LONG-TERM IMMUNOLOGICAL CONSEQUENCES OF COVID-19 ON HEALTH
SARS-Cov-2 (severe acute respiratory syndrome coronavirus) that initially came to notice in December 2019 is the agent responsible for COVID-19 is still spreading rapidly worldwide and it is presently a potent danger to the world and also to the economy. Patients with COVID-19 are still at risk of Acute Respiratory Distress Syndrome (ARDS), respiratory failure, and death. Those patients whose aged more than sixty years with comorbidities, children, and healthcare workers are highly vulnerable to this virus patient shows various symptoms most commonly cough, fever, difficulty in breathing, fatigue, sore throat. The infection could be categorized into three stages: mild infection, the pulmonary stage, and the inflammatory stage. As the COVID-19 pandemic continues, it has been clear that infection caused due to SARS-Cov-2 might be responsible for the unpredicted long-term health consequences. In addition to this, it has acute respiratory manifestations, adversely SARS-Cov-2 also affects the other organ systems. However, there is limited to the management of COVID-19 related conditions of the extrapulmonary systems. After recovery, patients remain at risk for lung disease, heart disease, and mental ailment. There may be long-term consequences of adverse effects they observed in the course of COVID-19 and during its treatment. This review provided information about the extrapulmonary manifestations of COVID-19 that may impair the urinary, cardiovascular, gastrointestinal, hematological, hematopoietic, neurological, or reproductive systems. Also, the main purpose of this article is to describe the current concern of the extrapulmonary complications that were caused due to COVID-19 and also to improve the management and diagnosis of these patients.
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia. New England Journal of Medicine 2020;382:1199-1207.
Zhang C, Shi L, Wang F. Liver injury in COVID-19: management and challenges. The Lancet Gastroenterology & Hepatology 2020;5:428-30.
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine 2020;382:727-33.
Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nature Microbiology 2020;5:562-69.
Rodríguez‐Puertas R. ACE2 activators for the treatment of COVID 19 patients. Journal of Medical Virology 2020;92:1701-2.
Gurwitz D. Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics. Drug Development Research 2020;81:537-40.
Gibson P, Qin L, Puah S. COVID ‐19 acute respiratory distress syndrome ( ARDS ): clinical features and differences from typical pre‐ COVID ‐19 ARDS. Medical Journal of Australia 2020;213:54.
Cuykx M, Mortelé O, Jansens H, Schouwers S, Meskal A, Hoffbauer I et al. Serological response in health care workers after a single dose of SARS-CoV-2 vaccine using six automated SARS-CoV-2 antibody assays. Diagnostic Microbiology and Infectious Disease 2021;101:115486.
Jia H, Look D, Shi L, Hickey M, Pewe L, Netland J et al. ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia. Journal of Virology 2005;79:14614-21.
Rezaei N. COVID-19 affects healthy pediatricians more than pediatric patients. Infection Control & Hospital Epidemiology 2020;41:1106-7.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet 2020;395:507-13.
Al-Tawfiq J, Al-Homoud A, Memish Z. Remdesivir as a possible therapeutic option for the COVID-19. Travel Medicine and Infectious Disease 2020;34:101615.
Kapoor K, Sanawedwala A, Rajput D, Bhardwaj S, Shrivastav K, Dhingra N. Current Drug Repurposing Strategies in Treatment ofCOVID-19. International Journal of ChemTech Research 2020;13:125-131.
Mitjà O, Clotet B. Use of antiviral drugs to reduce COVID-19 transmission. The Lancet Global Health 2020;8:e639-e640.
Gautret P, Lagier J, Parola P, Hoang V, Meddeb L, Mailhe M et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents 2020;56:105949.
Jaffe S. Regulators split on antimalarials for COVID-19. The Lancet 2020;395:1179.
Touret F, de Lamballerie X. Of chloroquine and COVID-19. Antiviral Research 2020;177:104762.
Zhang W, Zhao Y, Zhang F, Wang Q, Li T, Liu Z et al. The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China. Clinical Immunology 2020;214:108393.
Cao X. COVID-19: immunopathology and its implications for therapy. Nature Reviews Immunology 2020;20:269-70.
Shanmugaraj B, Malla A, Phoolcharoen W. Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development. Pathogens 2020;9:148.
Kebede T, Kumar D, Sharma P. Potential Drug Options for Treatment of COVID-19: A Review. Coronaviruses 2020;1:42-48.
Khalili J, Zhu H, Mak N, Yan Y, Zhu Y. Novel coronavirus treatment with ribavirin: Groundwork for an evaluation concerning COVID‐19. Journal of Medical Virology 2020;92:740-46.
Elfiky A. Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sciences 2020;253:117592.
Lim J, Jeon S, Shin H, Kim M, Seong Y, Lee W et al. The Author's Response: Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR. Journal of Korean Medical Science 2020;35(7).
Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A et al. Compassionate Use of Remdesivir for Patients with Severe Covid-19. New England Journal of Medicine 2020;382:2327-36.
Beigel J, Tomashek K, Dodd L, Mehta A, Zingman B, Kalil A et al. Remdesivir for the Treatment of Covid-19 — Final Report. New England Journal of Medicine 2020;383:1813-26.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA 2020;323:1061.
Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine 2020;8:475-81.
Hui D, Memish Z, Zumla A. Severe acute respiratory syndrome vs. the Middle East respiratory syndrome. Current Opinion in Pulmonary Medicine 2014;20:233-41.
Joob B, Wiwanitkit V. Novel Middle East respiratory syndrome and renal failure. Renal Failure 2013;36:147.
Shereen M, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses. Journal of Advanced Research 2020;24:91-98.
He L, Zhang Q, Li Z, Shen L, Zhang J, Wang P et al. Incorporation of Urinary Neutrophil Gelatinase-Associated Lipocalin and Computed Tomography Quantification to Predict Acute Kidney Injury and In-Hospital Death in COVID-19 Patients. Kidney Diseases 2020;1-11.
Diao B, Wang C, Wang R, Feng Z, Zhang J, Yang H et al. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection. Nature Communications. 2021;12.
Fan C, Lu W, Li K, Ding Y, Wang J. ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Infection in COVID-19 Patients. Frontiers in Medicine 2021;7.
Su H, Yang M, Wan C, Yi L, Tang F, Zhu H et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney International 2020;98:219-27.
Ronco C, Reis T. Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nature Reviews Nephrology 2020;16:308-10.
Sun D, Wang T, Zheng K, Targher G, Byrne C, Chen Y et al. Subclinical Acute Kidney Injury in COVID-19 Patients: A Retrospective Cohort Study. Nephron 2020;144:347-50.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet 2020;395:1054-62.
Yu C. Cardiovascular complications of severe acute respiratory syndrome. Postgraduate Medical Journal 2006;82:140-44.
Ruan Q, Yang K, Wang W, Jiang L, Song J. Correction to: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Medicine 2020;46:1294-97.
Yaroshchuk N, Kochmasheva V, Vakhrameev A. Cardiac complications in patients with severe COVID-19 pneumonia. Medical alphabet 2021;(5):14-17.
Ammirati E, Cipriani M, Moro C, Raineri C, Pini D, Sormani P et al. Clinical Presentation and Outcome in a Contemporary Cohort of Patients With Acute Myocarditis. Circulation 2018;138:1088-99.
Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China Life Sciences 2020;63:364-74.
Hu Y, Li Y, Jiang F, Shao T, Hu B, Zhu J et al. Efficacy and Safety of First-Line Therapeutic Drugs with Potential for the Treatment of Novel Coronavirus Pneumonia: A Meta-Analysis. SSRN Electronic Journal 2020.
Feng G, Zheng K, Yan Q, Rios R, Targher G, Byrne C et al. COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies. Journal of Clinical and Translational Hepatology 2020;8:1-7.
Gao F, Zheng K, Wang X, Yan H, Sun Q, Pan K et al. Metabolic associated fatty liver disease increases coronavirus disease 2019 disease severity in nondiabetic patients. Journal of Gastroenterology and Hepatology 2020;36:204-7.
Zhou Y, Zheng K, Wang X, Sun Q, Pan K, Wang T et al. Metabolic‐associated fatty liver disease is associated with severity of COVID‐19. Liver International 2020;40:2160-63.
Gao F, Zheng K, Fan Y, Targher G, Byrne C, Zheng M. ACE2: A Linkage for the Interplay Between COVID-19 and Decompensated Cirrhosis. American Journal of Gastroenterology 2020;115:1544.
Qi X, Liu Y, Wang J, Fallowfield J, Wang J, Li X et al. Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study. Gut 2020;gutjnl-2020:321666.
Gao F, Zheng K, Gu J, George J, Zheng M. COVID‐19 and liver transplantation: Lessons learned from three reported cases. Transplant Infectious Disease 2020;22(4).
Huang J, Zheng K, George J, Gao H, Wei R, Yan H et al. Fatal outcome in a liver transplant recipient with COVID‐19. American Journal of Transplantation 2020;20:1907-10.
Fishman J, Grossi P. Novel Coronavirus‐19 (COVID‐19) in the immunocompromised transplant recipient: #Flatteningthecurve. American Journal of Transplantation 2020;20:1765-67.
Liu B, Wang Y, Zhao Y, Shi H, Zeng F, Chen Z. Successful treatment of severe COVID‐19 pneumonia in a liver transplant recipient. American Journal of Transplantation 2020;20:1891-95.
Qin J, Wang H, Qin X, Zhang P, Zhu L, Cai J et al. Perioperative Presentation of COVID‐19 Disease in a Liver Transplant Recipient. Hepatology 2020;72:1491-93.
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurology 2020;77:683.
Herman C, Mayer K, Sarwal A. Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19. Neurology 2020;95:77-84.
Brooks S, Webster R, Smith L, Woodland L, Wessely S, Greenberg N et al. The Psychological Impact of Quarantine and How to Reduce It: Rapid Review of the Evidence. SSRN Electronic Journal 2020;.
Wu P, Fang Y, Guan Z, Fan B, Kong J, Yao Z et al. The Psychological Impact of the SARS Epidemic on Hospital Employees in China: Exposure, Risk Perception, and Altruistic Acceptance of Risk. The Canadian Journal of Psychiatry 2009;54:302-11.
Marjanovic Z, Greenglass E, Coffey S. The relevance of psychosocial variables and working conditions in predicting nurses’ coping strategies during the SARS crisis: An online questionnaire survey. International Journal of Nursing Studies 2007;44:991-98.
Wu P, Liu X, Fang Y, Fan B, Fuller C, Guan Z et al. Alcohol Abuse/Dependence Symptoms Among Hospital Employees Exposed to a SARS Outbreak: Table 1. Alcohol and Alcoholism 2008;43(6):706-12.
Jeong H, Yim H, Song Y, Ki M, Min J, Cho J et al. Mental health status of people isolated due to Middle East Respiratory Syndrome. Epidemiology and Health 2016;38:e2016048.
REYNOLDS D, GARAY J, DEAMOND S, MORAN M, GOLD W, STYRA R. Understanding, compliance and psychological impact of the SARS quarantine experience. Epidemiology and Infection 2007;136:997-7.
Hawryluck L, Gold W, Robinson S, Pogorski S, Galea S, Styra R. SARS Control and Psychological Effects of Quarantine, Toronto, Canada. Emerging Infectious Diseases 2004;10:1206-12.
Cava M, Fay K, Beanlands H, McCay E, Wignall R. The Experience of Quarantine for Individuals Affected by SARS in Toronto. Public Health Nursing 2005;22:398-406.
Maunder R, Lancee W, Balderson K, Bennett J, Borgundvaag B, Evans S et al. Long-term Psychological and Occupational Effects of Providing Hospital Healthcare during SARS Outbreak. Emerging Infectious Diseases 2006;12:1924-32.
Desclaux A, Badji D, Ndione A, Sow K. Accepted monitoring or endured quarantine? Ebola contacts' perceptions in Senegal. Social Science & Medicine 2017;178:38-45.
Gormley M, Aspray T, Kelly D. COVID-19: mitigating transmission via wastewater plumbing systems. The Lancet Global Health 2020;8:e643.
Wang Y, Zhou F, Zhang D, Zhao J, Du R, Hu Y et al. Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial. Trials 2020;21.
AH A, ST Z. Preprocessing of the Candidate Antiviral Drugs against COVID-19 in Models of SARS cov2 Targets. La Prensa Medica Argentina 2020;106.
Yao T, Qian J, Zhu W, Wang Y, Wang G. A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus—A possible reference for coronavirus disease‐19 treatment option. Journal of Medical Virology 2020;92:556-63.
Chen J, Hu C, Chen L, Tang L, Zhu Y, Xu X et al. Clinical Study of Mesenchymal Stem Cell Treatment for Acute Respiratory Distress Syndrome Induced by Epidemic Influenza A (H7N9) Infection: A Hint for COVID-19 Treatment. Engineering 2020;6:1153-61.
Ali I, Alharbi O. COVID-19: Disease, management, treatment, and social impact. Science of The Total Environment. 2020;728:138861..
Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discoveries & Therapeutics. 2020;14(1):58-60.
Favalli E, Biggioggero M, Maioli G, Caporali R. Baricitinib for COVID-19: a suitable treatment?. The Lancet Infectious Diseases. 2020;20(9):1012-1013.
Colson P, Rolain J, Lagier J, Brouqui P, Raoult D. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. International Journal of Antimicrobial Agents. 2020;55(4):105932.
Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. Journal of Critical Care. 2020;57:279-283.
Cao Y. Suggestion Using Alcohol Vaporization or Nebulization Inhalation Therapy for Pneumonitis Caused by Coronavirus. SSRN Electronic Journal. 2020;.
Ago H, Adachi T, Yoshida A, Yamamoto M, Habuka N, Yatsunami K et al. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure. 1999;7(11):1417-1426.
Kouznetsova V, Zhang A, Tatineni M, Miller M, Tsigelny I. Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs. PeerJ. 2020;8:e9965.
Iyer M, Jayaramayya K, Subramaniam M, Lee S, Dayem A, Cho S et al. COVID-19: an update on diagnostic and therapeutic approaches. BMB Reports. 2020;53(4):191-205.
Boopathi S, Poma A, Kolandaivel P. Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment. Journal of Biomolecular Structure and Dynamics. 2020;:1-10.
Zhai P, Ding Y, Wu X, Long J, Zhong Y, Li Y. The epidemiology, diagnosis and treatment of COVID-19. International Journal of Antimicrobial Agents. 2020;55(5):105955.
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