FABRICATION AND CHARACTERIZATION OF FAST DISSOLVING FILMS OF ECLIPTA PROSTRATE LEAVES EXTRACT TO TREAT MOUTH ULCERS

Authors

  • MANIKIRAN S. S. Department of Pharmaceutics, Vignan Pharmacy College, Vadlamudi
  • NAGAM SANTHI PRIYA Department of Pharmaceutics, Vignan Pharmacy College, Vadlamudi
  • B. AUBINE MOLLY Acharya Nagarjuna University, Nagarjuna Nagar, Guntur
  • LAKSHMI PRASANTHI NORI Department of Pharmaceutical Sciences, Vignan’s Foundation for Science Technology and Research, Vadlamudi

DOI:

https://doi.org/10.22159/ijap.2021v13i5.41597

Keywords:

Eclipta prostrate, Extract, Oral films, Super disintegrants and mouth ulcer

Abstract

Objective: This research focused on the design of fast dissolving herbal film of Eclipta Prostrate leaves extract for mouth ulcers.

Methods: The extract of Eclipta Prostrata leaves was formulated as films by solvent casting method using various polymers viz., HPMC E5, HPMC E15, sodium alginate and PVA. The films were designed by using propylene glycol as a plasticizer, SSG as super disintegrate and honey as a sweetener. Furthermore, the films were evaluated for thickness, folding endurance, weight variation, % elongation, surface pH, % moisture uptake, % moisture loss, disintegration and in vitro drug release study.

Results: The revealed that all the films were good in appearance and had a smooth texture. Out of all ten formulations, F3 and F5 disintegrated rapidly with a disintegration time of 27 and 32 seconds. The drug release studies revealed that all the formulations had a good release profile, but the F3 formulation showed rapid release i.e. 83.57% in 4 min. The stability studies revealed that the formulations F3 and F5 were found good with non-tackiness, easily separable and disintegrated at 29 and 33 sec respectively with no appearance and drug release.

Conclusion: The research revealed that Eclipta prostrate leaves extract can be formulated into oral films for the treatment of mouth ulcers with improved bioavailability and expected patient compliance.

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References

Patel J, Patel KR, Patel NM. Review on fast dissolving film. Int J Univers Pharm Bio Sci 2013;2:149-62.

Vijaya Sri K, Rohini P, Kamalakar. Montelukast sodium oral thin films: formulation and in vitro evaluation. Asian J Pharm Clin Res 2012;5:266-70.

Subash Vijaya Kumar, Basani Gavaskar, Guru Sharani, Y Madhusudan Rao. Overview on fast dissolving films; 2010;2:29-3.

Kamalesh Upreti, Lalit Kumar, Stutie Pathak Anand, Viney Chawla. Formulation and evaluation of Mouth dissolving films of paracetamol. Int J Pharm Pharm Sci 2014;6:200-2.

Shaikh S, Shete A, Doijad R. Formulation and evalution of pharmaceutical aqueous gel of powdered guava leaves for mouth ulcer treatment. Pharma Tutor 2018;6:32-8.

Shivaji SAK, Vaibhav RV. Formulation and development of quercetin and monoammonium glycyrrhizinate loaded gel for the treatment of mouth ulcer disease. Int J Pharm Sci Res 2021;12:1789-98.

Rownak Jahan, Abdullah A, Snehali M, Mohammed R. Ethnopharmacological significance of Eclipta alba Hassk. Int Scho Res Not 2014;38:22-6.

Sivaranjani R, Ramkrishnan K. Traditional uses of medicinal plants in treating skin diseases in Nagapattinam district of Tamilnadu. Int Res J Pharm 2012;3:201-4.

Nishimura M, Matsuura K, Tsukiko T, Yamashita H, Inagaki N, Sugiyama T, et al. In vitro and in vivo characteristics of prochlorperazine oral disintegrating film. Int J Pharm 2009;368:98-102.

Mashru RC, Sutariya BC, Parikh PP. Development and evaluation of fast dissolving films of salbutamol sulphate. Drug Dev Ind Pharm 2005;31:25-4.

Patel Priti, Patel Jaymin, Patel Kaushika, Nihar Shah, Shah Shreeraj. A review on fast dissolving sublingual film. J Pharm Sci Bio Sci Res 2015;5:279-85.

Granfors MT, Backman JT, Laitila J, Pertti JN. Tizanidine is mainly metabolized by cytochrome P450 1A2 in vitro. Br J Clin Pharmacol 2004;57:349–53.

Rajini Bala, Shailesh Sharma. Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment. Bull Faculty Pharm Cairo University 2018;56:159–68.

Raghuraman S, Ravichandran V, Shaffina SH, Rajasekaran T, Benito Johason D, Sankar V. Design and evaluation of propranolol hydrochloride buccal films. East Pharm 2001;10:109-11.

Mona Nagar, Mayank Nagar, Vikram Chopra. Formulation and evaluation of mouth dissolving film of antipsychotic drug aripiprazole. Der Pharm Lett 2012;4:1221-7.

Shivani Singh, Satyam Gangwar, Garima Garg, Vipin Garg, Sharma PK. Formulation and evaluation of rapidly disintegrating film of levocetirizine hydrochloride. Der Pharm Lett 2010;2:434-9.

Priyanka Nagar, Chauhan, Mohd Yasir. Insights into polymers: film formers in mouth dissolving films. Drug Inv Today 2011;3:280-9.

Rajni Bala, Pravin Pawar, Sushi Khanna, Sandeep Arora. Orally dissolving strips: a new approach to oral drug delivery system. Int J Pharm Invest 2013;3:67-6.

Smart JD. Buccal drug delivery. Exp Open Drug Delivery 2005;2:507–17.

Kadam VS, Bharkad VB, Shete GA, Jameel A, Shendarkar GR, Jadhav SV. Formulation and evaluation of fast dissolving oral film of metoclopramide HCl. W J Pharm Pharm Sci 2008;6:2052-66.

Ramani Gade, Aparna Aynampudi, Anitha Makineni. Design and development of pravastatin sodium fast dissolving films from natural mucilage of ocimum bacilicum seeds. Int J Pharm Res Rev 2014;3:17-7.

Swamy, Shiva Kumar S. Formulation and evaluation of fast dissolving oral films of palonosetron hydrochloride using HPMC-E5. Int J Pharm Chem Sci 2015;8:23-9.

Pallavi K, Pallavi T. Formulation and evaluation of fast dissolving films of eletriptan hydrobromide. Int J Curr Pharm Res 2018;9:13-1.

Rawda Khalifa Ali, Shabaraya AR, Mohd Azharuddin. Design and evaluation of fast dissolving oral films of granisetron hydrochloride. Am J Pharm Tech Res 2012;2:590-601.

Desai P, Basu B. Design and evaluation of fast dissolving oral films of domperidone. Int Res J Pharm 2012;3:134-45.

Udayashankar AC, Nandhini M, Rajini SB, Prakash HS. Pharmacological significance of medicinal herb Eclipta alba L.-a review. Int J Pharm Sci Res 2019;1:3592-606.

Murata Y. Preparation of fast dissolving films for oral dosage form natural polysaccharides. Materials 2010: 3:4291-9.

Bhupinder B, Sarita J, Mandeep K, Harmanpreet S. Orally fast dissolving films: innovation in formulation and technology. Int J Pharm Sci Rev Res 2010;9:50-7.

Desai P, Basu B. Design and evaluation of fast dissolving oral films of domperidone. Int Res J Pharm 2012;3:134-45.

Vaishali YL, Kashmira BU. Formulation development and evaluation of fast dissolving film of telmisartan. Ind J Pharm Sci 2012;15:132-7.

Published

07-09-2021

How to Cite

S. S., M., PRIYA, N. S., MOLLY, B. A., & NORI, L. P. (2021). FABRICATION AND CHARACTERIZATION OF FAST DISSOLVING FILMS OF ECLIPTA PROSTRATE LEAVES EXTRACT TO TREAT MOUTH ULCERS. International Journal of Applied Pharmaceutics, 13(5), 263–271. https://doi.org/10.22159/ijap.2021v13i5.41597

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