IBUPROFEN LOADED ORGANOGEL: DEVELOPMENT AND CHARACTERIZATION
Objective: This study aimed to develop and in vitro characterize an organogel (OG) loaded Ibuprofen.
Methods: Organogel (OG) composed of water, isooctane, sorbitan esters, sorbitan monopalmitate (Span-40), and poly(oxyethylene) sorbitan monostearate (Polysorbate-60) was loaded with Ibuprofen. The partial phase behavior of ibuprofen OG was studied to optimize the formulation composition. 1.0% w/w Ibuprofen loaded OG were characterize for rheological, in vitro release and stability study.
Results: Phase diagram showed an isotropic gel region at low water contents, which converted to emulsion on increasing water quantity. The rheological properties of the OG incorporating 1.0% w/w Ibuprofen shows the presence of two Tg’s and elastic behavior of gel, reflects the presence of an entangled network of aqueous tubules. The fractal dimension df value of 2.1 and 2.3 was obtained for the two curves (elastic and storage modulus), which is indicative of the formation of the densest gel structure. The diffusional release exponent (n) was found to be ~0.7 (0.5<n<1), which is indicative of non-Fickian, anomalous diffusion of the drug from the OG. The in vitro drug release exhibited release @ 7.04%/h 0.7/cm2 from the OG. Ibuprofen containing OG was stable for 28 d in terms of chemical potency and gel stiffness at 4 °C and room temperature (~25 °C).
Conclusion: The study indicates the potential of OG for improved transdermal delivery of Ibuprofen.
2. Jayprakash R, Hameed J, Anupriya. An overview of the transdermal delivery system. Asian J Pharm Clin Res 2017;10:36-40.
3. Abualhasan M, Assali M, Jaradat N. Synthesis and formulation of ibuprofen pro-drugs for enhanced transdermal absorption. Int J Pharm Pharm Sci 2015;7:352-4.
4. Akhtar N, Singh V, Yusuf M. Non-invasive drug delivery technology: development and current status of transdermal drug delivery devices, techniques and biomedical applications. Biomedical Engineering/Biomedizinische Technik 2020; 65:243.
5. Watkinson AC, Kearney MC, Quinn HL. Future of the transdermal drug delivery market–have we barely touched the surface? Expert Opin Drug Delivery 2016;13:523-32.
6. Aziz ZAA, Nasir HM, Ahmad A. Enrichment of eucalyptus oil nanoemulsion by micellar nanotechnology: transdermal analgesic activity using hot plate test in rats’ assay. Sci Rep 2019;9:13678.
7. Kumar L, Verma S, Singh M. Advanced drug delivery systems for transdermal delivery of non-steroidal anti-inflammatory drugs: a review. Curr Drug Delivery 2018;15:1087-99.
8. Ngo VTH, TB Ibuprofen. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020.
9. Bushra R, Aslam N. An overview of clinical pharmacology of Ibuprofen. Oman Med J 2010;25:155-66.
10. Zhou X, Hao Y, Yuan L. Nano-formulations for transdermal drug delivery: a review. Chinese Chem Lett 2018;29:1713-24.
11. Esposito CL, Kirilov P, Roullin VG. Organogels, promising drug delivery systems: an update of state-of-the-art and recent applications. J Controlled Release 2018;271:1-20.
12. Fayez SM, Gad S. Formulation and evaluation of etodolac lecithin organogel transdermal delivery systems. Int J Pharm Pharm Sci 2005;7:325-34.
13. Vigato AA, Querobino SM, de Faria NC. Physico-chemical characterization and biopharmaceutical evaluation of lipid-poloxamer-based organogels for curcumin skin delivery. Front Pharmacol 2019;10:1006.
14. Sharma G, Devi N, Thakur K. Lanolin-based organogel of salicylic acid: evidences of better dermatokinetic profile in imiquimod-induced keratolytic therapy in BALB/c mice model. Drug Delivery Transl Res 2018;8:398-413.
15. Vigato AA, Querobino SM, de Faria NC. Synthesis and characterization of nanostructured lipid-poloxamer organogels for enhanced skin local anesthesia. Eur J Pharm Sci 2019;128:270-8.
16. Vintiloiu A, Leroux JC. Organogels and their use in drug delivery-a review. J Controlled Release 2008;125:179-92.
17. Alfieri ML, Pilotta G, Panzella L. Gelatin-based hydrogels for the controlled release of 5,6-dihydroxyindole-2-carboxylic acid, a melanin-related metabolite with potent antioxidant activity. Antioxidants (Basel) 2020;9:245.
18. Sagiri SS, Singh VK, Kulanthaivel S. Stearate organogel-gelatin hydrogel-based bigels: physicochemical, thermal, mechanical characterizations and in vitro drug delivery applications. J Mech Behav Biomed Mater 2015;43:1-17.
19. Murashova NM, Yurtov EV. Lecithin organogels as prospective functional nanomaterial. Nanotechnol Russ 2015;10:511-22.
20. Chang CE, Hsieh CM, Chen LC. Novel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer. Drug Delivery 2018;25:632-43.
21. Alsaab H, Bonam S, Bahl D. Organogels in drug delivery: a special emphasis on pluronic lecithin organogels. J Pharm Pharm Sci 2016;19:252-73.
22. Rajpoot K. Acyclovir-loaded sorbitan esters-based organogel: development and rheological characterization. Artif Cells Nanomed Biotechnol 2016;45:1-9.
23. Upadhyay KK, Tiwari C, Khopade AJ. Sorbitan ester organogels for transdermal delivery of sumatriptan. Drug Dev Ind Pharm 2007;33:617-25.
24. Pisal S, Shelke V, Mahadik K. Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride. AAPS PharmSciTech 2004;5:e63.
25. Mohanty B, Bohidar HB. Microscopic structure of gelatin coacervates. Int J Biol Macromol 2005;36:39-46.
26. Muthukumar M. Screening effect on viscoelasticity near the gel point. Macromolecules 1989;22:4656-8.
27. Peppas NA, Brannon-Peppas L. Water diffusion and sorption in amorphous macromolecular systems and foods. J Food Eng 1994;22:189-210.
This work is licensed under a Creative Commons Attribution 4.0 International License.