NIOSOMES AS AN APPROACH TO IMPROVE THE SOLUBILITY AND BIOAVAILABILITY OF BCS CLASS II DRUGS

Abstract

The drugs which are discovered are divided into four classes according to the Biopharmaceutics classification system such as (BCS) Class I, II, III, and IV based on their solubility and permeability. Out of this, the BCS class II drugs having low solubility and high permeability need methods to improve their solubility as this is their rate-limiting step. Such methods include lipid carriers such as liposomes, niosomes, aquasomes, etc., and other approaches including Self Micro Emulsifying Drug Delivery Systems (SMEDDS), Self-Nano Emulsifying Drug Delivery Systems (SNEDDS), and so forth. Nowadays Niosomes have become a popular Drug Delivery system utilizing non-ionic surfactants, drugs, and cholesterol in varying ratios to deliver both hydrophilic as well as Lipophilic Drugs and having many applications