INHIBITION OF GASTRIC DEGRADATION OF OMEPRAZOLE USING A pH-SENSITIVE POLYMER AS A BINDER IN TABLET FORMULATION
Keywords:Afzelia gum, pH-sensitive, Gastric degradation, Omeprazole
Objective: This work was aimed at formulating omeprazole tablets using afzelia gum as a binder that is capable of inhibiting the gastric degradation of the drug.
Methods: Afzelia gum at different concentrations of 0, 5, 10, 15, 20 and 30% was used as a binder to formulate omeprazole tablets. The tablets were formulated by direct compression and the batches labelled F1 to F6 respectively. A batch containing 15% hydroxypropyl methylcellulose (F7) was also formulated. The tablets were characterized; and dissolution in a pH 1.2 dissolution medium over 120 min period was studied. Aliquots taken every 20 min were analyzed by ultraviolet spectrophotometry to determine the amount of drug released and not degraded.
Results: Amounts of drug released and not degraded at time 120 min were 53.1%, 57.3%, 57.8%, 58.8%, 62.1%, 83.4% and 90.0% for F1 to F7 respectively.
Conclusion: Afzelia gum at a concentration of 30% is suitable for use as a binder in tablet formulation of omeprazole to ensure substantial inhibition of gastric degradation of the drug.
Kallen BAJ. Use of omeprazole during pregnancy–no hazard demonstrated in 955 infants exposed during pregnancy. Eur J Obst Gyn Reprod Biol 1999;96:63-8.
Gul W, Sajid S, Hamid F, Bhatti S. Effect of acidic pH and heat on the degradation of omeprazole and esomeprazole. Pharma Innov J 2015;4:19-21.
DiGiacinto JL, Olsen KM, Bergman KL, Hoie EB. Stability of suspension formulations of lansoprazole and omeprazole stored in amber-colored plastic oral syringes. Annals Pharmacother 2000;34:600-5.
El-Sayed E, Boraie NA, Ismail FA, El-Khardagui LK, Khalil SA. Assessment of the pharmaceutical quality of omeprazole capsule brands marketed in Egypt. Eastern J 2007;13:1427-37.
Olorunsola EO, Bhatia PG, Tytler BA, Adikwu MU. Some chemical characteristics of novel hemicellulosic gums from seeds of Afzelia africana and Prosopis africana. West Afr J Pharm 2014;25:31-40.
Park YB, Cosgrove DJ. Xyloglucan and its interactions with other components of the growing cell wall. Plant Cell Physiol 2015;56:180-94.
Sun XF, Wang HH, Jing ZX, Mohanathas R. Hemicellulose-based pH-sensitive and biodegradable hydrogel for controlled drug delivery. Carbohydrate Polym 2013;92:1357-66.
Builders PF, Chukwu C, Obidike I, Builders MI, Attama AA, Adikwu MU. A novel xyloglucan gum from seeds of Afzelia africana Se. Pers.: some functional and physicochemical properties. Int J Green Pharm 2009;3:112-8.
Olorunsola EO, Isah AB, Allagh TS. Compression and mechanical properties of microcrystalline sweet potato starch. Nig J Pharm Sci 2014;13:5-11.
Coutts RT. Infrared spectroscopy. In: Chatten LG. editor. Pharmaceutical chemistry-instrumental techniques. New Delhi India: CBS Publishers and Distributors PVT Ltd; 2008. p. 59–125.
Hashemi HMB, Al-Amoudi SBO. A review on the angle of repose of granular materials. Powd Technol 2018;330:397-417.
Reus Medina M, Lanz M, Kumar V, Leuenberger H. Comparative evaluation of the powder properties and compression behaviour of a new cellulose-based direct compression excipient and Avicel PH-102. J Pharm Pharmacol 2004;56:951-6.
Bose V, Sree R. Design and development of gastroretentive drug delivery system of ciprofloxacin hydrochloride. Asian J Pharm Clin Res 2018;11:141-6.
Nascimento NCDO, Boldo EM. Evaluation of mechanical strength after compression of metformin 500 mg tablets formed by different wet routes. Int J Pharm Pharm Sci 2021;13:30-4.
Juppo AM. Relationship between breaking force and pore structure of lactose, glucose and mannitol tablets. Int J Pharm 1996;127:95-102.
Ashford M. Gastrointestinal tract-physiology and absorption. In: Aulton ME. editor. Aulton’s Pharmaceutics: The design and manufacture of medicine. 3rd edition. Hungary: Churchill Livingstone Elsevier; 2007. p. 270-85.
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Copyright (c) 2021 Emmanuel Oluwatoyin Olorunsola, Stephen O. Majekodunmi, Iniobong J. Odiong
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