STATISTICAL OPTIMIZATION AND EVALUATION OF ETHOSOMAL MICONAZOLE NITRATE SUSPENSION

Authors

  • N. MADHURI Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam 530049
  • N. TEJASWINI Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam 530049
  • MEENAL PATEL Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam 530049
  • P. JYOTHI Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam 530049
  • K. JYOTHSNA Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam 530049
  • P. N. MALLIKARJUN Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam 530049

DOI:

https://doi.org/10.22159/ijap.2022v14i1.43048

Keywords:

Ethosomes, Miconazole, Ethanol, Isopropyl alcohol, Antifungal, Cold method,Optimization.

Abstract

Objective: The objectives of the present study were to optimize and evaluate the ethosomal suspension of miconazole nitrate for the treatment of local and systemic fungal infections.

Methods: Miconazole topical formulation is prepared for better patient compliance and to reduce the dose of a drug. Miconazole nitrate ethosomes were prepared by the cold method using factorial designing with Ethanol(X1), IPA(Isopropyl alcohol)(X2), and Lecithin(X3) as Independent variables and % EE(Entrapment efficiency)(Y1) and % DR(drug release at 8th h)(Y2)  was selected as responses.

Results: The results obtained in the design showed that there was no significant interaction among factors. The lecithin concentration had a positive response on % EE while ethanol concentration and IPA had a positive effect. For %  DR, Ethanol, and IPA showed a positive effect and Lecithin had a negative response. The formulation EM22 (3 ml X1,3 ml X2 and 300mg of X3)  characterized  by  high  % EE(77.3 %) and optimum % DR(94.2%) and formulation EM6 (2 ml X1,2 ml X2 and 100 mg of X3 )  characterized  by  high  % DR(97.32 %)  and optimum % EE (74.8 %).EM22 was incorporated in the gel as it is showing more entrapment efficiency and compared with the marketed product for drug release.

 Conclusion: From the result, it was concluded that formulated ethosomal suspension and optimized gel have more drug release than marketed formulation so that formulated suspension can be used for the preparation of antifungal gels, creams, ointments for sustained release.

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Published

02-11-2021

How to Cite

MADHURI, N., TEJASWINI, N., PATEL, M., JYOTHI, P., JYOTHSNA, K., & MALLIKARJUN, P. N. (2021). STATISTICAL OPTIMIZATION AND EVALUATION OF ETHOSOMAL MICONAZOLE NITRATE SUSPENSION. International Journal of Applied Pharmaceutics, 14(1). https://doi.org/10.22159/ijap.2022v14i1.43048

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