APPLYING NANOPARTICLES FOR TREATING GIARDIA INFECTION: A SYSTEMATIC REVIEW
Keywords:Giardia lamblia, Giardia intestinalis, Giardia duodenalis, Nanoparticles, Tau Aggregation Inhibitors, In vitro, Clinical trial
At present, chemotherapy with some drugs such as nitroimidazoes derivatives is the preferred treatment for giardiasis. However, these agents are associated with adverse side effects ranging from nausea to possible genotoxicity. The present investigation was designed to systematically review the in vitro, in vivo, and clinical studies about the efficacy of nanoparticles against giardiasis. The study was carried out based on the 06-PRISMA guideline and registered in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-analysis Facility (SyRF) database. The search was performed in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar, without time limitation for publications around the world about anti-Giardia effects of all organic and inorganic nanoparticles without date limitation in order to identify all the published articles. The searched words and terms were “Giardiasis”, “Giardia lamblia”, “Giardia intestinalis”, “Giardia duodenalis”, “nanoparticles”, “nanomedicine”, “in vitro”, in vivo”, and “clinical trial”. Out of 312 papers, 10 papers, including 4 in vitro (40.0%), 5 in vivo (50.0%), and 1 in vitro/in vivo (10.0%) up to 2021 met the inclusion criteria for discussion in this systematic review. The most common type of nanoparticles was metal nanoparticles (5 studies, 50.0%) such as silver, gold, etc., followed by organic nanoparticles such as chitosan nanoparticles (4 studies, 40.0%). The results of this review study showed the high efficacy of a wide range of organic and non-organic NPs against giardiasis, indicating that nanoparticles could be considered as an alternative and complementary resource for treating giardiasis, since they have no significant toxicity. However, more studies are required to elucidate this conclusion, especially in clinical systems.
Lujan HD. Giardia and giardiasis. Medicina (B Aires) 2006;66:70-4.
Adam RD. Biology of giardia lamblia. Clin Microbiol Rev 2001;14:447-75.
Obulesu G, Ar H. A study of stool samples from hiv positive and hiv negative at Andhra Pradesh. Asian J Pharm Clin Res 2018;1:394-7.
Hooshyar H, Rostamkhani P, Arbabi M, Delavari M. Giardia lamblia infection: review of current diagnostic strategies. Gastroenterol Hepatol Bed Bench 2019;12:3-12.
Escobedo AA, Cimerman S. Giardiasis: a pharmacotherapy review. Expert Opin Pharmacother 2007;8:1885-902.
Tian HF, Chen B, Wen JF. Giardiasis, drug resistance, and new target discovery. Infect Disord Drug Targets 2010;10:295-302.
Lalle M, Hanevik K. Treatment-refractory giardiasis: challenges and solutions. Infect Drug Resist 2018;11:1921-33.
Kingsley JD, Dou H, Morehead J, Rabinow B, Gendelman HE, Destache CJ. Nanotechnology: a focus on nanoparticles as a drug delivery system. J Neuroimmune Pharmacol 2006;1:340-50.
Nafari A, Cheraghipour K, Sepahvand M, Shahrokhi G, Gabal E, Mahmoudvand H. Nanoparticles: new agents toward treatment of leishmaniasis. Parasite Epidemiol Control 2020;10:e00156.
Albalawi AE, Alanazi AD, Baharvand P, Sepahvand M, Mahmoudvand H. High potency of organic and inorganic nanoparticles to treat cystic echinococcosis: an evidence-based review. Nanomaterials 2020;10:2538.
Albalawi AE, Khalaf AK, Alyousif MS, Alanazi AD, Baharvand P, Shakibaie M, et al. Fe3O4@ piroctone olamine magnetic nanoparticles: synthesize and therapeutic potential in cutaneous leishmaniasis. Biomed Pharmacother 2021;139:111566.
Moher D, Liberati A, Tetzlaff J, Altman DG, Prisma Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151:264–9.
Yarahmadi M, Fakhar M, Ebrahimzadeh MA, Chabra A, Rahimi-esboei B. The anti-giardial effectiveness of fungal and commercial chitosan against Giardia intestinalis cysts in vitro. J Parasit Dis 2016;40:75–80.
Chabra A, Rahimi Esboei B, Habibi E, Monadi T, Azadbakht M, Elmi T, et al. Effects of some natural products from fungal and herbal sources on Giardia lamblia in vivo. Parasitology 2019;146:1188–98.
El-Gendy AM, Mohammed MA, Ghallab MM, Abdel Aziz MO, Ibrahim SM. Therapeutic effect of chitosan nanoparticles and metronidazole in the treatment of experimentally giardiasis infected hamsters. Iranian J Parasitol 2021;16:32-42.
Said DE, ElSamad LM, Gohar YM. Validity of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents. Parasitol Res 2012;111:545–54.
Bavand Z, Gholami S, Honari S, Rahimi Esboei B, Torabi N, Borabadi H. Effect of gold nanoparticles on Giardia Lamblia cyst stage in in vitro. Arak Med Univ J 2014;16:27–37.
Al-Ardi MH. The uses of gold nanoparticles and Citrullus colocynthis L. nanoparticles against Giardia lamblia in vivo. Clin Epidemiol Glob Heal 2020;8:1282-6.
Elmi T, Rahimi Esboei B, Sadeghi F, Zamani Z, Didehdar M, Fakhar M, et al. In vitro antiprotozoal effects of nano-chitosan on Plasmodium falciparum, Giardia lamblia and Trichomonas vaginalis. Acta Parasitol 2021;66:39-52.
Malekifard F, Tavassoli KV M. In vitro assessment antiparasitic effect of selenium and copper nanoparticles on giardia deodenalis cyst. Iran Soc Parasitol 2020;15:411-7.
Idan EM, Ardalan NM. Introducing silver nanoparticles as anti-giardial in experimentally infected mice. Ther Versus Toxicity 2020;11:701–8.
Reham M Brakat, Shaimaa A Sharaf EL-Deen HIAE. Zinc oxide nanoparticles kill giardia and protect against intestinal damage. Egypt J Med Microbiol 2019;28:95-103.
AlMohammed HI, Khudair Khalaf A, E Albalawi A, Alanazi AD, Baharvand P, Moghaddam A, et al. Chitosan-based nanomaterials as valuable sources of anti-leishmanial agents: a systematic review. Nanomaterials 2021;11:689.
Patel DP, Singh S. Chitosan: a multifaceted polymer. Int J Curr Pharm Res 2015;7:21-8.
Muxika A, Etxabide A, Uranga J, Guerrero P, de la Caba K. Chitosan as a bioactive polymer: processing, properties and applications. Int J Biol Macromol 2017;105:1358–68.
Wang W, Meng Q, Li Q, Liu J, Zhou M, Jin Z, et al. Chitosan derivatives and their application in biomedicine. Int J Mol Sci 2020;21:487.
Ahmed TA, Aljaeid BM. Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery. Drug Des Dev Ther 2016;10:483–507.
Cheraghipour K, Masoori L, Ezzatkhah F, Salimikia I, Amiri S, Makenali AS, et al. Effect of chitosan on toxoplasma gondii infection: a systematic review. Parasite Epidemiol Control 2020;11:e00189.
Rize BR, Younes NN, Rasool K, Nasrallah GK. Synthesis, bioapplications, and toxicity evaluation of chitosan-based nanoparticles. Int J Mol Sci 2019;20:5776.
Guan G, Azad AK, Lin Y, Kim SW, Tian Y, Liu G, et al. Biological effects and applications of chitosan and chitooligosaccharides. Front Physiol 2019;10:516.
Rozman NAS, Tong WY, Leong CR, Tan WN, Hasanolbasori MA, Abdullah SZ. Potential antimicrobial applications of chitosan nanoparticles (ChNP). J Microbiol Biotechnol 2019;29:1009–13.
Krishnamurthy G, Roy D, Kumar J. Curcumin, a natural golden drug and its anticancer aspects from synthesis to delivery: a review. Int J Appl Pharm 2020;7:70-84.
Cheraghipour K, Ezatpour B, Masoori L, Marzban A, Sepahvand A, Rouzbahani AK, et al. Anti-candida activity of curcumin: a systematic review. Curr Drug Discovery Technol 2021;18:379-90.
Satyavani K, Gurudeeban S, Ramanathan T, Balasubramanian T. Biomedical potential of silver nanoparticles synthesized from calli cells of citrullus colocynthis (L.) schrad. J Nanobiotechnol 2011;9:43.
Hussain AI, Rathore HA, Sattar MZ, Chatha SA, Sarker SD, Gilani AH. Citrullus colocynthis (L.) schrad (bitter apple fruit): a review of its phytochemistry, pharmacology, traditional uses and nutritional potential. J Ethnopharmacol 2014;15:54-66.
Dykman LA, Khlebtsov NG. Gold nanoparticles in biology and medicine: recent advances and prospects. Acta Nat 2011;3:34–55.
Das M, Shim KH, An SSA, Yi DK. Review on gold nanoparticles and their applications. Toxicol Environ Health Sci 2011;3:193–205.
Zhang XF, Liu ZG, Shen W, Gurunathan S. Silver nanoparticles: Synthesis, characterization, properties, applications, and therapeutic approaches. Int J Mol Sci 2016;17:1534.
Rayman MP. Selenium and human health. Lancet 2012;379:1256-68.
Ezzatkhah F, Khalaf AK, Mahmoudvand H. Copper nanoparticles: biosynthesis, characterization, and protoscolicidal effects alone and combined with albendazole against hydatid cyst protoscoleces. Biomed Pharmacother 2021;136:111257.
Albalawi AE, Abdel Shafy S, Khudair Khalaf A, Alanazi AD, Baharvand P, Ebrahimi K, et al. Therapeutic potential of green synthesized copper nanoparticles alone or combined with meglumine antimoniate (glucantime®) in cutaneous leishmaniasis. Nanomaterials 2021;11:891.
Saadatmand M, Al-Awsi GR, Alanazi AD, Sepahvand A, Shakibaei M, Shojaee S, et al. Green synthesis of zinc nanoparticles using lavandula angustifolia vera. extract by microwave method and its prophylactic effects on Toxoplasma gondii infection. Saudi J Biol Sci 2021. https://doi.org/10.1016/j.sjbs.2021.07.007
Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: an integrative review. J Res Med Sci 2013;18:144.
Sirelkhatim A, Mahmud S, Seeni A, Kaus NH, Ann LC, Bakhori SK, et al. Review on zinc oxide nanoparticles: antibacterial activity and toxicity mechanism. Nano-micro Lett 2015;7:219-42.
Nadhman A, Nazir S, Khan MI, Ayub A, Muhammad B, Khan M, et al. Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans. Int J Nanomed 2015;10:6891-903.
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Copyright (c) 2021 HAMDAN I. ALMOHAMMED, AISHAH E. ALBALAWI, HADEEL AL SADOUN, NAVID BAKHTIARI, MORTEZA AMRAEI, ALI MOGHADDAM, GHAIDAA RAHEEM LATEEF AL-AWSI
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