon Lopez A, Fuentes Jimenez L, Hernandez Fuentes AD, Campos Montiel RG, Aguirre Alvarez G. Hydrolysed collagen from sheepskins as a source of functional peptides with antioxidant activity. Int J Mol Sci 2019;20:3931.

Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem 2005;53:6531–6.

Ichikawa S, Morifuji M, Ohara H, Matsumoto H, Takeuchi Y, Sato K. Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate. Int J Food Sci Nutr 2010;61:52–60.

Osawa Y, Mizushige T, Jinno S, Sugihara F, Inoue N, Tanaka H, et al. Absorption and metabolism of orally administered collagen hydrolysates evaluated by the vascularly perfused rat intestine and liver in situ. Biomed Res 2018;39:1–11.

Yamamoto S, Hayasaka F, Deguchi K, Okudera T, Furusawa T, Sakai Y. Absorption and plasma kinetics of collagen tripeptide after peroral or intraperitoneal administration in rats. Biosci Biotechnol Biochem 2015;79:2026–33.

Wu HC, Chen HM, Shiau CY. Free amino acids and peptides as related to antioxidant properties in protein hydrolysates of mackerel (Scomber austriasicus). Food Res Int 2003;36:949–57.

Klompong V, Benjakul S, Yachai M, VisessanguanW, Shahidi F, Hayes KD. Amino acid composition and antioxidative peptides from protein hydrolysates of yellow stripe trevally (Selaroides leptolepis). J Food Sci 2009;74:126–33.

Qian ZJ, Jung WK, Byun HG, Kim SK. Protective effect of an antioxidative peptide purified from gastrointestinal digests of oyster, crassostrea gigas against free radical-induced DNA damage. Bioresour Technol 2008;99:3365–71.

Rajapakse N, Mendis E, JungWK, Je JY, Kim SK. Purification of a radical-scavenging peptide from fermented mussel sauce and its antioxidant properties. Food Res Int 2005;38:175–82.

Mendis E, Rajapakse N, Byun HG, Kim SK. Investigation of jumbo squid (Dosidicus gigas) skin gelatin peptides for their in vitro antioxidant effects. Life Sci 2005;77:2166–78.

Wanga X, Honga H, Wua J. Hen collagen hydrolysate alleviates UVA-induced damage in human dermal fibroblasts. J Funct Foods 2019;63.DOI.ORG/10.1016/J.JFF.2019.103574

Urquiaga I, Leighton F. Plant polyphenol antioxidants and oxidative stress. Biol Res 2000;33:55–64.

Singh IP, Sidana J, Bharate SB, Foley WJ. Phloroglucinol compounds of natural origin: synthetic aspects. Nat Prod Rep 2010;27:393–416.

Moon HE, Islam MN, Ahn BR, Chowdhury SS, Sohn HS, Jung HA, et al. Protein tyrosine phosphatase 1B and alpha-glucosidase inhibitory phlorotannins from edible brown algae, ecklonia stolonifera and eisenia bicyclis. Biosci Biotechnol Biochem 2011;75:1472–80.

Fitton JH, Irhimeh M, Falk N. Macroalgal fucoidan extracts-a new opportunity for cosmetics. Cosmet Toilet 2007;122:55–64.

Melendez Martinez AJ, Stinco CM, Mapelli Brahm P. Skin carotenoids in public health and nutricosmetics: the emerging roles and applications of theUV radiation-absorbing colourless carotenoids phytoene and phytofluene. Nutrients 2019;11:1093.

Palombo P, Fabrizi G, Ruocco V, Ruocco E, Fluhr J, Roberts R, et al. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol Physiol 2007;20:199–210.

Kim MS, Oh GH, Kim MJ, Hwang JK. Fucosterol inhibits matrix metalloproteinase expression and promotes type-1 procollagen production in UVB-induced HaCaT cells. Photochem Photobiol 2013;89:911–8.

Peng J, Yuan JP, Wu CF, Wang JH. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health. Mar Drugs 2011;9:1806–28.

Charlotte J, Ann Dorit MS, Susan LH, Casimir CA, Ditte BH. Source, extraction, characterization, and applications of novel antioxidants from seaweed.

Annu Rev Food Sci Technol 2019;10:541–68.

Podhaisky HP, Wohlrab W. Is the photoprotective effect of vitamin E based on its antioxidative capacity? J Dermatol Sci 2002;28:84–6.

Rossano R, Ungaro N, D’Ambrosio A, Liuzzi GM, Riccio P. Extracting and purifying R-phycoerythrin from mediterranean red algae Corallina elongataellis andsolander. J Biotechnol 2003;101:289–93.

Correa H, Aristizabal F, Duque C, Kerr R. Cytotoxic and antimicrobial activity of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of san andres and providencia islands (southwest Caribbean Sea). Mar Drugs 2011;9:334–44.

Dias MI, Sousa MJ, Alves RC, Ferreira ICFR. Exploring plant tissue culture to improve the production of phenolic compounds: a review. Ind Crops Prod 2016;82:9–22.

Heleno SA, Martins A, Queiroz MJRP, Ferreira ICFR. Bioactivity of phenolic acids: metabolites versus parent compounds: areview. Food Chem 2015;173:501–13.

Zhang H, Tsao R. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr Opin Food Sci 2016;8:33–42.

Jiang K, Li L, Long L, Ding S. Comparison of alkali treatments for efficient release of p-coumaric acid and enzymatic saccharification of sorghum pith. bioresour. Technology 2016;207:1–10.

Pragasam SJ, Murunikkara V, Sabina EP, Rasool M. Ameliorative effect of p-coumaric acid, a common dietary phenol, on adjuvant-induced arthritis in rats. Rheumatol Int 2013;33:325–34.

Pei K, Ou J, Huang J, Ou S. p-Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities. J Sci Food Agric 2016;96:2952–62.

Kwak JY, Park S, Seok JK, Liu KH, Boo YC. Ascorbyl coumarates as multifunctional cosmeceutical agents that inhibit melanogenesis and enhance collagen synthesis. Arch Dermatol Res 2015;307:635–43.

Ouimet MA, Faig JJ, Yu W, Uhrich KE. Ferulic acid-based polymers with glycol functionality as a versatile platform for topical applications. Biomacromolecules 2015;16:2911–9.

Al Danaf N, Melhem RA, Assaf KI, Nau WM, Patra D. Photophysical properties of neutral and dissociated forms of rosmarinic acid. J Lumin 2016;175:50–6.

Li HR, Habasi M, Xie LZ, Aisa HA. Effect of chlorogenic acid on melanogenesis of B16 melanoma cells. Molecules 2014;19:12940–8.

Ruifeng G, Yunhe F, Zhengkai W, Ershun Z, Yimeng L, Minjun Y, et al. Chlorogenic acid attenuates lipopolysaccharide-induced mice mastitis by suppressingTLR4-mediated NF-alfa B signaling pathway. Eur J Pharmacol 2014;729:54–8.

Silambarasan T, Manivannan J, Raja B, Chatterjee S. Prevention of cardiac dysfunction, kidney fibrosis and lipid metabolic alterations in l-NAME hypertensive rats by sinapic acid-role of HMG-CoA reductase. Eur J Pharmacol 2016;777:113–23.

Pandy A, Soccol CR, Mitchell D. New developments in solid state fermentation: I-bioprocesses and products. Process Biochem 2000;35:1153-69.

Pyo YH, Seo SY. Simultaneous production of natural statins and coenzyme Q10 by Monascus pilosus fermentation using different solid substrates. Food Sci Biotechnol 2010;19:1635-41.

Kagan VE, Fabisiak JP, Quinn PJ. Coenzyme Q and vitamin E need each other as antioxidants. Protoplasma 2000;214:11-8.

Rice Evans C, Miller NJ. Total antioxidant status in plasma and body fluids. Methods Enzymol 1994;234:279-93.

Yoo Jeong J, Young Hee P. Effect of Monascus-fermented soybean extracts on antioxidant and skin aging-related enzymes inhibitory activities. Prev Nutr Food Sci 2017;22 Suppl 4:376-80.

Taofiq O, Gonzalez Paramas AM, Martins A, Barreiro MF, Ferreira ICFR. Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics-a review. Ind Crops Prod 2016;90:38–48.

Cheah IK, Halliwell B. Ergothioneine: antioxidant potential, physiological function and role in disease. Biochim Biophys Acta 2012;Suppl 1822:784–93.

Zembron Lacny A, Gajewski M, Naczk M, Siatkowski I. Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise. J Physiol Pharmacol 2013;64:249–54.

Mizuno M, Nishitani Y, Hashimoto T, Kanazawa K. Different suppressive effects of fucoidan and lentinan on IL-8 mRNA expression in in vitro gut inflammation. Biosci Biotechnol Biochem 2009;3:2324–5.

Kamarudzaman AN, Chay TC, Amir A, Talib SA. Biosorption of Mn(II) ions from aqueous solution by pleurotus spent mushroom compost in a fixed-bed column. Procedia Soc Behav Sci 2015;195:2709–16.

Oludemi T, Sandrina AH, Ricardo CC, Maria JA, Lillian B, Maria FB, et al. Development of mushroom-based cosmeceutical formulations with anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial properties.Molecules2016;21:1372.

Taofiq O, Martins A, Barreiro MF, Ferreira ICFR. Anti-inflammatory potential of mushroom extracts and isolated metabolites. Trends Food Sci Technol 2016;50:193–210.

Taofiq O, Calhelha RC, Heleno SA, Barros L, Martins A, Santos Buelga C.The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives. Food Res Int 2015;76:821–7.

Meng TX, Zhang CF, Miyamoto T, Ishikawa H, Shimizu K, Ohga S, et al. The melanin biosynthesis stimulating compounds isolated from the fruiting bodies of Pleurotus citrinopileatus. J Cosmet Dermatol Sci Appl 2012;2:151–7.

Ali SA, Choudhary RK, Naaz I, Ali AS. Understanding the challenges of melanogenesis: key role of bioactive compounds in the treatment of hyperpigmentory disorders. J Pigment Dis 2015;2:1–9.

Yan ZF, Yang Y, Tian FH, Mao XX, Li Y, Li CT. Inhibitory and acceleratory effects of Inonotus obliquus on tyrosinase activity and melanin formation in B16 melanoma cells. Evid Based Complement Med 2014. https://doi.org/10.1155/2014/259836.

Masaki H. Role of antioxidants in the skin: anti-aging effects. J Dermatol Sci 2010;58:85–90.

Hargreaves IP. Coenzyme Q10 as a therapy for mitochondrial disease. Int J Biochem Cell Biol 2014;49:105-11.

Ziosi M, Di Meo I, Kleiner G, Gao XH, Barca E, Sanchez Qintero MJ, et al. Coenzyme Q10 deficiency causes impairment of the sulfide oxidation pathway. EMBO Mole Med 2017;9:96–111.

Zhang M, Dang L, Guo F, Wang X, ZhaoW, Zhao R. Coenzyme Q10 enhances dermal elastin expression, inhibits IL-1 alpha production and melanin synthesis in vitro. Int J Cos Sci 2012;34:273–9.

Muta Takada K, Terada T, Yamanishi H. Coenzyme Q10 protects against oxidative stress induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells. Biofactors 2009;35:435–41.

Knott A, Achterberg V, Mielke H, Sperling G, Dunckelman K, Vogelsang A, et al. Topical treatment with coenzyme Q10-containing formulas improves skin’s Q10 levels and provides antioxidative effects. Biofactors 2015;41:383–90.

Schniertshauer D, Muller S, Mayr T, Sonntag T, Gebhard D, Bergemann J. Accelerated regeneration of ATP levels after irradiation in human skin fibroblasts by coenzyme Q10. Photochem Photobiol 2016;92:488–94.

Kaci M, Belfaffef A, Meziane S, Dostert G, Menu P, Velot E. Nanoemulsions and topical creams for the safe and effective delivery of lipophilic antioxidant coenzyme Q10. Colloids SurfacesB: Biointerfaces 2018;167:165–75.

Zmitke K, Pogacnik T, Mervic L, Zmitek J, Pravst I. The effect of dietary intake of coenzyme Q10 of skin parameters and condition: results of a randomized, placebo-controlled, double-blind study. Biofactors 2017;43:132–40.

Min CK, Silvia Y, Sun YK. Oral Intake of collagen peptide attenuates ultraviolet b irradiation-induced skin dehydration in vivo by regulating hyaluronic acid synthesis. Int J Mol Sci 2018;19:3551.

Shin JS, Han HS, Lee SB, Myung DB, Lee K, Lee SH, et al. Chemical constituents from leaves of Hydrangea serrata and their anti-photoaging effects on UVB-irradiated human fibroblasts. Biol Pharm Bull 2019;42:424–31.

Han HS, Shin JS, Myung DB, Ahn HS, Lee SH, Kim HJ, et al.Hydrangea serrata (Thunb.) serextract attenuate UVB-induced photoaging through MAPK/AP-1 inactivation in human skin fibroblasts and hairless mice. Nutrients 2019;11:533.

Da-Bin M, Jeong Hun L, Hee Soo H, Kwang Young L, Hye Shin A, Yu Kyong S, et al. Oral Intake of Hydrangea serrata (Thunb.) ser leaves extract improves wrinkles, hydration, elasticity, texture, and roughness in human skin: a randomized, double-blind, placebo-controlled study. Nutrients 2020;12:1588.

Defeng Xu, Dan Li Zijian Z, Jiaxin L, Mouming Z. Regulation of walnut protein hydrolysate on the components and structural degradation of photoaged skin in SD rats. Food Funct 2019. DOI:10.1039/C8FO01833B.

Chen XQ, Nagao N, Itani T, Irifune K. Anti-oxidative analysis, and identification and quantification of anthocyanin pigments in different coloured rice. Food Chem 2012;135:2783–8.

Shao K, Hu Z, Yu Y, Mou R, Zhu Z, Beta T. Phenolic acids, anthocyanins, proanthocyanidins, antioxidant activity, minerals and their correlations in non-pigmented, red, and black rice. Food Chem 2018;239:733–41.

Kim HJ, Tsoy I, Park JM, Chung JI, Shin SC, Chang KC. Anthocyanins from soybean seed coat inhibit the expression of TNF-α-induced genes associated with ischemia/reperfusion in endothelial cell by NF-κB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo. FEBS Lett 2006;580:1391–7.

He YH, Zhou J, Wang YS. Anti-inflammatory and anti-oxidative effects of cherries on Freund’s adjuvant induced arthritis in rats. Scand J Rheumatol2006;35:356–8.

Palungwachira P, Tancharoen S, Phruksaniyom C, Klungsaeng S. Antioxidant and anti-inflammatory properties of anthocyanins extracted from Oryza sativa L. in primary dermal fibroblasts. Oxid Med Cell Longev 2019. https://doi.org/10.1155/2019/2089817.

Fernandes MF, Conegundes JLM, Pinto NCC, Oliveira LG.Cecropia pachystachyaleaves present potential to be used as new ingredient for antiaging dermocosmetics. J EvidenceBased Complementary Altern Med 2019. https://doi.org/10.1155/2019/8263934

Działo M, Mierziak J, Korzun U, Preisner M, Szopa J, Kulma A. The potential of plantphenolics in prevention and therapy of skin disorders. Int J Mol Sci 2016;17:160.

Suto M,Masutomi H,Ishihara K, Masaki H. A potato peel extract stimulates type i collagen synthesis via akt and erk signaling in normal human dermal fibroblasts.Biol Pharm Bull 2019;42:1510–6.

Eshun K, He Q. Aloe vera:a valuable ingredient for the food, pharmaceutical and cosmetic industries--a review. Crit Rev Food Sci Nutr 2004;44:91-6.

Laneri S1, Di Lorenzo RM, Bernardi A, Sacchi A, Dini I. Aloe barbadensis:aplant of nutricosmetic interest. Nat Prod Commun 2020;15 Suppl 7:1–6.

Seong JC,Sung Nae L,KaramK, Da H, Shanghun S,Jeongju L, et al.Biological effects of rutin on skin aging. Int J Mol Med 2016;38:357-63.

Ruchi K, Neeraj U, Megha J. Exploring the potential effect of methanolic extract ofSalvia officinalis against UV exposed skin aging: in vivo and in vitro model. Curr Aging Sci 2019. DOI:10.2174/1874609812666190808140549.

Sun IC, Jong SL, Sarah L, BongYeon C, SeungHyun C, Xionggao H, et al. Protective effects and mechanisms of Pourthiaea villosa (Thunb.) decne. Extract on hydrogen peroxide-induced skin aging in human dermal fibroblasts. J Med Food 2019;22:8:841–50.

Nicolai E, Sinibaldi F, Sannino G, Lagana G, Basoli F, Licoccia S. Omega-3 and Omega-6 fatty acids act as inhibitors of the matrix metalloproteinase-2 and matrix metalloproteinase-9 activity. Protein J 2017;36:278-85.

Jo WS, Yang KM, Park HS, Kim GY, Nam BH, Jeong MH, et al. Effect of microalgal extracts of tetraselmissuecica against UVB-induced photoaging in human skin fibroblast. Toxicol Res 2012;28:241-8.

Zielinska A, Nowak I. Abundance of active ingredients in sea-buckthorn oil. Lipids Health Dis 2017;16:95.

Song IB, Gu H, Han HJ, Lee NY, Cha JY, Son YK. Effects of 7-MEGATM 500 on oxidative stress, inflammation, and skin regeneration in H2O2-treated skin cells. Toxicol Res 2018;34:103-10.

Kyo-Hyun P, JiYeon K, Suryun J, Kyung-hwa S, Yeon-Kyoung S, Jung Min B, et al.Alleviation of ultraviolet b-induced photoaging by 7-MEGATM 500 in hairless mouse skin. Toxicol Res 2019;35:4:353-9.

Cho S, Won CH, Lee DH, Lee MJ, Lee S, So SH, et al. Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized, double-blind, placebo-controlled study. J Med Food 2009;12:1252–9.

Sumiyoshi M, Kimura Y. Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation induced skin damage in melanin-possessing hairless mice. Phytomedicine 2009;16:1137–43.

Mula S, Banerjee D, Patro BS, Bhattacharya S, Barik A, Bandyopadhyay SK, et al. Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages. Bioorg Med Chem 2008;16:2932–8.

Cimino F, Cristani M, Saija A, Bonina FP, Virgili F. Protective effects of a red orange extract on UVB-induced damage in human keratinocytes. Biofactors 2007;30:129–38.

Hidalgo ME, Gonzalez I, Toro F, Fernandez E, Speisky H, Jimenez I. Boldine as a sunscreen, its photoprotector capacity against UVB radiation. Cosmet Toiletries 1998;113:59–66.

Rancan F, Rosan S, Boehm K, Fernandez E, Hidalgo ME, Quihot W, et al. Protection against UVB irradiation by natural filters extracted from lichens. J Photochem Photobiol 2002;68:133–9.

Fujii T, Wakaizumi M, Ikami T, Saito M. Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts. J Ethnopharmacol 2008;119:53-7.

Ozkur MK, Bozkurt MS, Balabanli B, Aricioglu A, Ilter N.The effects of EGB 761 on lipid peroxide leaves and superoxide dismutase activity in sunburn. Photodermatol Photoimmunol Photomd 2002;18:117-20.

Tanaka K, Hasegawa J, Asamitsu K, Okamoto T. Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kB. Eur J Pharmacol 2007;565:212–9.

El‐Haj N, Goldstein N. Sun protection in a pill: the photoprotective properties of Polypodium leucotomos extract. Int J Dermatol 2015;54:362–6.

Che DN, Xie GH, Cho BO, Shin JY, Kang HJ, Jang SI. Protective effects of grape stem extract against UVB-induced damage in C57BL mice skin. J Photochem Photobiol B Biol 2017;173:551–9.

Costa A, Pereira ESP, Assumpcao EC, dos Santos FBC, Ota FS, de Oliveira Pereira M,et al. Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men. Clin Cosmet Investig Dermatol 2015;8:319–28.

Pullar J, Carr A, Vissers M. The roles of vitamin C in skin health. Nutrients 2017;9:866.

Petruk G, Raiola A, Del Giudice R, Barone A, Frusciante L, Rigano MM, et al. An ascorbic acid enriched tomato genotype to fight UVA-induced oxidative stress in normal human keratinocytes. J Photochem Photobiol B Biol 2016;163:284–9.

HughesFormella BJ, Bohnsack K, Rippke F, Benner G, Rudolph M, Tausch I, et al. Anti-inflammatory effect of hamamelis lotion in a UVB erythema test. Dermatology 1998;196:316–22.

Hughes Formellam BJ, Filbry A, Gassmueller J, Rippke F. Anti-inflammatoryefficacy of topical preparations with 10% hamamelis distillate in a UV erythema test. Skin Pharmacol Appl Skin Physiol 2002;15:125–32.

Xia Q, Ma Q, Shi JA, Duan TTX, Dong KW, Tsim K. Chemical analysis of Radixastragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. J Agric Food Chem 2002;50:4861–6.

King'Ori AM. A review of the uses of poultry eggshells and shell membranes. Int J Poult Sci 2011;10:11:908–12.

Hsu MF, Chiang BH. Stimulating effects of Bacillus subtilis natto-fermented Radix astragali on hyaluronic acid production in human skin cells. J Ethnopharmacol 2009;125:474–81.

Manosroi A, Jantrawut P, Akihisa T, Manosroi W, Manosroi J. In vitro anti-aging activities of Terminalia chebula gall extract. Pharm Biol 2010;48:469–81.

Kim SJ, Sancheti SA, Sancheti SS, Um BH, Yu SM, Seo SY. Effect of 1,2,3,4,6-penta-O-galloyl-ß-D-glucose on elastase and hyaluronidase activities and its type II collagen expression. Acta Polon Pharm: Drug Res 2010;67:145–50.

Li YH, Wu Y, Wei HC, Xu YY, Jia LL, Chen J, et al. Protective effects of green tea extracts on photoaging and photommunosuppression. Skin Res Technol 2009;15:338–45.

Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res 2010;302:71–83.

Chiu AE, Chan JL, Kern DG, Kohler S, Rehmus WE, Kimball AB. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg 2005;31:855–60.

Mostafa DM, Ammar NM, Abd El-Alim SH, El-anssary AA. Transdermal microemulsions of Glycyrrhiza glabra L.: characterization, stability and evaluation of antioxidant potential. Drug Delivery 2014;21:130–9.

Castangia I, Caddeo C, Manca ML, Casu L, Latorre AC, DiezSales O. Delivery of liquorice extract by liposomes and hyalurosomes to protect the skin against oxidative stress injuries. Carbohydr Polym 2015;134:657–63.

Ndiaye M, Philippe C, Mukhtar H, Ahmad N. The grape antioxidant resveratrol for skin disorders: promise, prospects, and challenges. Arch Biochem Biophys 2011;508:164–70.

Lephart ED, Sommerfeldt JM, Andrus MB. Resveratrol: influences on gene expression in human skin. J Funct Foods 2014;10:377–84.

Raajshree RK, Durairaj B. Evaluation of the antityrosinase and antioxidant potential of zinc oxide nanoparticles synthesized from the brown seaweed-Turbinaria conoides. Int J Appl Pharm2017;9:116-20.

Published

07-01-2021

How to Cite

NASER, W. (2021). THE COSMETIC EFFECTS OF VARIOUS NATURAL BIOFUNCTIONAL INGREDIENTS AGAINST SKIN AGING: A REVIEW. International Journal of Applied Pharmaceutics, 13(1), 10–18. https://doi.org/10.22159/ijap.2021v13i1.39806

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Section

Review Article(s)