DESIGN AND EVALUATION OF FAST DISSOLVING GRANULES OF SALBUTAMOL SULFATE

Authors

  • JINAN M. AL-MOUSAWY Collage of Pharmacy /University of Kerbala, Kerbala, Iraq https://orcid.org/0000-0001-6372-8005
  • JAMAL A. ASHOOR Collage of Pharmacy /University of Kerbala, Kerbala, Iraq
  • MUQDAM M. MOHAMMED ALI Collage of Pharmacy /University of Kerbala, Kerbala, Iraq

DOI:

https://doi.org/10.22159/ijap.2022v14i2.43206

Keywords:

granules, banana powder, fast.

Abstract

Objective: Appropriateness of administration and patient complaints are important factors in developing dosage forms especially for children and elderly people. The goal of this research was to develop salbutamol sulfate granules that dissolve quickly to improve patient compliance.

Methods: Five formulas (F1-F5) were prepared by wet granulation methods.

Different type of excipients was used in the formulation like banana powder as super disinterring, mannitol, hydroxyl propyl methylcellulose; etc. The formulas were evaluated for flow properties, drug compatibility study by FTIR, drug content, and drug release profile.

Results:  The result revealed that the flowability of the five formulas has accepted flow properties; The FTIR studies of the formula F2 showed no drug-excipients interaction.  All of the prepared formulas show an acceptable range of drug content, a rapid release of drug of about 95.2% within 10 min. These results indicate good and rapid release properties of salbutamol sulfate from fast dissolving granules.

Conclusion: Salbutamol sulfate was successfully formulated as fast- dissolving granules by using banana powder.

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References

R. Pahwa, M. Piplani, P. C. Sharma, D. Kaushik, and S. Nanda, “Orally disintegrating tablets—friendly to pediatrics and geriatrics,” Arch. Appl. Sci. Res.2010; 2: (2) 35–48.

S. Divate, K. Kavitha, and G. N. Sockan, “Fast disintegrating tablets—an emerging trend,” Int. J. Pharm. Sci. Rev. Res.2011; 6( 2): 18–22, 2011.

Bhusan SY, Sambhaji SP, Anant RP, Kakasaheb RM. New drug delivery system for elderly. Indian Drugs.2000; 37: 312-318.

Wadhwani AR, Prabhu NB, Nandkarni MA, Amin. Consumer friendly mucolytic formulations. Indian J Pharm Sci .2004; 7: 506-507.

M. Swamivelmanickam, R. Manavalan, and K. Valliappan. Mouth dissolving tablets: an overview. Int. J. Pharm. Sci. Res. 2010; 1:12, 43–55.

K. D. Tripathi. Essential of Medical Pharmacology,216–217, Jaypee Brothers Medical, New Delhi, India, 6th edition, 2008.

Dilip M. Parikh. Handbook of Pharmaceutical Granulation Technology. third edition.2009; 183

Deepak Sharma. Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders. ISRN Pharma. 2013; 2013, 8

Sanjay S. Patel, Natvarlal M. Patel. Development of Directly Compressible Co-Processed Excipients for Dispersible Tablets Using 32 Full Factorial Designs. Int. J. Pharm. Pharm. Sci. 2009; 1(1): 125-148.

Senthil, P. Suresh Kumar, CH. Narasimha Raju, S. Mohideen. Formulation and evaluation of gastric oral floating tablet of glipizide. IJBPR. 2010; 1(2): 108-113.

Dhahir, R. K.,Al-kotaji, M. Formulation of orally disintegrant tablets of cinnarizine by using direct compression method. Int J App Pharm. 2019; 11(1), 117–123.

Kotaro II., Youhei HA, Hirokazu OK., Kazumi Danjo Hans. Evaluation of Flow Properties of Dry Powder Inhalation of Salbutamol Sulfate with Lactose Carrier. Chem. Pharm. Bull.2001; 49(10) 1326—1330.

Kaerger S, Edge S, Price R. Influence of particle size and shape on flowability and compatibility of binary mixtures of paracetamol and microcrystalline cellulose. Eur J Pharm Sci .2004; 22:173-9.

Paulo C., Jose M.S..Modeling and comparison of dissolution profiles. Eur. J Pharm. Sci. 2001; 13: 123-133.

Meenakshi Bh. , Santosh Kit. , Kalpesh Ga. Formulation and Characterization of Fast Dissolving Tablet of Salbutamol Sulphate. Am. J. Pharmacol.Sci. 2018; 6(1): 1-6

Sarasja su.,V. Pandit ,H. P. Joshi. Preparation and evaluation of mouth dissolving tablets of salbutamol sulphate. Indian J Pharm Sci. 2007; 467-469.

Silverstein, spectrometric identification of organic compounds, 2015, 7th edition.

British Pharmacopoeia. 2009.

Seager H. Drug delivery products and Zydis fast dissolving dosage form. J Pharmacol Pharm .1998; 50:375–382.

Olufunke C. Babalola1, Oluwatoyin A. Odeku. Disintegrant properties of banana starch obtained from the unripe fruits of Musa sapientum. J. Appl. Pharm. Sci. 2014; 4 (09), 083-088.

R. B. Saudagar. Formulation characterization and evaluation of mouth dissolving tablet of lisinopril by using dehydrated banana powder.WJIPR.2015; 4, 12, 763-774.

Md Tausif Alam, Nayyar Parvez, and Pramod Kumar Sharma, FDA-Approved Natural Polymers for Fast Dissolving Tablets. J. Pharm.2014; 2, 1- 6.

Prabakaranl, Sendhil D. Formulation development of patient friendly dosage from: All in one natural excipients as binder, diluents and disintegrant. Int. J. Pharm. Pharm. Sci.2011; 3(2), 97¬-102.

Ashoor JA, Rajab NA, Ghareeb MM, Abdulrasool AA. Preparation and evaluation of orodispersible tablets of finasteride using co-processed excipients. Int J Pharmacy Pharm Sci. 2013; 5(2):64-9.

Published

15-12-2021

How to Cite

AL-MOUSAWY, J. M., ASHOOR, J. A., & MOHAMMED ALI, M. M. (2021). DESIGN AND EVALUATION OF FAST DISSOLVING GRANULES OF SALBUTAMOL SULFATE. International Journal of Applied Pharmaceutics, 14(2). https://doi.org/10.22159/ijap.2022v14i2.43206

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