• Khaled Al-tahami Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Science and Technology, Sana’a, Yemen.


Objective: Ketoprofen is a nonsteroidal anti-inflammatory drug which could benefit if fabricated in a sustained delivery system. This work aims to develop the sustained release delivery system for ketoprofen using natural polymers.

Methods: Alginate microspheres were prepared employing crosslinking method employing calcium chloride. The formation and compatibility of microspheres was confirmed by FT-IR. The formed microspheres were evaluated for percentage yield, drug content, drug loading, and encapsulation efficiency. In vitro release studies were carried out in phosphate buffer (pH 7.4).

Results: FT-IR spectra exhibited the successful compatible encapsulation of ketoprofen in alginate microsphers. The formed microspheres exhibited good drug loading and encapsulation efficiency. The drug release was sustained over a period of 8 hours. There was a better release profile in phosphate buffer in formulations containing 3:1 polymer to drug ratio.

Conclusion: It was feasible to prepare alginate-based microspheres capable of sustaining ketoprofen release over an extended period of time.

Keywords: Microspheres, Sustained release, Ketoprofen, Alginate.


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How to Cite
Al-tahami, K. (1). PREPARATION, CHARACTERIZATION, AND IN VITRO RELEASE OF KETOPROFEN LOADED ALGINATE MICROSPHERES. International Journal of Applied Pharmaceutics, 6(3), 9-12. Retrieved from
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