PREPARATION, CHARACTERIZATION, AND IN VITRO RELEASE OF KETOPROFEN LOADED ALGINATE MICROSPHERES


Khaled Al-tahami

Abstract


Objective: Ketoprofen is a nonsteroidal anti-inflammatory drug which could benefit if fabricated in a sustained delivery system. This work aims to develop the sustained release delivery system for ketoprofen using natural polymers.

Methods: Alginate microspheres were prepared employing crosslinking method employing calcium chloride. The formation and compatibility of microspheres was confirmed by FT-IR. The formed microspheres were evaluated for percentage yield, drug content, drug loading, and encapsulation efficiency. In vitro release studies were carried out in phosphate buffer (pH 7.4).

Results: FT-IR spectra exhibited the successful compatible encapsulation of ketoprofen in alginate microsphers. The formed microspheres exhibited good drug loading and encapsulation efficiency. The drug release was sustained over a period of 8 hours. There was a better release profile in phosphate buffer in formulations containing 3:1 polymer to drug ratio.

Conclusion: It was feasible to prepare alginate-based microspheres capable of sustaining ketoprofen release over an extended period of time.

Keywords: Microspheres, Sustained release, Ketoprofen, Alginate.


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References


Vyaas SP, Khur RK. Targeted and controlled drug delivery-Novel carrier systems. Delhi: CBS publishers and distributers; 2006.

Kronenthal RL. Biodegradable polymers in medicine and surgery. In: Kronenthal RL, Oser Z, Martin E,editors. Polymers in medicine and surgery. New York: Plenum Press; 1975.

Vasir JK, Tambwekar K, Garg S. Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm 2003;255:13-32.

Kim CK, Lee EJ. The controlled release of blue dextran from alginate beads. Int J Pharm 1992;79:11-9.

Fossgreen J, Kirchheiner B, Petersen FO, Tophoj E, Zachariae E. Clinical evaluation of ketoprofen in rheumatoid arthritis-double blind cross over comparison with indomethacin. Scand J Rheumatol Suppl 1976;14:93.

Hilgendorf C, Spahn LH, Regardh CG, Lipka E. Caco-2 versus caco-2/HT29-MTX cocultured cell lines: permeabilities via diffusion, insideand outside-directed carrier-mediated transport. J Pharm Sci 2000;89:63.

Fattah DJ, Grant KE, Gabar Meshali MM. Physical characteristics and Release behaviour o salbutamol sulfate Beads prepared with different Ionic polysaccharides. Drug DevInd Pharm 1998;24:541-7.

Bert O, Haglund, Satyanaranayana M, Steven HN, Michel A. Preparation and evaluation of sustained release agarose beads containing ibuprofen and indomethacin. Control Drug Develop Ind Pharm 1994:20:947-57.

Tafaghodi M, Sajadi Tabasi SA, Jaafari MR. Formulation and characterization and release studies of alginate microsphere encapsulated with tetanus toxoid. J Biomat Sci Polymer Ed 2006;17:909-24.

Venkatesan P, Manavalan R, Valliappan K. Preparation and evaluation of sustained release loxoprofen loaded microspheres. J Basic Clin Pharm 2011;2:159.

Chou, WH, Tsai TR, Hsu SH, Cham TM. Preparation and in-vitro evaluation of nifedipin-loaded albumin microspheres cross-linked by different glutaraldehyde concentrations. Int J Pharm 1996;144:241-5.

Sudhamani T, Noveenkumarreddy K, Ravi Kumar VR, Revathi R, Ganesan V. Preparation and evaluation of ethyl cellulose microspheres of ibuprofen for sustained drug delivery. Int J Pharm Res Dev 2010;1:119-25.

Sanghvi SP, Nairn JG. Effect of viscosity and interfacial tension on particle size of cellulose acetate trimellitate microspheres. J Microencapsulation 1992;9:215-27.

Perumal D. Microencapsulation of ibuprofen &Eudragit RS 100 by the emulsion solvent diffusion technique. Int J Pharm 2001;218:1-11.

Kilicarslan M, Baykara T. The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres. Int J Pharm 2003;252:99-109.

Gibaud S, Bonneville A, Astier A. Preparation of 3, 4-diaminopyridinemicroparticles by solvent-evaporation methods. Int J Pharm 2002;242:197-201.

Venkatesan P, Muralidharan C, Manavalan R, Valliappan K. Selection of better method for the preparation of microspheres by applying analytic hierarchy process. J Pharm Sci Res 2009;1:64-78.

Sahin S, Selek H, Ponchel G, Ercan MT, Sargon M, Hincal AA, Kas HS. Preparation, characterization and in-vivo distribution of terbutaline sulfate loaded albumin microspheres. J Cont Rel 2002;82:345-58.




About this article

Title

PREPARATION, CHARACTERIZATION, AND IN VITRO RELEASE OF KETOPROFEN LOADED ALGINATE MICROSPHERES

Date

01-11-2014

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 6, Issue 3 (Oct-Dec 2014) Page: 9-12

Online ISSN

0975-7058

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412 Views | 169 Downloads

Authors & Affiliations

Khaled Al-tahami
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Science and Technology, Sana’a, Yemen.


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