THE RESEARCH UPDATES AND PROSPECTS OF HERBAL HARD-BOILED LOZENGES: A CLASSICAL PLATFORM WITH PROMISING DRUG DELIVERY POTENTIAL

  • MANAS RANJAN SAHOO Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, India
  • MARAKANAM SRINIVASAN UMASHANKAR Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, India, 603203
  • RAMESH RAGHAVA VARIER AVN Ayurveda Formulation Pvt Ltd, Madurai, Tamilnadu, India, 625004

Abstract

Over the past decades major focus has been given towards innovative drug delivery systems and new dosage forms. This is due to highly expensive process and high attrition rates of existing marketed drugs. Hard-boiled lozenges (HBLs) are one of the solid dosage form designed to release the drug in saliva for either local or systemic effects. Typical application of lozenegs includes throat infection, pharyngitis, cough suppressant, nasal-decongestant, expectorants, and smoking cessation. The drug delivery through the hard-boiled candies has an easy marketing advantage due to its attractive appearance and patient compliance. As a part of the drug is absosrbed into systemic circulation, gastrointestinal degradation and fast pass effects are avoided. Further, drug delivery through hard-boiled lozenges can be potential platform for some of the suitable drug candidates. This review on hard-boiled lozenges discusses manufacturing process, characterization techniques, quality control, research studies and market potential of hard-boiled lozenges. The major databases searched were, PubMed, Wiley Online, Medline, Elsevier, Google scholar, Scopus, ACS, The Royal Society of Chemistry, SciFinder, Baidu Scholars, CNKI, web of science, Cochrane database, US Patents, Espacenet and various business reviews. This review provides comprehensive information on hard-boiled lozenges that will help the pharmaceutical scientist from academia as well pharmaceutical industry to leverage the potential of this conventional dosage form for various herbal drugs and other pharmaceutical actives.

Keywords: Medicated hard-boiled lozenges, Herbal drug, Drug delivery, Dosage form, Formulation, Characterization

Author Biographies

MARAKANAM SRINIVASAN UMASHANKAR, Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, India, 603203

Dr. M.S. Umashankar working as a professor in department of Pharmaceutics in SRM College of Pharmacy under SRM Institute of Science and Technology (formerly known as SRM University). His research interest includes Formulation and Development of mucoadhesive dosage devices, Novel drug delivery system, vascular drug delivery devices and formulation development of nano-drug delivery. He is having several publications in various research journal in the field of pharmaceutical sciences.

RAMESH RAGHAVA VARIER, AVN Ayurveda Formulation Pvt Ltd, Madurai, Tamilnadu, India, 625004

Dr. Ramesh R Varier is an eminent personality in the area of Ayurveda and is a Managing doctor of the company AVN Ayurveda Formulation Pvt Ltd. He has presented many invited scientific talks about Ayurveda and modern technology. Dr. Ramesh brings with him a rich experience spanning over 25 years of successful Ayurvedic clinical practice. Keenly interested in integrating modern scientific principles with traditional Ayurvedic concepts, Dr Ramesh has been highly successful in establishing comprehensive healthcare solutions for a variety of chronic diseases. He is the a very creative person and has been the one to conceive and implement the Hospital project. Being a gifted orator, Dr Ramesh has made innumerable presentations at many national & international conferences and at various universities worldwide. He has presented papers on various health-related topics & has also been conducting continued medical education programs for Indian & foreign students.


Research endeavors:

  • He  headed the team that Successfully converted traditional Ayurvedic formulations called Kashayams (Liquid extracts) into tablets and launched the same  in the market.
  • He Formulated more than 20 Proprietary Formulations for specific ailments from traditional Ayurvedic preparations and successfully launched them.    
  • He is Engaged in developing integrated understanding and specialized Ayurvedic treatments for a range of chronic ailments.

References

1. Muhammad I, Sumeira R, Quratulain B, Muhammad IQ, Farhat J, Ahmed K. Orally disintegrating films: a modern expansion in drug delivery system. Saudi Pharm J 2016;24:537-46.
2. Hao Zhong, Ging Chan, Yuanjia Hu, Hao Hu, Defang Ouyang. A comprehensive map of FDA-approved pharmaceutical products. Pharmaceutics 2018;10:263.
3. Shoko N, Katsuhiko Y, Yuta A, Yukihiro I. Impact of physicochemical profiling for rational approach on drug discovery. Chem Pharm Bull 2013;61:1228-38.
4. Shripathy D, Addai RS, Gladson SA, Ravi GS, Srinivas H, Akhilesh D. Fast dissolving oral film of piroxicam: solubility enhancement by forming an inclusion complex with ?-cyclodextrin, formulation and evaluation. J Young Pharm 2019;11:1-6.
5. Susan Hua. Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration, front. Pharmacology 2019;10:128.
6. Deepika M, Aparna C, Prathima S. Formulation, evaluation and characterization of itraconazole lozenges. IOSR J Pharm Biol Sci 2004;9:86-94.
7. Rajesh K, Mahalaxmi R, Deepak K. Investigating the suitability of Isomalt and liquid glucose as sugar substitute in the formulation of salbutamol sulfate hard candy lozenges. J Chem Pharm Res 2011;3:69-75.
8. Stephen OM. A review on lozenges. AJMMS 2015;5:99-104.
9. Farrer F. Sprays and lozenges for sore throats. S Afr Fam Pract 2012;2:120-2.
10. Surbhi C. Review on lozenges for bacterial infection. IJRSFP 2017;7:16-22.
11. Katharina T, Sina IG, Sandra K. Bioequivalence of locally acting lozenges: evaluation of critical in vivo parameters and first steps towards a bio-predictive in vitro test method. Eur J Pharm Biopharm 2018;123:71–83.
12. Grembecka M. Sugar alcohol-their role in the modern world of sweeteners: a review. Eur Food Res Tech 2015;241:1-14.
13. Hearnden V, Sankar V, Hull K. New developments and opportunities in oral mucosal drug delivery for local and systemic disease. Adv Drug Delivery Rev 2012;64:16-28.
14. Lam JK, Xu Y, Worsley A. Oral transmucosal drug delivery for pediatric use. Adv Drug Delivery Rev 2014;73:50-62.
15. Michael JR, Indiran P, Sevda S. Overview of oral mucosal delivery in a Michael JR, Sevda S, Indiran P. Advances in Delivery Science and Technology, Springer Boston, MA; 2015. p. 17-26.
16. Jensdottir T, Nauntofte B, Buchwald C, Bardow A. Effects of sucking acidic candy on whole-mouth saliva composition. Caries Res 2005;39:468-74.
17. Lee A, Wils D, Zumbe A, Storey DM. The comparative gastrointestinal responses of children and adults following consumption of sweets formulated with sucrose, isomalt and lycasin HBC. Eur J Clin Nutr 2002;56:755-64.
18. Michael MC, Feng Z, Michael AR, Sridhar T, Sampada BU, Sunil KB, et al. Pharmaceutical applications of hot-melt extrusion: Part I. Drug Dev Ind Pharm 2007;33:909-26.
19. Mandel L, Carunchio MJ. Rampant caries from oral transmucosal fentanyl citrate lozenge abuse. J Am Dent Assoc 2011;142:406-9.
20. Collins AE, Deasy PB. Bioadhesive lozenge for the improved delivery of cetylpyridinium chloride. J Pharm Sci 1990;79:116-9.
21. Johnson D, Mead R, Kennelty K, Hahn D. Menthol cough drops: cause for concern? J Am Board Fam Med 2018;31:183-91.
22. Hemila H, Haukka J, Alho M, Vahtera J, Kivimaki M. Zinc acetate lozenges for the treatment of the common cold: a randomised controlled trial. Br Med J Open 2020;10:e031662.
23. Boyle S, Walters MR. Clinically significant interaction between warfarin and popular cough lozenges 'Fisherman's Friend'. Br Med J Case Rep 2011;28:bcr0920114791.
24. Rampurna PG. Soft gelatin capsules (Softgels). J Pharm Sci 2010;99:4107-48.
25. Basavaraj S, Guru VB. Can formulation and drug delivery reduce attrition during drug discovery and development-review of feasibility, benefits and challenges. Acta Pharm Sin B 2014;4:3-17.
26. Leslie ZB, The role of BCS (Biopharmaceutics classification system) and BDDCS (Biopharmaceutics drug disposition classification system) in drug development. J Pharm Sci 2013;102:34–42.
27. Krithika K, Rajib G. Bioavailability enhancers of herbal origin: an overview. Asian Pac J Trop Biomed 2013;3:253-66.
28. Nannan G, Mengran G, Qiang F, Zhonggui H. Application of hot melt extrusion to enhance the dissolution and oral bioavailability of oleanolic acid. Asian J Pharm Sci 2017;12:66-72.
29. Ritesh AF, Tarique SM, Ajay RS, Purnima DA. Artemether-soluplus hot-melt extrudate solid dispersion systems for solubility and dissolution rate enhancement with amorphous state characteristics. J Pharm 2013. https://doi.org/ 10.1155/2013/151432.
30. Eman AA, Soumyajit M, Abdulla A, Sultan A, Bader A, Xin F, et al. Hot melt extrusion as an approach to improve solubility, permeability, and oral absorption of a psychoactive natural product, piperine. J Pharm Pharmacol 2016;68:989–98.
31. Hong W, Huijeong J, Xuhong L. Drug delivery approaches in addressing clinical pharmacology-related issues: opportunities and challenges. AAPS 2015;17:1327-40.
32. Smith T, Kawa K, Eckl V, Johnson J. Sales of herbal dietary supplements in US increased 7.5% in 2015 consumers spent $6.92 billion on herbal supplements in 2015, marking the 12th consecutive year of growth. Am Botanical Council Herbal Gram 2016;111:67-73.
33. Shephard A, Zybeshari S. Virucidal action of sore throat lozenges against respiratory viruses parainfluenza type 3 and cytomegalovirus. Antiviral Res 2015;123:158-62.
34. Tan TW, Chen BC, Tan HL, Chang CM. Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol. JBI Database System Rev Implement Rep 2017;15:862-72.
35. Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A. A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza a and SARS-CoV. Antivir Chem Chemother 2005;16:129-34.
36. Wade AG, Morris C, Shephard A, Crawford GM, Goulder MA. A multicentre, randomised, double-blind, single-dose study assessing the efficacy of AMC/DCBA warm lozenge or AMC/DCBA cool lozenge in the relief of acute sore throat. BMC Fam Pract 2011;12:6.
37. Michael SC, Kenneth R, Ross WB, Maurice IM, Denis JM. Absorption of orally administered amphotericin B lozenges. Br J Clin Pharmac 1983;16:106-8.
38. Vries Hosper HG, Mulder NH, Sleijfer DT, Van Saene HK. The effect of amphotericin B lozenges on the presence and number of Candida cells in the oropharynx of neutropenic leukemia patients. Infection 1982;10:71-5.
39. Nagoba SN, Purushotham RK, Zakaullah S. Formulation of clotrimazole as lozenge tablet for improved delivery to oral thrush. JPBMS 2011;12:1-4.
40. Neha D, Aparna C, Prathima S. Formulation and evaluation of medicated lozenges of albendazole for paediatric use. Asian J Biochem Pharm Res 2015;5:202-15.
41. Purushotham RK, Shivappa NN, Vishwanath R, Ayshiya SA, Zakaullah S, Ashok KC, et al. Medicated lollipops for the treatment of oral thrush in children. Int J Life Sci Btand Pharm Res 2012;1:95-102.
42. Michel C, Salvatico S, Belkhelfa H, Haddioui L, Roques C. Activity of Drill®lozenges on the main microorganisms responsible for upper respiratory tract infections. Eur Ann Otorhinolaryngol Head Neck Dis 2013;130:189-93.
43. Palm J, Fuchs K, Stammer H, Stimpfl AS, Milde J. Efficacy and safety of a triple active sore throat lozenge in the treatment of patients with acute pharyngitis: results of a multi?centre, randomised, placebo?controlled, double?blind, parallel?group trial (DoriPha). Int J Clin Pract 2018;72:e13272.
44. Caruso TJ, Prober CG, Gwaltney JM. Treatment of naturally acquired common colds with zinc: a structured review. Clin Infect Dis 2007;45:569-74.
45. Garland ML, Hagmeyer KO. The role of zinc lozenges in treatment of the common cold. Ann Pharmacother 1998;32:63-9.
46. Eby GA. Zinc lozenges as cure for the common cold--a review and hypothesis. Med Hypotheses 2010;74:482-92.
47. Harri H, Elizabeth C. The effectiveness of high dose zinc acetate lozenges on various common cold symptoms: a meta-analysis. BMC Fam Pract 2015;16:24.
48. Mossad SB, Macknin ML, Medendorp SV, Mason P. Zinc gluconate lozenges for treating the common cold. A randomized, double-blind, placebo-controlled study. Ann Intern Med 1996;15125:81-8.
49. Ndindayino F, Vervaet C, Van den MG, Remon JP. Bioavailability of hydrochlorothiazide from isomalt-based moulded tablets. Int J Pharm 2002;246:199-202.
50. Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das, K Purushotham Rao. Design and evaluation of nimesulide lozenges for pediatrics. Res J Pharm Tech 2010;3:818-20.
51. Akansha Bhandarkar, Amit Alexander, Aditi Bhatt, Pankaj Sahu, Palak Agrawal, Tripti Banjare, et al. Formulation and evaluation of ascorbic acid lozenges for the treatment of oral ulcer. Res J Pharm Tech 2018;11:1307-12.
52. Campus G, Cocco F, Carta G, Cagetti MG, Simark Mattson C, Strohmenger L, et al. Effect of a daily dose of Lactobacillus brevis CD2 lozenges in high caries risk schoolchildren. Clin Oral Invest 2014;18:555–61.
53. Vito T, Stefano DC, Maurizio B, Antonella P. Use of lozenges containing Lactobacillus brevis CD2 in recurrent aphthous stomatitis: a double-blind placebo-controlled trial. Hindawi Publishing Corporation Ulcers 2011;439425:1-6.
54. Litty S, Nagarathna DV, Merline V. Probiotics in periodontal therapy. Int J Pharm Bio Sci 2015;6:242-50.
55. Teughels W, Durukan A, Ozcelik O, Pauwels M, Quirynen M, Haytac MC. Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol 2013;40:1025-35.
56. Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers. W Dimpfel, Pischel, R Lehnfeld. Eur J Med Res 2004;9:423-31.
57. Hina Rehman, Syed Adnan Ali, Safila Naveed, Khan Usmanghani. An interquartile relationship between polyherbal extract based lozenges linkus a phase IV comparative randomised control trial. Pak J Pharm Sci 2017;(3 Suppl):961-6.
58. Chu Hong Hu, Jian He, Randal Eckert, Xiao Yang Wu, Li-Na Li, Yan Tian, et al. Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria. Int J Oral Sci 2011;3:13-20.
59. MC Peters, JA Tallman, TM Braun, JJ Jacobson. Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study. Eur Arch Paediatr Dent 2010;11:274-8.
60. Merve Erkmen Almaz, Is?l Saroglu Sonmez, Zeynep Okte, Aylin Akbay Oba. Efficacy of a sugar-free herbal lollipop for reducing salivary Streptococcus mutans levels: a randomized controlled trial. Clin Oral Investig 2017;21:839-45.
61. Yandi Chen, Melissa Agnello, Marcia Dinis Kenneth C Chien, Jing Wang, Wei Hu, Wenyuan Shi, et al. Lollipop containing Glycyrrhiza uralensis extract reduces streptococcus mutans colonization and maintains oral microbial diversity in Chinese preschool children. PLoS One 2019;14:e0221756.
62. Otis LB, Gregory F, Martin AJ, James MS. Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: proof of concept. Plos One 2014;9:e90131.
63. Vinay KH, Aditee RS, Sindhu MG. Efficacy of curcumin in the treatment for oral submucous fibrosis-a randomized clinical trial. J Oral Maxillofac Pathol 2015;19:145-52.
64. Manayi A, Vazirian M, Saeidnia S. Echinacea purpurea: pharmacology, phytochemistry and analysis methods. Pharmacogn Rev 2015;9:63-72.
65. Schapowal A, Berger D, Klein P, Suter A. Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial. Eur J Med Res 2009;14:406-12.
66. Guiotto P, Woelkart K, Grabnar I, Voinovich D, Perissutti B, Invernizzi S, et al. Pharmacokinetics and immunomodulatory effects of phytotherapeutic lozenges (bonbons) with Echinacea purpurea extract. Phytomed 2008;15:547-54.
67. Lone H, Gro CH, Hedvig N. Echinacea and Elderberry-should they be used against upper respiratory tract infections during pregnancy? Front Pharmacol 2014;5:31.
68. Alka D, Raman D, Yogesh KS. Exploration of phytochemicals found in Terminalia sp. and their antiretroviral activities. Pharmacogn Rev 2016;10:73-83.
69. Zakay Rones Z, Thom E, Wollan T, Wadstein J. Randomized study of the efficacy and safety of oral Elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res 2004;32:132-40.
70. Tiralongo E, Wee SS, Lea R. Elderberry supplementation reduces cold duration and symptoms in air-travellers: a randomized, double-blind placebo-controlled clinical trial. Nutrients 2016;8:182.
71. Benbassat N, Kostova B, Nikolova I, Rachev D. Development and evaluation of novel lozenges containing marshmallow root extract. Pak J Pharm Sci 2013;26:1103-7.
72. White MR, Helmerhorst EJ, Ligtenberg A, Karpel M, Tecle T, Siqueira WL, et al. Multiple components contribute to ability of saliva to inhibit influenza viruses. Oral Microbiol Immunol 2009;24:1.
73. Malamud D, Abrams WR, Barber CA, Weissman D, Rehtanz M, Golub E. Antiviral activities in human saliva. Adv Dent Res 2011;23:34–7.
74. Fabian TK, Hermann P, Beck A, Fejerdy P, Fabian G. Salivary defense proteins: their network and role in innate and acquired oral immunity. Int J Mol Sci 2012;13:4295-320.
75. Luzzi R, Belcaro G, Pellegrini L, Cornelli U, Feragalli B, Dugall M. Phyto-relief CC: prevention of cold episodes. Control of signs/symptoms and complications. Minerva Gastroenterol Dietol; 2015.
76. Safinaz D, Soekanto SA, Sarwono AT. The effects of propolis honey candy consumption on myeloperoxidase activity in stimulated saliva. Int J Appl Pharm 2019;11:137-40.
77. Wijaya KM, Soekanto SA, Soedarsono N. Effect of honey propolis hard candy on lactoperoxidase activity in unstimulated saliva. Int J Appl Pharm 2019;11:103-5.
78. Khodijah K, Farida R, Soedarsono N. The effect of propolis extract and propolis candies on the growth of Aggregatibacter actinomycetemcomitans ATCC 43718. Asian J Pharm Clin Res 2017;10:26-9.
79. Anand K, Lakshmy R, Janakarajan VN, Ritvik A, Misra P, Pandey RM, et al. Effect of consumption of micronutrient fortified candies on the iron and vitamin a status of children aged 3-6 y in rural Haryana. Indian Pediatr 2007;44:823-9.
80. Medeiros Neves B, Nemitz MC, Nathiely F, Fachel S, Teixeira HF. Recent patents concerning the use of nanotechnology-based delivery systems as skin penetration enhancers. Recent Pat Drug Delivery Formul 2019;13:192–202.
81. Kirsty Sawicka, Jasmine Takhar, Paul Marshall, Michael Fanfarillo. Production process for NSAID-containing lozenges, their compositions, their medicinal use. US20190307711A1. Reckitt Benckiser Healthcare UK Ltd; 2019.
82. John C Godfrey. Combination of zinc ions and vitamin C and method of making. US6316008B1; 2018.
83. Bharat Pravinchandra Mehta, Rajen Dhirubhai Shah, Manoj Kantilal Patel, Parmeshwar B Bang. Nicotine containing formulation. J B Chemicals and Pharmaceuticals Ltd US20120244104A1; 2012.
84. Graham H. Brown, USPTO6082368, Nicotine candy cigarette; 2000.
85. Gian Carlo Santus, Nicotine lozenge, McNeil AB Pharmacia AB. US6280761B1; 2001.
86. Thomas S Ells, Joseph R Luber. Process for making a hard-candy based oral pharmaceutical lozenge containing an antacid. Johnson and Johnson Consumer Inc US5616340A; 1997.
87. Henryk Jakubowski. Teeth whitening candy with tartar removal and breath freshening properties, Jakubowski Henryk P, US20060210488A1; 2006.
88. Kaushik P, Kaushik D. Medicated chewing gums: recent patents and patented technology platforms. Recent Pat Drug Delivery Formul 2019;13:184-91.
89. Laurence C Chow, Shozo Takagi, Gerald L Vogel. Anti-carious chewing gums, candies, gels, toothpastes and dentifrices. American Dental Association Health Foundation USPTO 5993786; 1999.
90. Brown Bruce A, Lane Philip A. Anaesthetic lozenges and method of preparing them. Beecham Inc. EP0001907A1; 1981.
91. Kay OD, Malcolm WK. Sweeteners and sugar alternatives in food technology. 2ndedn. Wiley-Blackwell, A John Wiley and Sons, Ltd; 2012. p. 79.
92. Serpelloni Michel, Ribadeau Dumas Guillaume. Sugar based hard boiled sweets and process for it manufacture. US5601866; 1997.
93. Serpelloni Michel, Ribadeau Dumas Guillaume. Sugar-free hard boiled candy and process for its manufacture. US5629042; 1997.
94. Richard WH, Joachim HE, Randy H. Physico-chemical properties of sweeteners in confections. Confectionery Science and Technology; 2017. p. 39-67.
95. Leon Mentink, Michel Serpelloni. Sugar-free “hard candy” and process for its manufacture. US514701; 1994.
96. Ergun R, Lietha R, Hartel RW. Moisture and shelf life in sugar confections. Crit Rev Food Sci Nutr 2010;50:162-92.
97. Irena S, Jana C, Martin M. Crystals in Hard candies. Czech J Food Sci 2003;21:185-91.
98. Richard WH, Roja E, Sarah V. Phase/State transitions of confectionery sweeteners: thermodynamic and kinetic aspects. Compr Rev Food Sci Food Saf 2011;10:17-32.
99. Wadesango L, Nxumalo N, Schellack N. An overview of throat lozenges and sprays in the management of pharyngitis at primary care level. S Afr Pharm J 2019;86:17-20.
100. Muhammad I, Sumeira R, Quratulain B, Muhammad IQ, Farhat J, Ahmed K. Orally disintegrating films: a modern expansion in drug delivery system, Saudi Pharm J 2016;24:537-46.
101. Ells Thomas S, Luber Joseph R. Process for making a hard-candy based oral pharmaceutical lozenge containing an antacid. United States Patent,5,616,340; 1997.
102. Pinney John M, Henningfield, Jack E, Cone, Edward J. Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements. United States Patent Application 20060073189; 2006.
103. Milchel S, Les B, Guillaaume RD. Sugar-based hard boiled sweet and process for its manufacture. USP5601866; 1997.
104. Ergun R, Lietha R, Hartel RW. Moisture and shelf life in sugar confections. Crit Rev Food Sci Nutr 2010;50:162–92.
105. Eckert C, Lutz C, Breitkreitz J, Woertz K. Quality control of oral herbal products by an electronic tongue-case study on sage lozenges. Sens Actuators B Chem 2011;156:204-12.
106. Md SU, Abdullah AM, Tanjuma T, Md A. Journal of in-process and finished products quality control tests for pharmaceutical tablets according to pharmacopoeias. J Chem Pharm Res 2015;7:180-5.
107. Uddin MS, Abdullah AM, MdSH, MdA, MdSS, Mamunur R, et al. In vitro quality evaluation of leading brands of ciprofloxacin tablets available in Bangladesh. BMC Res Notes 2017;10:185-94.
108. Milz B, Spangenberg B. A validated quantification of benzocaine in lozenges using TLC and a flatbed scanner. Chromatographia 2013;76:1307-13.
109. Alqurshi A, Kumar Z, McDonald R, Strang J, Buanz A, Ahmed S, et al. Amorphous formulation and in vitro performance testing of instantly disintegrating buccal tablets for the emergency delivery of naloxone. Mol Pharmaceutics 2016;13:1688-98.
110. Pinto S, Manuela E, Pintado ME, Sarmento B. In vivo, in vitro and ex vivo assessment of buccal permeation of drugs from delivery systems. Expert Opin Drug Delivery 2019;17:33-48.
111. Wang S, Zuo A, Guo J. Types and evaluation of in vitro penetration models for buccal mucosal delivery. J Drug Delivery Sci Technol 2020. https://doi.org/10.1016/j.jddst.2020.102122
112. Yingyi M, David JM. Influence of electrostatic heteroaggregation of lipid droplets on their stability and digestibility under simulated gastrointestinal conditions. Food Funct 2012;3:1025-34.
113. Agrawal AM, Dudhedia MS, Zimny E. Hot melt extrusion: development of an amorphous solid dispersion for an insoluble drug from mini-scale to clinical scale. AAPS PharmSciTech 2016;17:133-47.
114. Patil H, Tiwari RV, Repka MA. Hot-melt extrusion: from theory to application in pharmaceutical formulation. AAPS PharmSciTech 2016;17:20-42.
115. Zhao X, Chen Q, Liu W, Li Y, Tang H, Liu X, et al. Codelivery of doxorubicin and curcumin with lipid nanoparticles results in improved efficacy of chemotherapy in liver cancer. Int J Nanomed 2015;10:257-70.
116. Mirza S, Miroshnyk I, Habib MJ, Brausch JF, Hussain MD. Enhanced dissolution and oral bioavailability of piroxicam formulations: modulating effect of phospholipids. Pharmaceutics 2010;2:339-50.
117. Hu L, Shi Y, Li JH, Gao N, Ji J, Niu F, et al. Enhancement of oral bioavailability of curcumin by a novel solid dispersion system. AAPS PharmSciTech 2015;16:1327-34.
118. Singh K, Sharma S. Development and characterization of orodispersible tablets of propranolol hydrochloride using calcium cross-linked cassia fistula gum and cross carmellose sodium. Int J Appl Pharm 2020;12:160-9.
119. Anita K, Matjaz K, Primoz S, Janez P. Potential of solid-state NMR and SEM in characterization of tablets of ibuprofen. Curr Pharma Anal 2015;11:124-30.
120. Rewanthwar SL, Lakshmi PK. Electronic tongue: an analytical gustatory tool. J Adv Pharm Technol Res 2012;3:3-8.
121. Abu Khalaf N, Zaid AN, Jaradat N, Alkilany A, Abu Rumaila B, Al Ramahi R, et al. The taste of commercially available clarithromycin oral pharmaceutical suspensions in the palestinian market: electronic tongue and in vivo evaluation. Sensors 2018;18:E454.
122. Carolin E, Miriam P, Jurg R, Jorg B. Taste evaluation of multicomponent mixtures using a human taste panel, electronic taste sensing systems and HPLC. Sens Actuators B Chem 2013;182:294-9.
123. Carolin E, Christina L, Jorg B, Katharina W. Quality control of oral herbal products by an electronic tongue-case study on sage lozenges. Sens Actuators B Chem 2011;156:204-12.
124. Sharifzadeh A, Hajsharifi Shahreza M, Ghasemi Dehkordi P. Evaluation of microbial contamination and chemical qualities of cream-filled pastries in confectioneries of chaharmahal va bakhtiari province (Southwestern Iran). Osong Public Health Res Perspect 2016;7:346-50.
125. Carminati JD, Amorim Neto DP, Morishita KN, Takano LV, Olivier BA, Copetti MV, et al. Microbiological contamination in peanut confectionery processing plants. J Appl Microbiol 2016;121:1071-8.
126. Govt. of India, Ministry of health and family welfare, Department of Ayurveda, Naturopathy, Unani, siddha (AYUSH), Part-II. Vol-III. 1st Ed Ayurvedic pharmacopoeia of India: New Delhi; 2010.
127. Yuan X, Chapman RL, Wu Z. Analytical methods for heavy metals in herbal medicines. Phytochem Anal 2011;22:189-98.
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SAHOO, M. R., UMASHANKAR, M. S., & VARIER, R. R. (2021). THE RESEARCH UPDATES AND PROSPECTS OF HERBAL HARD-BOILED LOZENGES: A CLASSICAL PLATFORM WITH PROMISING DRUG DELIVERY POTENTIAL. International Journal of Applied Pharmaceutics, 13(2), 1-13. https://doi.org/10.22159/ijap.2021v13i2.40165
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