• CHANDRAPRABHA UPADHYAY Faculty of Pharmacy, B.N. University, Udaipur, Rajasthan, 313001
  • Meenakshi Bharkatiya Faculty of Pharmacy, B.N. University, Udaipur, Rajasthan, 313001


Objective: This study aimed to develop and in vitro characterize an organogel (OG) loaded ibuprofen. 
Methods: Organogel (OG) composed of water, isooctane and sorbitan esters, sorbitan monopalmitate (Span-40), and poly(oxyethylene)sorbitan monostearate (Polysorbate-60), was loaded with Ibuprofen. The partial phase behavior of ibuprofen OG was studied to optimize the formulation composition. 1.0% w/w Ibuprofen loaded OG were characterize for rheological, in vitro release and stability study.   
Results: Phase diagram showed an isotropic gel region at low water contents, which converted to emulsion on increasing water quantity. The rheological properties of the OG incorporating 1.0% w/w ibuprofen shows the presence of two Tg’s and elastic behavior of gel, reflects the presence of an entangled network of aqueous tubules. The fractal dimension df value of 2.1 and 2.3 was obtained for the two curves (elastic and storage modulus), which is indicative of the formation of the densest gel structure. The diffusional release exponent (n) was found to be ~0.7 (0.5 < n < 1), which is indicative of non-Fickian, anomalous diffusion of the drug from the OG. The in vitro drug release exhibited release @7.04%/h0.7/cm2 from the OG. Ibuprofen containing OG was stable for 28 days in terms of chemical potency and gel stiffness at 4°C and room temperature (~25 °C).
Keywords: Microemulsion, organogel, phase-behavior, gel-sol transition temperature, fractal dimension, Ibuprofen, in-vitro release, pharmacokinetics.


1. Tombs EL, Nikolaou V, Nurumbetov G, et al. Transdermal Delivery of Ibuprofen Utilizing a Novel Solvent-Free Pressure-sensitive Adhesive (PSA): TEPI® Technology. J Pharm Innov. 2018;13(1):48-57.
2. Rajesh K, Pitchaimani R. Formulation of transdermal drug delivery system. Curr Drug Discov Technolo. 2006;3:279e285.
3. Miller MA, Pisani E. The cost of unsafe injections. Bull World Health Organ. 1999;77(10):808-11.
4. Akhtar N, Singh V, Yusuf M, et al. Non-invasive drug delivery technology: development and current status of transdermal drug delivery devices, techniques and biomedical applications. Biomedical Engineering / Biomedizinische Technik. 2020;65(3):243.
5. Watkinson AC, Kearney M-C, Quinn HL, et al. Future of the transdermal drug delivery market – have we barely touched the surface? Expert Opin Drug Deliv. 2016;13(4):523-532.
6. Aziz ZAA, Nasir HM, Ahmad A, et al. Enrichment of Eucalyptus oil nanoemulsion by micellar nanotechnology: transdermal analgesic activity using hot plate test in rats’ assay. Sci Rep. 2019 ;9(1):13678.
7. Kumar L, Verma S, Singh M, et al. Advanced Drug Delivery Systems for Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs: A Review. Curr Drug Deliv. 2018;15(8):1087-1099.
8. Ngo VTH, T B. Ibuprofen. [Updated 2020 May 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020.
9. Bushra R, Aslam N. An overview of clinical pharmacology of Ibuprofen. Oman Med J. 2010;25(3):155-1661.
10. Zhou X, Hao Y, Yuan L, et al. Nano-formulations for transdermal drug delivery: A review. Chinese Chemical Letters. 2018;29(12):1713-1724.
11. Esposito CL, Kirilov P, Roullin VG. Organogels, promising drug delivery systems: an update of state-of-the-art and recent applications. Journal of Controlled Release. 2018;271:1-20.
12. E. Perez, S. Franceschi-Messant, I. Rico-Lattes, et al. Microporous organogel absorbing/solubilising materials, in US patent 9475045 B2. 2014.
13. Vigato AA, Querobino SM, de Faria NC, et al. Physico-Chemical Characterization and Biopharmaceutical Evaluation of Lipid-Poloxamer-Based Organogels for Curcumin Skin Delivery [Original Research]. Front Pharmacol. 2019;10(1006).
14. Sharma G, Devi N, Thakur K, et al. Lanolin-based organogel of salicylic acid: evidences of better dermatokinetic profile in imiquimod-induced keratolytic therapy in BALB/c mice model. Drug Deliv Transl Res. 2018;8(2):398-413.
15. Vigato AA, Querobino SM, de Faria NC, et al. Synthesis and characterization of nanostructured lipid-poloxamer organogels for enhanced skin local anesthesia. European Journal of Pharmaceutical Sciences. 2019;128:270-278.
16. Vintiloiu A, Leroux J-C. Organogels and their use in drug delivery — A review. Journal of Controlled Release. 2008;125(3):179-192.
17. Alfieri ML, Pilotta G, Panzella L, et al. Gelatin-Based Hydrogels for the Controlled Release of 5,6-Dihydroxyindole-2-Carboxylic Acid, a Melanin-Related Metabolite with Potent Antioxidant Activity. Antioxidants (Basel). 2020;9(3):245.
18. Sagiri SS, Singh VK, Kulanthaivel S, et al. Stearate organogel-gelatin hydrogel based bigels: physicochemical, thermal, mechanical characterizations and in vitro drug delivery applications. J Mech Behav Biomed Mater. 2015;43:1-17.
19. Murashova NM, Yurtov EV. Lecithin organogels as prospective functional nanomaterial. Nanotechnologies in Russia. 2015;10(7):511-522.
20. Chang C-E, Hsieh C-M, Chen L-C, et al. Novel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer. Drug Delivery. 2018; 25(1):632-643.
21. Alsaab H, Bonam S, Bahl D, et al. Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels. Journal of Pharmacy and Pharmaceutical Sciences. 2016 ;19:252-273.
22. Rajpoot K. Acyclovir-loaded sorbitan esters-based organogel: development and rheological characterization. Artificial Cells, Nanomedicine, and Biotechnology. 2016;45:1-9.
23. Upadhyay KK, Tiwari C, Khopade AJ, et al. Sorbitan ester organogels for transdermal delivery of sumatriptan. Drug Dev Ind Pharm. 2007;33(6):617-25.
24. Pisal S, Shelke V, Mahadik K, et al. Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride. AAPS PharmSciTech. 2004;5(4):e63-e63.
25. Mohanty B, Bohidar HB. Microscopic structure of gelatin coacervates. Int J Biol Macromol. 2005;36(1-2):39-46.
26. Muthukumar M. Screening effect on viscoelasticity near the gel point. Macromolecules. 1989;22(12):4656-4658.
27. Peppas NA, Brannon-Peppas L. Water diffusion and sorption in amorphous macromolecular systems and foods. Journal of Food Engineering. 1994; 22(1):189-210.
28. Eraga SO, Arhewoh MI, Chibuogwu RN, et al. A comparative UV?HPLC analysis of ten brands of ibuprofen tablets. Asian Pacific Journal of Tropical Biomedicine. 2015 ;5(10):880-884.
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UPADHYAY, C., & Bharkatiya, M. (2021). IBUPROFEN LOADED ORGANOGEL: DEVELOPMENT AND CHARACTERIZATION. International Journal of Applied Pharmaceutics, 13(2). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/40108
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