DIACEREIN- LOADED NIOSOMES (DC-NS): A NEW TECHNIQUE TO SUSTAIN THE RELEASE OF DRUG ACTION

Authors

  • RASHAD M. KAOUD Pharmacy Department, Ashur University College, PO Box 10047, Baghdad, Iraq https://orcid.org/0000-0001-8537-7066
  • EMAN J. HEIKAL Faculty of Pharmacy, the University of Mashreq, Baghdad, Iraq
  • TAHA M. HAMMADY Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

DOI:

https://doi.org/10.22159/ijap.2022v14i1.43353

Keywords:

Diacerein, Niosome, Cholesterol, Tween, Stearylamine and Stability

Abstract

Objective: The study's main goal is to develop a suitable niosomes (NS) encapsulated drug for anti-inflammatory effects such as diacerein (DC) and to evaluate the system's vesicle size (VS), entrapment efficiency (EE %), physical stability and in-vitro release.

Methods: Tween (40&60), cholesterol, and stearylamine were used in a 1:1:0.1 molar ratios as non-ionic surfactants. Thin film hydration was used to create the NS.

Results: The higher EE% was observed with NS (F11) prepared from tween 60, cholesterol and 2.5 min sonication. These formulations' release patterns were Higuchi diffusion & first order. For the stability study, NS formulations were stored at temperature between 2-8oC for 60 d retains the most drugs when compared to room and high temperature conditions.

Conclusion: The findings of this study have conclusively shown that after NS encapsulation of DC, drug release is prolonged at a constant and controlled rate.

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Published

22-11-2021

How to Cite

KAOUD, R. M., HEIKAL, E. J., & HAMMADY, T. M. (2021). DIACEREIN- LOADED NIOSOMES (DC-NS): A NEW TECHNIQUE TO SUSTAIN THE RELEASE OF DRUG ACTION. International Journal of Applied Pharmaceutics, 14(1). https://doi.org/10.22159/ijap.2022v14i1.43353

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Original Article(s)