DERMATOLOGIC GELS SPREADABILITY MEASURING METHODS COMPARATIVE STUDY

Authors

  • BAKHRUSHINA ELENA O. Sechenov First State Medical University, Russia 119991, Moscow, Trubetskaya ST., 8
  • ANUROVA MARIA N. Sechenov First State Medical University, Russia 119991, Moscow, Trubetskaya ST., 8
  • ZAVALNIY MICHAEL S. Sechenov First State Medical University, Russia 119991, Moscow, Trubetskaya ST., 8
  • DEMINA NATALIA B. Sechenov First State Medical University, Russia 119991, Moscow, Trubetskaya ST., 8
  • BARDAKOV ALEXANDER I. Sechenov First State Medical University, Russia 119991, Moscow, Trubetskaya ST., 8
  • KRASNYUK IVAN I. Sechenov First State Medical University, Russia 119991, Moscow, Trubetskaya ST., 8

DOI:

https://doi.org/10.22159/ijap.2022v14i1.41267

Keywords:

dermatological gels, gels, parallel plate method, rotational viscometry, slip and dra method, spreadability

Abstract

Objective. The main objective of our study is the comprehensive analysis and characterization of the existing spreadability evaluation strategies, the comparison of the obtained results reproducibility and convergence through the example of the 9 most widely used dermatological gels.

Methods. Dolobene®, Flucinar®, Ketorol®, Contractubex®, Dr. Theiss Venen gel®, Solcoseryl®, Deep Relief®, Hepatrombin® pharmacopoeia gel samples were analyzed using parallel-plate, “slip and drag”, and viscometry methods. Analysis was performed in flow mode at 32 ± 0.2 °C, over shear rates ranging from 0 to 350 s−1, increasing over a period of 120 s, and was maintained at the superior limit for 10 s and then decreased during the same period. At least 5 replicates of each sample were evaluated, and the upward flow curves were fitted using the Casson mathematical model.

Results. Solcoseryl® and Dolobene® showed the best spreadability in the parallel-plate method (3115.66±50.00 and 3316.63±50.00, respectively); Contractubex® and Dolobene showed the best spreadability in the “slip and drag” test (73.46±0.5 and 18.32±0.5, respectively); Solcoseryl® and Contractubex® showed the best spreadability in the viscometry test (43.86±0.5 and 76.92±0.5, respectively).

Conclusion. This study analyzed the existing methods for determining the spreadability using commercially available samples of the dermatological gels as examples. The viscometric and the "Slip and drag" methods use different characteristics of spreadability, giving a complex evaluation of the measured parameter in vitro. Therefore, the combination of these two methods has the greatest prospects for reliable determination of this indicator.

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References

Barsukova YuN, Melnikova OA. Soft Medical Form with Nanoparticles to Stop Bleeding: Substantiation of Composition and Technology of Obtaining. Drug development & registration 2019.

Barry BW, Grace AJ. Sensory Testing of Spreadability: Investigation of the Rheological Conditions Operative During the Application of Topical Preparations. J Pharm Sci 1972.

Barry BW, Meyer MC. Sensory Assessment of Spreadability of Hydrophilic Topical Preparations. J Pharm Sci 1972.

Keller T, Zulliger HW, Niederer R. Simple Model for Measuring Spreadability of Suppository Bases. Acta Pharm Technol 1982.

Hadi IA, Ugrine HE, Farouk AM, Shayoub M. Formulation of Polyethylene Glycol Ointment Bases Suitable for Tropical and Subtropical Climates. Acta Pharm Hung 1989.

Vennat B, Gross D, Pourrat A. Hydrogels Based on Cellulose Derivatives: Validation of the Spreading Diameter Measurement. STP Pharma Sci 1994.

Maru AD, Lahoti SR. Formulation and evaluation of moisturizing cream containing sunflower wax. International Journal of Pharmacy and Pharmaceutical Sciences 2018.

Ayoub AM, Ibrahim MM, Abdallah MH, Mahdy MA. Intranasal microemulgel as surrogate carrier to enhance low oral bioavailability of sulpiride. International Journal of Pharmacy and Pharmaceutical Sciences 2016.

El- Leithy ES, Makky AM, Khattab AM, Hussein DG. Nanoemulsion gel of nutraceutical co-enzyme q10 as an alternative to conventional topical delivery system to enhance skin permeability and anti-wrinkle efficiency. International Journal of Pharmacy and Pharmaceutical Sciences 2017.

Demina NB., Bakhrushina EO., Krasnyuk II., Korneev MB. The influence of the excipients on the anti-inflammatory emulgel biopharmaceutical quality parameters. Asian Journal Pharm Clin Res 2019.

Gayatri PA, Krisnawati SM, Pratami DK, Widayati. Stability of zoledronate gel emulsion in virgin coconut oil. International Journal of Applied Pharmaceutics 2019.

De Paula IC, Ortega GG, Bassani VL, Petrovick PR. Development of Ointment Formulations Prepared with Achyrocline Satureioides Spray-Dried Extracts. Drug Dev Ind Pharm 1998.

Panigrahi L, John T, Shariff A, Rani S, Hiremath R. Formulation and Evaluation of Lincomycin HCl Gels. Ind J Pharm Sci 1997.

Dubey NK, Mishra SB, Mukerjee A, Singh A. Graphene conjugated usnic acid nano-formulation for the treatment of topical fungal infection. International Journal of Pharmacy and Pharmaceutical Sciences 2020.

DeMartine ML, Cussler EL. Predicting Subjective Spreadability, Viscosity, and Stickiness. J Pharm Sci 1975.

Aust LB, Oddo LP, Wild JE, Mills OH. The Descriptive Analysis of Skin Care Products by a Trained Panel of Judges. J Soc Cosm Chem 1987.

Anurova MN, Bakhrushina EO, Barnolitskiy GG, Krechetov SP. Justification of the Rheological Optimum in the Development of Semisolid Forms. Dental gels. Drug development & registration 2017; (2): 124-28. (In Russ.)

Chapter in a book: Malkin AY, Isaev AI. Rheology: concepts, methods, applications. ChemTec Publishing; 2012. p. 255-364.

Iglesias N, Galbis E, Valencia C, Violante de-Paz M, Juan A. Galbis Reversible pH-Sensitive Chitosan-Based Hydrogels. Influence of Dispersion Composition on Rheological Properties and Sustained Drug Delivery. Polymers (Basel). 2018 Apr; 10(4): 392. Epub 2018 Apr 1.

Qushawy M, Nasr A, Abd-Alhaseeb M, Swidan S. Design. Optimization and Characterization of a Transfersomal Gel Using Miconazole Nitrate for the Treatment of Candida Skin Infections. Pharmaceutics. 2018 Mar; 10(1): 26. Epub 2018 Feb 23.

Published

02-11-2021

How to Cite

ELENA O., B., MARIA N., A., MICHAEL S., Z., NATALIA B. , D., ALEXANDER I., B., & IVAN I., K. (2021). DERMATOLOGIC GELS SPREADABILITY MEASURING METHODS COMPARATIVE STUDY. International Journal of Applied Pharmaceutics, 14(1). https://doi.org/10.22159/ijap.2022v14i1.41267

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