IMPACT OF COVID-19 ON MULTIPLE BODY ORGAN FAILURE: A REVIEW

Authors

  • AYA YASEEN MAHMOOD ALABDALI Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur (South Wing), No. 1, Jalan Menara Gading, UCSI Heights 56000 Cheras, Kuala Lumpur, Malaysia
  • SASIKALA CHINNAPPAN Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur (South Wing), No. 1, Jalan Menara Gading, UCSI Heights 56000 Cheras, Kuala Lumpur, Malaysia
  • BASMA M. ABD RAZIK Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, 10001, Baghdad, Iraq
  • MOGANA R. Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur (South Wing), No. 1, Jalan Menara Gading, UCSI Heights 56000 Cheras, Kuala Lumpur, Malaysia
  • SHAIK IBRAHIM KHALIVULLA Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur (South Wing), No. 1, Jalan Menara Gading, UCSI Heights 56000 Cheras, Kuala Lumpur, Malaysia
  • RAHMAN H. Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur (South Wing), No. 1, Jalan Menara Gading, UCSI Heights 56000 Cheras, Kuala Lumpur, Malaysia
  • LAITH H. SAMEIN The University of Mashreq, College of Pharmacy, Baghdad, Iraq

DOI:

https://doi.org/10.22159/ijap.2021v13i5.42653

Keywords:

Corona virus disease (COVID-19), Organ failure, SAR-CoV-2, Cardiovascular system, Kidney, Lungs

Abstract

COVID-19 is a highly contagious disease caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2); which is a novel single-stranded positive RNA infection which consist of cytokines that activate the pathogenic systems that cause high respiratory pain condition, and adversely affect on multiple body organ in humans as per their immunity standards to fight against the virus. SARS-CoV-2 enters the host cell through Angiotensin-Converting Enzyme 2 (ACE 2). ACE 2 is a sub-part of the Renin-Aldosterone Angiotensin System (RAAS), intelligently communicated in the body's kidney, heart, lungs, and malignant tissues. The malfunctioning of RAAS in the body leads to hypertension, cardiovascular sicknesses, endocrine system and negatively affects a brain-body communication channel. Treatments on the RAAS structure, 'thiazolidinedione's and smoking, toxemia, kidney, lungs disorder due to the SARS-CoV-2 attack on the host cell and notice the behavioral changes of body organs the arrival of cytokines that causes multi-organ damage. This paper involves the study of the effects of coronavirus disease on multiple body-organ injuries.

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Published

07-09-2021

How to Cite

MAHMOOD ALABDALI, A. Y., CHINNAPPAN, S., ABD RAZIK, B. M., R., M., KHALIVULLA, S. I., H., R., & SAMEIN, L. H. (2021). IMPACT OF COVID-19 ON MULTIPLE BODY ORGAN FAILURE: A REVIEW. International Journal of Applied Pharmaceutics, 13(5), 54–59. https://doi.org/10.22159/ijap.2021v13i5.42653

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Section

Review Article(s)